6-异丙基-3,9-二甲基-1,4-二氧杂螺[4.5]癸烷-2-酮 | 831213-72-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 6-异丙基-3,9-二甲基-1,4-二氧杂螺[4.5]癸烷-2-酮
• 英文名称: 3,9-Dimethyl-6-(1-methylethyl)-1,4-dioxaspiro(4.5)decan-2-one
• 英文别名: 2,9-dimethyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-one
• CAS: 831213-72-0
• 化学式: C₁₃H₂₂O₃
• 分子量: 226.31
• InChiKey: VUWCGGOBVYCOMA-UHFFFAOYSA-N

物化性质

• 沸点：
  317.3±17.0 °C(Predicted)
• 密度：
  1.03±0.1 g/cm3(Predicted)
• LogP：
  2.53
• 物理描述：
  Colourless liquid; Minty aroma
• 溶解度：
  Slightly soluble in water; soluble in fats
• 折光率：
  1.458-1.461

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• ALKYL-SUBSTITUTED TETRAHYDROPYRANS AS FLAVORING SUBSTANCES
  申请人：Oertling Heiko

  公开号：US20100226864A1

  公开（公告）日：2010-09-09

  The present invention relates to alkyl-substituted tetrahydropyrans, mixtures containing these alkyl-substituted tetrahydropyrans, their respective use and corresponding flavored products.

  本发明涉及烷基取代的四氢吡喃，含有这些烷基取代的四氢吡喃的混合物，它们的相应用途以及相应的风味产品。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• SYNTHETIC SPILANTHOL AND USE THEREOF
  申请人：Lombardo Louis

  公开号：US20100184863A1

  公开（公告）日：2010-07-22

  The present application provides a synthetic spilanthol flavor composition that includes (2E,6Z,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide. The synthetic spilanthol composition can also contain, and at least one of (2E, 6E, 8E)-N-(2-methylpropyl)-2,6,8-decatrienamide and (2E, 6Z, 8Z)-N-(2-methylpropyl)-2,6,8-decatrienamide, the (N-(2-methylpropyl)-2,6,8-decatrienamide being present in amounts effective to impart a salivating or tingle effect while reducing the perception of off notes, as compared to the off-notes perceived upon consumption of natural spilanthol (e.g. spilanthol obtained from jambu oleoresin). Methods of increasing salivation and/or providing a tingling sensation upon consuming an orally consumable product that include adding to the product a synthetic spilanthol flavor composition are also provided. Synthetic spilanthol flavor compositions can be added to orally consumed products, such as, but not limited to, foods, beverages, pharmaceuticals, nutraceuticals, or therapeutic compositions, oral personal care products, gums (e.g. chewing gum or bubble gum), candy or lozenges.

  本申请提供一种合成的牙齿花酚香味组合物，其中包括（2E，6Z，8E）-N-（2-甲基丙基）-2，6，8-癸烯酰胺。合成的牙齿花酚组合物还可以包含至少一种（2E，6E，8E）-N-（2-甲基丙基）-2，6，8-癸烯酰胺和（2E，6Z，8Z）-N-（2-甲基丙基）-2，6，8-癸烯酰胺，其中（N-（2-甲基丙基）-2，6，8-癸烯酰胺）的含量有效地赋予口腔产生流口水或刺痛的效果，同时减少了与天然牙齿花酚（例如从jambu oleoresin获得的牙齿花酚）消费时感知到的异味。还提供了通过向可口服产品中添加合成的牙齿花酚香味组合物来增加口腔分泌和/或提供刺痛感的方法。合成的牙齿花酚香味组合物可以添加到口服产品中，例如但不限于食品、饮料、药品、保健品或治疗组合物、口腔个人护理产品、口香糖（例如嚼口香糖或泡泡糖）、糖果或含片中。
• Flavor and fragrance composition
  申请人：Aida Takashi

  公开号：US20090275669A1

  公开（公告）日：2009-11-05

  A flavor and fragrance composition with a cooling sensation effect comprising 1-(2-hydroxy-4-methylcyclohexyl)ethanone represented by the formula (1). The flavor and fragrance composition is added to a beverage or food product, a fragrance or cosmetic product, a daily utensil product, an oral composition, or a pharmaceutical product in the range of 0.0001 to 20% by weight to the total weight of the flavor and fragrance composition added.

  一种具有冰凉感效果的香味和香料组合物，包括由式（1）表示的1-(2-羟基-4-甲基环己基)乙酮。该香味和香料组合物被添加到饮料或食品产品、香水或化妆品产品、日用品产品、口腔组合物或制药产品中，添加量为香味和香料组合物总重量的0.0001至20%。