1,2,4-Ethanylylidene-1H-cyclobuta[cd]pentalen-5-amine,octahydro-N-methyl-(9CI) | 93779-11-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1,2,4-Ethanylylidene-1H-cyclobuta[cd]pentalen-5-amine,octahydro-N-methyl-(9CI)
• 英文别名: N-methylpentacyclo[5.4.0.02,6.03,10.05,9]undecan-8-amine
• CAS: 93779-11-4；136375-87-6
• 化学式: C₁₂H₁₇N
• 分子量: 175.274
• InChiKey: SXLLHCCBQVMPMW-UHFFFAOYSA-N

物化性质

• 沸点：
  261.9±8.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  五环[5.4.0.02,6.03,10.05,9]十一烷-8-酮 在 sodium tetrahydroborate 作用下， 以 乙醇 、 水 为溶剂， 反应 17.0h， 生成 1,2,4-Ethanylylidene-1H-cyclobuta[cd]pentalen-5-amine,octahydro-N-methyl-(9CI)
  参考文献：
  名称：

  Pentacyclo[5.4.0.02,6.03,10.05,9]undecylamines. Synthesis and pharmacology

  摘要：

  The synthesis and biological activity of a series of pentacyclo[5.4.0.0(2,6).0(3.10).0(5.9)]undecyl-8-amino derivatives are described. The activity of the compounds to antagonize the reserpine induced catatonia (anticataleptic) and their ability to reduce the oxotremorine induced tremor and salivation were determined in order to evaluate their potential as anti-Parkinson agents. Promising anticataleptic and mild to weak anticholinergic activities were observed for these compounds. The influence of substituents is discussed.

  DOI：

  10.1016/0223-5234(91)90097-7

文献信息

• [EN] ORGANO-TRANSITION METAL COMPLEXES FOR THE TREATMENT OF VIRAL INFECTIONS<br/>[FR] COMPLEXES ORGANOMÉTALLIQUES DE TRANSITION POUR LE TRAITEMENT DES INFECTIONS VIRALES
  申请人：BUSATH DAVID D

  公开号：WO2015192037A1

  公开（公告）日：2015-12-17

  Organo-transition metal complexes possess anti-viral inhibitory activity against influenza A, including the S3 IN mutant. The organo-transition metal complexes include a transition metal and at least one ligand based on the structure of an M2 proton channel blocker. Compounds and pharmaceutical compositions are useful for treating viruses such as influenza A.

  有机过渡金属配合物具有抗流感病毒的抑制活性，包括S3 IN突变体。有机过渡金属配合物包括过渡金属和至少一种基于M2质子通道阻滞剂结构的配体。这些化合物和药物组合物对治疗流感病毒等病毒有用。
• ORGANO-TRANSITION METAL COMPLEXES FOR THE TREATMENT OF VIRAL INFECTIONS
  申请人：BUSATH David D.

  公开号：US20170128489A1

  公开（公告）日：2017-05-11

  Organo-transition metal complexes possess anti-viral inhibitory activity against influenza A, including the S3 IN mutant. The organo-transition metal complexes include a transition metal and at least one ligand based on the structure of an M2 proton channel blocker. Compounds and pharmaceutical compositions are useful for treating viruses such as influenza A.
• Pentacyclo[5.4.0.02,6.03,10.05,9]undecylamines. Synthesis and pharmacology
  作者：DW Oliver、TG Dekker、FO Snyckers

  DOI：10.1016/0223-5234(91)90097-7

  日期：1991.6

  The synthesis and biological activity of a series of pentacyclo[5.4.0.0(2,6).0(3.10).0(5.9)]undecyl-8-amino derivatives are described. The activity of the compounds to antagonize the reserpine induced catatonia (anticataleptic) and their ability to reduce the oxotremorine induced tremor and salivation were determined in order to evaluate their potential as anti-Parkinson agents. Promising anticataleptic and mild to weak anticholinergic activities were observed for these compounds. The influence of substituents is discussed.