花翠素3,5二糖苷 | 17670-06-3

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 花翠素3,5二糖苷
• 中文别名: 氯化花翠素-3,5-二葡糖苷；飞燕草素3,5-葡萄糖苷
• 英文名称: delphinidin-3,5-O-β-diglucopyranoside
• 英文别名: delphinidin 3-O-glucoside-5-O-glucoside；delphinidin 3,5-O-diglucoside；Delphin chloride；3,5-bis-β-D-glucopyranosyloxy-7-hydroxy-2-(3,4,5-trihydroxy-phenyl)-chromenylium; chloride；3,5-Bis-β-D-glucopyranosyloxy-7-hydroxy-2-(3,4,5-trihydroxy-phenyl)-chromenylium; Chlorid；delphinidin 3,5 diglucoside；Delphinidin-3,5-O-diglucoside chloride；(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[7-hydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-(3,4,5-trihydroxyphenyl)chromenylium-5-yl]oxyoxane-3,4,5-triol;chloride
• CAS: 17670-06-3
• 化学式: C₂₇H₃₁O₁₇*Cl
• 分子量: 662.986
• InChiKey: HKHQPWJHAKAMGC-LYQFWTOWSA-N

物化性质

• 溶解度：
  溶于甲烷

计算性质

• 辛醇/水分配系数(LogP)：
  -5.44
• 重原子数：
  45
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  281
• 氢给体数：
  12
• 氢受体数：
  17

安全信息

• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  2,4-dihydroxy-6-(tetra-O-acetyl-β-D-glucopyranosyloxy)-benzaldehyde 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙酸乙酯 作用下， 生成 花翠素3,5二糖苷
  参考文献：
  名称：

  Reynolds et al., Journal of the Chemical Society, 1934, p. 1235,1237

  摘要：

  DOI：

文献信息

• [EN] HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME<br/>[FR] COMPOSÉS HÉTÉROARYLE UTILES EN TANT QU'INHIBITEURS DE L'ENZYME D'ACTIVATION SUMO
  申请人：DUFFEY MATTHEW O

  公开号：WO2016004136A1

  公开（公告）日：2016-01-07

  Disclosed are chemical entities which are compounds of formula (I); or pharmaceutically acceptable salts thereof; wherein Y, Ra, Ra', Rb, Rc, X1, X2, X3, Rd, Z1, and Z2 have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.

  公开了公式(I)的化合物或其药物可接受的盐； 其中Y、Ra、Ra'、Rb、Rc、X1、X2、X3、Rd、Z1和Z2具有本文所述的值，并且星号位置表示的立体化学配置指示绝对立体化学。 根据本公开的化学实体可用作Sumo激活酶（SAE）的抑制剂。 进一步提供了包含本公开化合物的药物组合物以及使用该组合物治疗增殖性、炎症性、心血管和神经退行性疾病或病症的方法。
• [EN] COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF AS INHIBITORS OF RAN GTPASE<br/>[FR] COMPOSÉS, COMPOSITIONS PHARMACEUTIQUES ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE LA RAN GTPASE
  申请人：THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV

  公开号：WO2019046931A1

  公开（公告）日：2019-03-14

  Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions involving Ran GTPase.

  以下概述了通式IA、IB和IC的化合物，包括其药用盐、溶剂合物和水合物。这些化合物和包含它们的药物组合物可用于涉及Ran GTP酶的医疗状况。
• [EN] COMPOUNDS USEFUL FOR THE TREATMENT AND/OR CARE OF THE SKIN, HAIR, NAILS AND/OR MUCOUS MEMBRANES<br/>[FR] COMPOSÉS UTILES DANS LE TRAITEMENT ET/OU LES SOINS DE LA PEAU, DES CHEVEUX, DES ONGLES ET/OU DES MUQUEUSES
  申请人：LUBRIZOL ADVANCED MAT INC

  公开号：WO2019008452A1

  公开（公告）日：2019-01-10

  A compound of formula (I) R1-Wm-Xn-AA1-AA2-AA3-AA4-AA5-AA6-AA7-AA8-AA9-Yp-Zq-R2 wherein AA1 is Phe; AA2 is Trp; AA3 is selected from the group consisting of Met, Leu and lie; AA4 is selected from the group consisting of Lys, Arg and Gin; AA5 is Arg; AA6 is Lys; AA7 is selected from the group consisting of Arg, Lys and His; AA8 is selected from the group consisting of Val, lie, Leu and Met; and AA9 is Pro, useful in the treatment and/or care of the skin, hair, nails and/or mucous membranes, in particular for improving the barrier function of the skin, for energising the skin and as an anti- aging agent.

