[(1S,2R,5R,6R,7S,8R,10R)-10-[(2-hydroxyacetyl)amino]-1,5-dimethyl-8-propan-2-yl-11-oxatricyclo[6.2.1.02,6]undecan-7-yl] (E)-3-phenylprop-2-enoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [(1S,2R,5R,6R,7S,8R,10R)-10-[(2-hydroxyacetyl)amino]-1,5-dimethyl-8-propan-2-yl-11-oxatricyclo[6.2.1.02,6]undecan-7-yl] (E)-3-phenylprop-2-enoate
• 化学式: C₂₆H₃₅NO₅
• 分子量: 441.6
• InChiKey: XJXBTAKQYJGWLC-RRYXBOBMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  84.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• AZA-EPOXY-GUAIANE DERIVATIVES AND TREATMENT OF CANCER
  申请人：THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV

  公开号：US20160347764A1

  公开（公告）日：2016-12-01

  Disclosed is a compound of formula (I) or formula (II): (Formulas should be inserted here) wherein R 1 -R 6 are as defined herein. Also disclosed are a pharmaceutical composition comprising such a compound and a method of treating or preventing cancer in a mammal in need thereof, comprising administering to the mammal a compound of formula (I) or formula (II).
• US9676788B2
  申请人：——

  公开号：US9676788B2

  公开（公告）日：2017-06-13