6,7-二氯喹啉 | 40635-11-8

• 物质功能分类: 医药中间体 - 杂环化合物 - 喹啉类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 6,7-二氯喹啉
• 英文名称: 6,7-dichloroquinoline
• 英文别名: 6.7-Dichlor-chinolin
• CAS: 40635-11-8
• 化学式: C₉H₅Cl₂N
• mdl: MFCD09878431
• 分子量: 198.051
• InChiKey: VOEBOQZMOGFLTJ-UHFFFAOYSA-N

物化性质

• 熔点：
  131.6-131.9 °C
• 沸点：
  311.1±22.0 °C(Predicted)
• 密度：
  1.407±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 6,7-Dichloroquinoline
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 6,7-Dichloroquinoline
CAS number: 40635-11-8

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C9H5Cl2N
Molecular weight: 198.0

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4，5-二甲基-1，2-苯二胺 、 6,7-二氯喹啉 生成
  参考文献：
  名称：

  一种p型有机正极材料及其制备方法和应用

  摘要：

  本发明涉及一种有机正极材料，具体涉及一种p型有机正极材料及其制备方法和应用，所述的材料为二氢‑5,6,11,12‑四氮杂并四苯，结构式如下式(I)所示：#imgabs0#与现有技术相比，本发明解决现有技术中p型有机物容量较低的问题；本发明提出了一种具有活性位点的高电压p型有机正极材料。

  公开号：

  CN117820318A
• 作为产物：
  描述：

  甲磺酰胺,N-(3,4-二氯苯基)- 在 三氟甲磺酸 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 0.17h， 生成 6,7-二氯喹啉
  参考文献：
  名称：

  Tokuyama, Hidetoshi; Sato, Masashi; Ueda, Toshihiro, Heterocycles, 2001, vol. 54, # 1, p. 105 - 108

  摘要：

  DOI：

文献信息

• [EN] COMPOSITIONS FOR THE TREATMENT OF BRAIN TUMORS<br/>[FR] COMPOSITIONS DESTINÉES AU TRAITEMENT DE TUMEURS CÉRÉBRALES
  申请人：INNOCRIN PHARMACEUTICALS INC

  公开号：WO2019182743A1

  公开（公告）日：2019-09-26

  The instant invention describes pharmaceutical compositions and dosing regimens comprising seviteronel and/or dexamethasone, and methods of treating diseases, disorders symptoms thereof.

  这项即时发明描述了包含赛维特龙和/或地塞米松的药物组合物和给药方案，以及治疗疾病、疾病症状的方法。
• [EN] COMPOSITIONS FOR THE TREATMENT OF BRAIN TUMORS<br/>[FR] COMPOSITIONS POUR LE TRAITEMENT DE TUMEURS CÉRÉBRALES
  申请人：INNOCRIN PHARMACEUTICALS INC

  公开号：WO2020077197A1

  公开（公告）日：2020-04-16

  The instant invention describes pharmaceutical compositions and dosing regimens comprising radiation therapy and seviteronel with or without dexamethasone, and methods of treating diseases, disorders or symptoms thereof.

  这项即时发明描述了包括放射治疗和赛维特鲁内尔在内或不包括地塞米松的药物组合物和给药方案，以及治疗疾病、疾病或症状的方法。
• METALLOENZYME INHIBITOR COMPOUNDS
  申请人：Innocrin Pharmaceuticals, Inc.

  公开号：US20170143694A1

  公开（公告）日：2017-05-25

  The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.

  本发明描述了具有金属酶调节活性的化合物，以及治疗由这些金属酶介导的疾病、疾病或症状的方法。
• NOVEL NEUROTRYPSIN INHIBITORS
  申请人：Ahmed Shaheen

  公开号：US20130245064A1

  公开（公告）日：2013-09-19

  The invention relates to novel acylamino-hydroxy-benzamides of formula (I), wherein R 1 is phenyl substituted by phenyl, phenoxy, phenylamino or heteroaryl, all optionally further substituted; bicyclic aryl, monocyclic heteroaryl substituted by optionally substituted phenyl, or bicyclic heteroaryl, R 2 is hydrogen or methyl, and R 3 and R 4 have the meanings indicated in the description. These compounds are useful for the treatment and/or prophylaxis of skeletal muscle atrophy, schizophrenia and Alzheimer's disease, and as cognitive enhancers.

  本发明涉及一种新型的酰基氨基-羟基苯甲酰胺化合物，其化学式为（I），其中R1为苯基，其上取代基为苯基、苯氧基、苯胺基或杂环基，均可进一步取代；双环芳基、单环杂环基，其上取代基为可选择取代的苯基，或双环杂环基；R2为氢或甲基，R3和R4的含义如说明书所示。这些化合物可用于治疗和/或预防骨骼肌萎缩、精神分裂症和阿尔茨海默病，并作为认知增强剂。
• NOVEL IMIDAZOLE QUINOLINE-BASED IMMUNE SYSTEM MODULATORS
  申请人：JANUS BIOTHERAPEUTICS, INC.

  公开号：US20140242121A1

  公开（公告）日：2014-08-28

  The present invention relates to a compound of Formula I: or an enantiomer, diastereomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.

  本发明涉及化合物I式：或其对映异构体、顺反异构体、互变异构体、药学上可接受的盐或溶剂，其中符号如规范中所定义; 包括该化合物的药物组合物;以及使用该化合物治疗或预防自身免疫疾病的方法。