6-methyl-4-(2,4-dichlorophenyl)-3,4-dihydroquinolin-2(1H)-one | 312696-67-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-methyl-4-(2,4-dichlorophenyl)-3,4-dihydroquinolin-2(1H)-one
• 英文别名: 4-(2,4-dichlorophenyl)-6-methyl-3,4-dihydroquinolin-2(1H)-one；4-(2,4-dichlorophenyl)-6-methyl-3,4-dihydro-1H-quinolin-2-one
• CAS: 312696-67-6
• 化学式: C₁₆H₁₃Cl₂NO
• 分子量: 306.191
• InChiKey: DVDKBJYHUHQBRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  丙二酸环(亚)异丙酯 、 乙烷,三氯氟- 、 2,4-二氯苯甲醛 以 溶剂黄146 为溶剂， 反应 0.25h， 以85%的产率得到6-methyl-4-(2,4-dichlorophenyl)-3,4-dihydroquinolin-2(1H)-one
  参考文献：
  名称：

  Highly Efficient Synthesis of 3,4-Dihydro-2(1H)-quinolinone Derivatives under Microwave Heating

  摘要：

  A sequential three-component reaction of aromatic aldehydes with aromatic amine, and Meldrum's acid in EtOH under microwave irradiation has been developed. In this one-pot reaction, a series of 3,4-dihydro-2(1H)-quinolinone derivatives were synthesized with high chemical yields. The present green synthesis shows several advantages including operational simplicity and fast reaction rate, which makes it a useful and attractive process for library generation for drug discovery.

  DOI：

  10.3987/com-12-12489