[(2R,3R,4R,5S)-5-acetamido-3,4-dihydroxypiperidin-2-yl]methyl hydrogen sulfate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: [(2R,3R,4R,5S)-5-acetamido-3,4-dihydroxypiperidin-2-yl]methyl hydrogen sulfate
• 化学式: C₈H₁₆N₂O₇S
• 分子量: 284.29
• InChiKey: BXPMRCYNKVCFLL-LXGUWJNJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.6
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  154
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Sugar Derivatives Comprising Sulfur-Containing Moieties And Methods Of Making Same and Methods of Using the Same for the Treatment of MPS IIIC
  申请人：Amicus Therapeutics, Inc.

  公开号：US20150225420A1

  公开（公告）日：2015-08-13

  Described herein are modified sugar, iminosugar and azasugar compounds and methods of making same. One or more of these modified compounds contain sulfates, sulfites, sulfamates and/or sulfonamides. Also described are pharmaceutical compositions/formulations comprising these compounds, as well as methods using these modified sugar compounds for the treatment of MPS IIIC (also known as Sanfilippo Type C).
• Sugar Derivatives Comprising Sulfur-Containing Moieties And Methods Of Making Same And Methods Of Using The Same For The Treatment Of MPS IIIC
  申请人：Amicus Therapeutics, Inc.

  公开号：US20170190665A1

  公开（公告）日：2017-07-06

  Described herein are modified sugar, iminosugar and azasugar compounds and methods of making same. One or more of these modified compounds contain sulfates, sulfites, sulfamates and/or sulfonamides. Also described are pharmaceutical compositions/formulations comprising these compounds, as well as methods using these modified sugar compounds for the treatment of MPS IIIC (also known as Sanfilippo Type C).
• US9598438B2
  申请人：——

  公开号：US9598438B2

  公开（公告）日：2017-03-21