(2,2,2',2'-tetramethyl-[4,4']bi[[1,3]-dioxolanyl]-5-yl)-methanol | 1219342-21-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2,2,2',2'-tetramethyl-[4,4']bi[[1,3]-dioxolanyl]-5-yl)-methanol
• 英文别名: [5-(2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyl-1,3-dioxolan-4-yl]methanol
• CAS: 1219342-21-8
• 化学式: C₁₁H₂₀O₅
• 分子量: 232.277
• InChiKey: FBIWGPWXTDOFQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2,2,2',2'-tetramethyl-[4,4']bi[[1,3]-dioxolanyl]-5-yl)-methanol 在 吡啶 、 盐酸 、 sodium hydride 作用下， 以 四氢呋喃 、 甲醇 、 水 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 18.0h， 生成 dixylitol diacrylate
  参考文献：
  名称：

  SMO-CRISPR-mediated apoptosis in CD133-targeted cancer stem cells and tumor growth inhibition

  摘要：

  DOI：

  10.1016/j.jconrel.2023.03.023
• 作为产物：
  描述：

  Adonitol 、 丙酮 在 硫酸 、 copper(II) sulfate 作用下， 生成 (2,2,2',2'-tetramethyl-[4,4']bi[[1,3]-dioxolanyl]-5-yl)-methanol
  参考文献：
  名称：

  US2023/98307

  摘要：

  公开号：

文献信息

• METHOD FOR PRODUCING MULTI-ARM TYPE POLYETHYLENE GLYCOL DERIVATIVE
  申请人：NOF CORPORATION

  公开号：US20210024692A1

  公开（公告）日：2021-01-28

  A method for producing a multi-arm type polyethylene glycol derivative, which includes carrying out the following in order: Step (A): protecting an even number of hydroxyl groups, while leaving only the hydroxyl group at the 1-position of a polyhydric alcohol having an odd number of hydroxyl groups, other than the hydroxyl group at the 1-position by cyclic benzylidene acetalization, Step (B): linking two molecules of the compound obtained in step (A) to a compound for introducing a specific linker by etherification reaction, Step (C): deprotecting the cyclic benzylidene acetal structure at the terminal of the compound obtained in step (B), Step (D): polymerizing 3 to 600 mol of ethylene oxide to each hydroxyl group of the compound obtained in step (C) to obtain a multi-arm type polyethylene glycol derivative, and Step (E): functionalizing the hydroxyl group at the terminal of the multi-arm type polyethylene glycol derivative obtained in step (D).

  一种制备多臂型聚乙二醇衍生物的方法，包括按顺序进行以下步骤：步骤（A）：通过环状苯甲醛缩醛化反应保护偶数个羟基，同时保留除1位置的羟基之外的奇数个羟基的多羟醇的羟基，步骤（B）：通过醚化反应将步骤（A）中获得的化合物的两个分子连接到引入特定连接剂的化合物上，步骤（C）：去除步骤（B）中获得的化合物末端的环状苯甲醛缩醛结构，步骤（D）：聚合3至600摩尔的乙氧基到步骤（C）中获得的化合物的每个羟基上，以获得多臂型聚乙二醇衍生物，步骤（E）：对步骤（D）中获得的多臂型聚乙二醇衍生物末端的羟基进行官能化。
• MULTIBRANCHED POLYOXYALKYLENE DERIVATIVE
  申请人：Sakanoue Kenji

  公开号：US20100029899A1

  公开（公告）日：2010-02-04

  An object of the present invention is to provide a novel multibranched polyoxyalkylene derivative, and an intermediate for the production thereof. Specifically, the object is to provide a multibranched polyoxyalkylene derivative which can keep a high activity of a bio-related substance modified with the multibranched polyoxyalkylene derivative and which can easily produce the modified substance; an intermediate thereof; and a bio-related substance to which the multibranched polyoxyalkylene derivative is bonded. The novel multibranched polyoxyalkylene derivative according to the invention is a polyoxyalkylene derivative (1) having a functional group reactive with a bio-related substance and the bio-related substance according to the invention has a structure modified with the above polyoxyalkylene derivative (1) by a reaction. Furthermore, the intermediate for the production of the novel multibranched polyoxyalkylene derivative according to the invention is a polyoxyalkylene derivative (A). wherein A 1 O and A 2 O independently represent an oxyalkylene group having 2 to 4 carbon atoms, m represents 20 to 500, n represents 15 to 700, R represents a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms, X represents a functional group reactive with a bio-related substance, and X 1 represents a hydroxyl group which may be protected.