  一种具有以下结构的化合物（I）R1-Wm-Xn-AA1-AA2-AA3-AA4-AA5-AA6-AA7-AA8-AA9-Yp-Zq-R2，其中AA1为Phe；AA2为Trp；AA3选自Met、Leu和Ile组成的群体；AA4选自Lys、Arg和Gln组成的群体；AA5为Arg；AA6为Lys；AA7选自Arg、Lys和His组成的群体；AA8选自Val、Ile、Leu和Met组成的群体；AA9为Pro。该化合物在治疗和/或护理皮肤、头发、指甲和/或粘膜方面具有用途，特别用于改善皮肤的屏障功能，激活皮肤并作为抗衰老剂。
• [EN] CHEMICAL ACTIVATORS OF NICOTINAMIDE MONONUCLEOTIDE ADENLYLY TRANSFERASE 2 (NMNAT2) AND USES THEREOF<br/>[FR] ACTIVATEURS CHIMIQUES DE MONONUCLÉOTIDE DE NICOTINAMIDE ADÉNYLYL TRANSFÉRASE 2 (NMNAT2) ET LEURS UTILISATIONS
  申请人：UNIV TSINGHUA

  公开号：WO2020107221A1

  公开（公告）日：2020-06-04

  The present application relates to novel semicarbazones and thiosemicarbazones, to processes for preparing them, to pharmaceutical preparations comprising them, to the use of the novel semicarbazones and thiosemicarbazones for treatment and/or prophylaxis of diseases and to the use thereof for production of a medicament for treatment and/or prophylaxis of diseases, especially of neurodegeneration and age-associated diseases or conditions associated with NAD loss. The present application also provides a method for high throughput screening of NMNAT2 activators.

  本申请涉及新型半胱氨酮和硫代半胱氨酮，以及制备它们的方法，包括含有它们的药物制剂，以及利用新型半胱氨酮和硫代半胱氨酮治疗和/或预防疾病的用途，以及用于生产治疗和/或预防疾病的药物的用途，特别是神经退行性疾病和与NAD损失相关的老年疾病或状况。本申请还提供了一种高通量筛选NMNAT2激活剂的方法。
• Peptide-based diblock and triblock dispersants and diblock polymers
  申请人：O'Brien P. John

  公开号：US20050054752A1

  公开（公告）日：2005-03-10

  Peptides have been identified that bind with high affinity to common ink pigments and to various print media, including paper and fabrics. These peptides were used to prepare diblock and triblock dispersants for coating applications, including ink jet printing, and diblock polymers for treating paper and fabrics. The diblock dispersants consist of a pigment-binding peptide coupled to a hydrophilic linker, a pigment-binding peptide coupled to a print medium-binding peptide or a print medium-binding peptide coupled to a hydrophobic linker. The diblock polymers consist of a print medium-binding peptide coupled to a hydrophilic linker or a benefit agent. The triblock dispersants consist of a pigment-binding peptide coupled to a hydrophilic linker, which is coupled to a print medium-binding peptide.

  已经确定了与常见墨水颜料和各种印刷介质（包括纸张和织物）高亲和力结合的肽。这些肽被用于制备二嵌段和三嵌段分散剂，用于涂层应用，包括喷墨打印，以及用于处理纸张和织物的二嵌段聚合物。二嵌段分散剂包括一个与颜料结合的肽偶联到亲水性连接物，一个与颜料结合的肽偶联到印刷介质结合的肽，或一个与印刷介质结合的肽偶联到疏水性连接物。二嵌段聚合物包括一个与印刷介质结合的肽偶联到亲水性连接物或一种有益剂。三嵌段分散剂包括一个与颜料结合的肽偶联到亲水性连接物，该连接物再与印刷介质结合的肽偶联。