(E)-3-(4-hydroxy-3-methoxyphenyl)-1-[4-(3,4,5-trimethoxybenzoyl)piperazino]-2-propen-1-one | 1226909-06-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-3-(4-hydroxy-3-methoxyphenyl)-1-[4-(3,4,5-trimethoxybenzoyl)piperazino]-2-propen-1-one
• 英文别名: (E)-3-(4-hydroxy-3-methoxyphenyl)-1-[4-(3,4,5-trimethoxybenzoyl)piperazin-1-yl]prop-2-en-1-one
• CAS: 1226909-06-3
• 化学式: C₂₄H₂₈N₂O₇
• 分子量: 456.496
• InChiKey: BEEDMWWOHMOXBM-SOFGYWHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  97.8
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (E)-3-(4-hydroxy-3-methoxyphenyl)-1-[4-(3,4,5-trimethoxybenzoyl)piperazino]-2-propen-1-one 、 (2S)-N-[4-(5-bromopentyloxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以78%的产率得到(2S)-N-{4-[5-[2-methoxy-4-((E)-3-oxo-3-[4-(3,4,5-trimethoxybenzoyl)piperazino]-1-propenyl)phenoxy]pentoxy]-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl dithioacetal
  参考文献：
  名称：

  Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents

  摘要：

  A series of new cinnamido-pyrrolo[2,1-c][1,4)benzodiazepine conjugates (4a-d and 5a-d) and their dimers (6a-d) have been designed, synthesized and evaluated for their biological activity. The anticancer screening of compound 4a by the NCI exhibited significant GI50 values ranging from 68 to 732 nM against 53 of 59 human cancer cell lines tested. Compounds 5a-d and 6a-d have also shown remarkable cytotoxic activity with GI50 values <0.1 mu M concentrations in a large number of cell lines. Interestingly, compounds 5b and 6b have been identified as a new class of inhibitors of tubulin polymerization and their action has been rationalized by the cell cycle arrest in GO and G2/M phase. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.05.041
• 作为产物：
  描述：

  ferulic acid chloride 、 1-(3,4,5-trimethoxybenzoyl)piperazine 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以84%的产率得到(E)-3-(4-hydroxy-3-methoxyphenyl)-1-[4-(3,4,5-trimethoxybenzoyl)piperazino]-2-propen-1-one
  参考文献：
  名称：

  Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents

  摘要：

  A series of new cinnamido-pyrrolo[2,1-c][1,4)benzodiazepine conjugates (4a-d and 5a-d) and their dimers (6a-d) have been designed, synthesized and evaluated for their biological activity. The anticancer screening of compound 4a by the NCI exhibited significant GI50 values ranging from 68 to 732 nM against 53 of 59 human cancer cell lines tested. Compounds 5a-d and 6a-d have also shown remarkable cytotoxic activity with GI50 values <0.1 mu M concentrations in a large number of cell lines. Interestingly, compounds 5b and 6b have been identified as a new class of inhibitors of tubulin polymerization and their action has been rationalized by the cell cycle arrest in GO and G2/M phase. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.05.041

文献信息

• [EN] CINNAMIDO-PVRROLOR[2,1-C][1,4]BENZODIAZEPINES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF<br/>[FR] CINNAMIDO-PVRROLOR[2,1-C][1,4]BENZODIAZÉPINES UTILIÉES COMME AGENTS ANTICANCÉREUX POTENTIELS ET PROCESSUS DE PRÉPARATION DE CES COMPOSÉS
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2010052732A1

  公开（公告）日：2010-05-14

  The present invention provides a compound of general formulae (8a-i), (11a-i), (14a-i), and (17a-i), useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of Cinnamido-pyrrolo[2,1-c][1,4]benzodiazepines of general formulae (8a-i), (11a-i), (14a-i), and (17a-i).

  本发明提供了一种通用公式（8a-i）、（11a-i）、（14a-i）和（17a-i）的化合物，可作为潜在的抗人类癌细胞系肿瘤药物。本发明还提供了一种制备通用公式（8a-i）、（11a-i）、（14a-i）和（17a-i）的桂皮基吡咯并[2,1-c][1,4]苯二氮杂环丙烷的方法。
• CINNAMIDO-PYRROLO[2,1-C][1,4]BENZODIAZEPINES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF
  申请人：Ahmed Kamal

  公开号：US20120095213A1

  公开（公告）日：2012-04-19

  The present invention provides a compound of general formulae (8a-i), (11a-i), (14a-i), and (17a-i), useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of Cinnamido-pyrrolo[2,1-c][1,4]benzodiazepines of general formulae (8a-i), (11a-i), (14a-i), and (17a-i).
• US8722665B2
  申请人：——

  公开号：US8722665B2

  公开（公告）日：2014-05-13
• Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents
  作者：Ahmed Kamal、G. Balakishan、G. Ramakrishna、T. Basha Shaik、K. Sreekanth、M. Balakrishna、Rajender、D. Dastagiri、Shasi V. Kalivendi

  DOI：10.1016/j.ejmech.2010.05.041

  日期：2010.9

  A series of new cinnamido-pyrrolo[2,1-c][1,4)benzodiazepine conjugates (4a-d and 5a-d) and their dimers (6a-d) have been designed, synthesized and evaluated for their biological activity. The anticancer screening of compound 4a by the NCI exhibited significant GI50 values ranging from 68 to 732 nM against 53 of 59 human cancer cell lines tested. Compounds 5a-d and 6a-d have also shown remarkable cytotoxic activity with GI50 values <0.1 mu M concentrations in a large number of cell lines. Interestingly, compounds 5b and 6b have been identified as a new class of inhibitors of tubulin polymerization and their action has been rationalized by the cell cycle arrest in GO and G2/M phase. (C) 2010 Elsevier Masson SAS. All rights reserved.