  本发明的目的是提供一种新型的多支链聚氧烷衍生物及其制备中间体。具体而言，本发明旨在提供一种多支链聚氧烷衍生物，该衍生物可以保持与其修饰的生物相关物质的高活性，并且可以轻松地生产修饰后的物质；其制备中间体；以及与多支链聚氧烷衍生物结合的生物相关物质。本发明的新型多支链聚氧烷衍生物是一种具有与生物相关物质反应性功能团的聚氧烷衍生物(1)，而本发明的生物相关物质具有通过反应与上述聚氧烷衍生物(1)修饰的结构。此外，本发明的新型多支链聚氧烷衍生物的制备中间体是一种聚氧烷衍生物(A)。其中，A1O和A2O独立地表示具有2至4个碳原子的氧烷基，m表示20至500，n表示15至700，R表示氢原子或具有1至20个碳原子的碳氢基团，X表示与生物相关物质反应性的功能团，X1表示可能被保护的羟基。
• POLYOXYETHYLENE DERIVATIVE HAVING PLURAL HYDROXYL GROUPS AT TERMINAL END THEREOF
  申请人：Yoshioka Hiroki

  公开号：US20120322955A1

  公开（公告）日：2012-12-20

  A polyoxyethylene derivative represented by the formula (1): wherein a whole molecular weight of the polyoxyethylene derivative is 500 to 160,000; n is 5 to 3650; L 1 , L 2 , and L 3 each independently represent an alkylene group, a phenylene group, an ester bond, an amide bond, an ether bond, a urethane bond, a carbonate bond, a secondary amino group, or a combination thereof; X represents a functional group capable of reacting with a bio-related substance; Y represents a hydrophilic group having plural hydroxyl groups made from a residual group of xylitol or volemitol or a residual group of polyglycerin of trimer to 31-mer; Z represents a residual group of a compound having 2 to 5 active hydrogen atoms; b and c are as follows: 1≦b≦4, 1≦c≦4, and 2≦b+c≦5; and d and e each independently are 0 or 1.

  公式（1）所代表的聚氧乙烯衍生物，其整体分子量为500至160,000；n为5至3650；L1、L2和L3分别独立地表示烷基、苯基、酯键、酰胺键、醚键、脲键、碳酸酯键、二级氨基团或其组合；X表示能够与生物相关物质反应的官能团；Y表示具有由木糖醇或沃勒米托尔的剩余基团或三聚到31聚的聚甘油的剩余基团制成的复数羟基基团；Z表示具有2至5个活性氢原子的化合物的剩余基团；b和c分别为：1≦b≦4，1≦c≦4，且2≦b+c≦5；d和e各自独立地为0或1。
• Polymers, photoresist compositions and methods of forming photolithographic patterns
  申请人：Rohm and Haas Electronic Materials LLC

  公开号：EP2472326A1

  公开（公告）日：2012-07-04

  Provided are polymers that include a unit comprising a particular acetal moiety and a unit comprising a lactone moiety. Also provided are photoresist compositions containing such a polymer, substrates coated with the photoresist compositions and methods of forming photolithographic patterns. The polymers, compositions, methods and coated substrates find particular applicability in the manufacture of semiconductor devices.

  所提供的聚合物包括一个由特定缩醛分子组成的单元和一个由内酯分子组成的单元。此外，还提供了含有这种聚合物的光刻胶组合物、涂有光刻胶组合物的基底以及形成光刻图案的方法。这些聚合物、组合物、方法和涂覆基材特别适用于半导体器件的制造。
• Production method of polyoxyethylene derivative having plurality of hydroxyl groups at terminal
  申请人：NOF CORPORATION

  公开号：US10947343B2

  公开（公告）日：2021-03-16

  A method of producing a polyoxyethylene derivative (1): where L1 is a divalent linker, X is a functional group capable of reacting with a physiologically active substance, a is 1 or 2, and n is from 11 to 3,650. The method includes Step (A): protecting 4 or 6 hydroxyl groups in a polyhydric alcohol having 5 or 7 hydroxyl groups by cyclic benzylidene acetalization to obtain a compound having a hydroxyl group at a 1-position and a protective group of a cyclic benzylidene acetal structure; Step (B): polymerizing from 11 to 3,650 moles of ethylene oxide to the compound obtained in the step (A) to obtain a polyoxyethylene derivative; Step (C): converting the hydroxyl group at a terminal of the polyoxyethylene derivative to a functional group capable of reacting with a physiologically active substance; and Step (D): deprotecting the protective group of the polyoxyethylene derivative.

  一种生产聚氧乙烯衍生物（1）的方法： 其中 L1 为二价连接剂，X 为能与生理活性物质反应的官能团，a 为 1 或 2，n 为 11 至 3650。该方法包括步骤(A)：通过环亚苄基缩醛化，保护具有 5 或 7 个羟基的多元醇中的 4 或 6 个羟基，以获得具有 1 位羟基和环亚苄基缩醛结构的保护基团的化合物； 步骤(B)：将 11 至 3,650 摩尔环氧乙烷与步骤(A)中得到的化合物聚合，得到聚氧乙烯衍生物； 步骤(C)：将聚氧乙烯衍生物末端的羟基转化为能与生理活性物质反应的官能团；以及 步骤(D)：对聚氧乙烯衍生物的保护基进行脱保护。