2,5-anhydro-1,3-dideoxy-D-ribo-hexitol | 82165-72-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,5-anhydro-1,3-dideoxy-D-ribo-hexitol
• 英文别名: (2R,3S,5S)-2-(Hydroxymethyl)-5-methyltetrahydrofuran-3-ol；(2R,3S,5S)-2-(hydroxymethyl)-5-methyloxolan-3-ol
• CAS: 82165-72-8
• 化学式: C₆H₁₂O₃
• 分子量: 132.159
• InChiKey: VYMGPBXXQAUPSO-HCWXCVPCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2S,4R,5S)-(4-hydroxy-5-methyltetrahydrofuran-2-yl)methanol 、 2,5-anhydro-1,3-dideoxy-D-ribo-hexitol 、 对甲苯磺酰氯 生成 2,5-anhydro-1,4-dideoxy-6-O-(p-tolylsulphonyl)-D-ribo-hexitol
  参考文献：
  名称：

  （+）-毒蕈碱的简单立体定向合成

  摘要：

  描述了由-甘露糖醇经由2，5-脱水-葡萄糖醇的毒性原理（+）-毒蕈碱的高产率立体定向合成。

  DOI：

  10.1016/s0040-4039(00)93174-5
• 作为产物：
  描述：

  2,5-anhydro-4,5-di-O-benzoyl-1,3-O-isopropylidene-D-glucitol 在 lithium aluminium tetrahydride 、 sodium methylate 作用下， 以 四氢呋喃 、 吡啶 、 甲醇 、 氯仿 、 苯 为溶剂， 反应 115.0h， 生成 2,5-anhydro-1,3-dideoxy-D-ribo-hexitol
  参考文献：
  名称：

  Mubarak, Azeez M.; Brown, Daniel M., Journal of the Chemical Society. Perkin transactions I, 1982, p. 809 - 814

  摘要：

  DOI：

文献信息

• ANTIVIRAL THERAPEUTIC AGENTS
  申请人：Babu Yarlagadda S.

  公开号：US20090227524A1

  公开（公告）日：2009-09-10

  The invention provides compounds of Formula I: as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of Formula (I) are useful as anti-viral agents and/or as anti-cancer agents.

  该发明提供了如下的化合物I的公式，以及包含这些化合物的药物组合物，以及用于制备这些化合物的有用的合成方法和中间体。公式（I）的化合物可用作抗病毒剂和/或抗癌剂。
• Therapeutic Furopyrimidines and Thienopyrimidines
  申请人：Babu Yarlagadda S.

  公开号：US20080300200A1

  公开（公告）日：2008-12-04

  The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula I, II, and III are useful as anti-viral agents and/or as anti-cancer agents.

  本发明提供了公式I、II和III所描述的化合物，以及包含这些化合物的药物组合物，以及用于制备这些化合物的合成方法和中间体。公式I、II和III的化合物可用作抗病毒剂和/或抗癌剂。
• 3,5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED-3H-OXAZOLO AND 3H-THIAZOLO[4,5-d]PYRIMIDIN-2-ONE COMPOUNDS AND PRODRUGS THEREOF
  申请人：Webber Stephen E.

  公开号：US20110275589A1

  公开（公告）日：2011-11-10

  The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions containing them, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds and prodrugs.

  本发明涉及具有免疫调节活性的3,5-二取代和3,5,7-三取代-3H-噁唑并[4,5-d]嘧啶-2-酮化合物及其前药。本发明还涉及使用此类化合物及其前药的治疗或预防用途，以及含有它们的制药组合物和通过给予这些化合物和前药的有效量来治疗本文所述疾病和疾病的方法。
• 3,5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED-3H-OXAZOLO AND 3H-THIAZOLO[4,5-D]PYRIMIDIN-2-ONE COMPOUNDS AND PRODRUGS THEREOF
  申请人：Webber Stephen E.

  公开号：US20120121541A1

  公开（公告）日：2012-05-17

  The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions containing them, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds and prodrugs.

  本发明涉及具有免疫调节活性的3,5-二取代和3,5,7-三取代-3H-噁唑和3H-噻唑[4,5-d]嘧啶-2-酮化合物及其前药。本发明还涉及使用这些化合物和前药的治疗或预防用途，以及含有它们的制药组合物，并通过给予这些化合物和前药的有效剂量来治疗本文所述的疾病和障碍的方法。
• THERAPEUTIC FUROPYRIMIDINES AND THIENOPYRIMIDINES
  申请人：Babu Yarlagadda S.

  公开号：US20120213735A1

  公开（公告）日：2012-08-23

  The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula I, II, and III are useful as anti-viral agents and/or as anti-cancer agents.

  本发明提供了式I、II和III的化合物，以及包含该化合物的药物组合物，以及用于制备该化合物的合成方法和中间体。式I、II和III的化合物可用作抗病毒剂和/或抗癌剂。