6-碘-8-硝基喹啉 | 5552-46-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 6-碘-8-硝基喹啉
• 英文名称: 6-iodo-8-nitroquinoline
• CAS: 5552-46-5
• 化学式: C₉H₅IN₂O₂
• 分子量: 300.055
• InChiKey: MNONEVLFFGBYHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-碘-8-硝基喹啉 在 盐酸 、 铁粉 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以85%的产率得到6-碘-8-喹啉胺
  参考文献：
  名称：

  Preparation and Antifungal Activity of 3-Iodo- and 6-Iodo-8-quinolinols

  摘要：

  3-Iodo- and 6-Iodo-8-quinolinols were prepared and tested against six fungi: Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, Mucor cirinelloides, and Trichopkyton mentagrophytes in Sabouraud dextrose broth. A comparison with the previously known 5-iodo- and 7-iodo-8-quinolinols showed that the 6-iodo isomer was the most active.

  DOI：

  10.1007/s00706-002-0495-6
• 作为产物：
  描述：

  2-硝基苯胺 在 N-碘代丁二酰亚胺 、 arsenic(V) oxide 、 硫酸 作用下， 以 溶剂黄146 为溶剂， 反应 4.0h， 生成 6-碘-8-硝基喹啉
  参考文献：
  名称：

  Preparation and Antifungal Activity of 3-Iodo- and 6-Iodo-8-quinolinols

  摘要：

  3-Iodo- and 6-Iodo-8-quinolinols were prepared and tested against six fungi: Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, Mucor cirinelloides, and Trichopkyton mentagrophytes in Sabouraud dextrose broth. A comparison with the previously known 5-iodo- and 7-iodo-8-quinolinols showed that the 6-iodo isomer was the most active.

  DOI：

  10.1007/s00706-002-0495-6

文献信息

• Preparation and Antifungal Activity of 3-Iodo- and 6-Iodo-8-quinolinols
  作者：Herman Gershon、Donald D. Clarke、John J. McMahon、Muriel Gershon

  DOI：10.1007/s00706-002-0495-6

  日期：2002.9.1

  3-Iodo- and 6-Iodo-8-quinolinols were prepared and tested against six fungi: Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, Mucor cirinelloides, and Trichopkyton mentagrophytes in Sabouraud dextrose broth. A comparison with the previously known 5-iodo- and 7-iodo-8-quinolinols showed that the 6-iodo isomer was the most active.

表征谱图