2-[2]quinolyl-1-(4-dimethylamino-phenyl)-ethanol | 102081-11-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[2]quinolyl-1-(4-dimethylamino-phenyl)-ethanol
• 英文别名: 2-[2]Chinolyl-1-(4-dimethylamino-phenyl)-aethanol；1-[4-(Dimethylamino)phenyl]-2-quinolin-2-ylethanol
• CAS: 102081-11-8
• 化学式: C₁₉H₂₀N₂O
• 分子量: 292.381
• InChiKey: GKEOQBCCYRZLGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  36.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[2]quinolyl-1-(4-dimethylamino-phenyl)-ethanol 在 甲基磺酰氯 、 三乙胺 作用下， 以80%的产率得到2-(p-dimethylaminostyryl)quinoline
  参考文献：
  名称：

  Biological evaluation of substituted quinolines

  摘要：

  Several quinolines were synthesized and evaluated in vitro against several parasites (Trypanosoma brucei, T. cruzi, Leishmania infantum, L. amazonensis, Plasmodium falciparum). Then, they were evaluated in vitro (at 10 muM), against HTLV-1 transformed cells. A few of them displayed interesting activities, comparable to the reference drugs. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.05.026
• 作为产物：
  描述：

  2-甲基喹啉 、 苯基锂 在 乙醚 作用下， 生成 2-[2]quinolyl-1-(4-dimethylamino-phenyl)-ethanol
  参考文献：
  名称：

  p-Dimethylaminophenylquinaldylcarbinol

  摘要：

  DOI：

  10.1021/ja01117a502

文献信息

• Biological evaluation of substituted quinolines
  作者：Xavier Franck、Alain Fournet、Eric Prina、Renaud Mahieux、Reynald Hocquemiller、Bruno Figadère

  DOI：10.1016/j.bmcl.2004.05.026

  日期：2004.7

  Several quinolines were synthesized and evaluated in vitro against several parasites (Trypanosoma brucei, T. cruzi, Leishmania infantum, L. amazonensis, Plasmodium falciparum). Then, they were evaluated in vitro (at 10 muM), against HTLV-1 transformed cells. A few of them displayed interesting activities, comparable to the reference drugs. (C) 2004 Elsevier Ltd. All rights reserved.
• p-Dimethylaminophenylquinaldylcarbinol
  作者：F. W. Bergstrom、Arthur Furst

  DOI：10.1021/ja01117a502

  日期：1953.11