1-{[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]methyl}-1H-naphtho[2,3-d][1,2,3]triazole | 1449194-90-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-{[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]methyl}-1H-naphtho[2,3-d][1,2,3]triazole
• 英文别名: 3-[(1-Phenyltetrazol-5-yl)sulfonylmethyl]benzo[f]benzotriazole；3-[(1-phenyltetrazol-5-yl)sulfonylmethyl]benzo[f]benzotriazole
• CAS: 1449194-90-4
• 化学式: C₁₈H₁₃N₇O₂S
• 分子量: 391.413
• InChiKey: BZMWJWFZMKLBLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  117
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-乙基丁醛 、 1-{[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]methyl}-1H-naphtho[2,3-d][1,2,3]triazole 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 0.33h， 以56%的产率得到
  参考文献：
  名称：

  Modular Synthesis of N-Vinyl Benzotriazoles

  摘要：

  A modular approach to N1-vinyl benzotriazoles by azide-aryne cycloadditions and Julia-Kocienski reactions is described. Reactions of azidomethyl phenyl-1H-tetrazol-5-yl (PT) sulfide with arynes gave methyl(PT-sulfanyl)-substituted benzotriazoles in 68-89% yields. Oxidation of the sulfides to the sulfones gave the benzotriazole-substituted Julia-Kocienski reagents. Olefination reactions of aldehydes and a ketone with reagents derived from benzyne, 2,3-naphthyne, and 4,5-dimethoxybenzyne precursors proceeded to give various NI-vinyl benzotriazole derivatives. Olefination stereoselectivities are tunable for electron-rich aldehydes, but not for electron-deficient aldehydes and alkanals, where they proceed with good to excellent Z-stereoselectivity.

  DOI：

  10.1021/ol401661j
• 作为产物：
  描述：

  1-苯基-5-巯基四氮唑 在 potassium fluoride 、 sodium azide 、 18-冠醚-6 、 hexaammonium heptamolybdate tetrahydrate 、 双氧水 、 potassium carbonate 、 sodium iodide 作用下， 以 水 、 N,N-二甲基甲酰胺 、 丙酮 、 乙腈 为溶剂， 反应 42.0h， 生成 1-{[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]methyl}-1H-naphtho[2,3-d][1,2,3]triazole
  参考文献：
  名称：

  Modular Synthesis of N-Vinyl Benzotriazoles

  摘要：

  A modular approach to N1-vinyl benzotriazoles by azide-aryne cycloadditions and Julia-Kocienski reactions is described. Reactions of azidomethyl phenyl-1H-tetrazol-5-yl (PT) sulfide with arynes gave methyl(PT-sulfanyl)-substituted benzotriazoles in 68-89% yields. Oxidation of the sulfides to the sulfones gave the benzotriazole-substituted Julia-Kocienski reagents. Olefination reactions of aldehydes and a ketone with reagents derived from benzyne, 2,3-naphthyne, and 4,5-dimethoxybenzyne precursors proceeded to give various NI-vinyl benzotriazole derivatives. Olefination stereoselectivities are tunable for electron-rich aldehydes, but not for electron-deficient aldehydes and alkanals, where they proceed with good to excellent Z-stereoselectivity.

  DOI：

  10.1021/ol401661j