2,2-dimesityl-1-<(bisdimethylamino)phosphoryl>ethenol | 134335-05-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2,2-dimesityl-1-<(bisdimethylamino)phosphoryl>ethenol
• 英文别名: 1-[bis(dimethylamino)phosphoryl]-2,2-bis(2,4,6-trimethylphenyl)ethenol
• CAS: 134335-05-0
• 化学式: C₂₄H₃₅N₂O₂P
• 分子量: 414.528
• InChiKey: PQKWHGLRQBLBGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.13
• 重原子数：
  29.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  43.78
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  六甲基磷酰三胺 、 bis(mesityl)ketene 在 甲基锂 作用下， 生成 2,2-dimesityl-vinyl alcohol 、 N-ethyl-N-methyldimesitylacetamide 、 2,2-dimesityl-1-<(bisdimethylamino)phosphoryl>ethenol 、 2,2-dimesitylvinyl dimesitylacetate
  参考文献：
  名称：

  Formation of .alpha.-[bis(dimethylamino)phosphoryl]-substituted stable enols and N,N-dialkyl diarylacetamides from diarylketenes and methyllithium in hexamethyl phosphoric triamide

  摘要：

  The reaction of an MeLi/HMPA mixture in ether with dimesityl- and mesitylphenylketene yielded the enols MesC(Ar) = C(OH)PO(NMe2)2 and MesC(Ar) = CHOH and the amides MesCH(Ar)CON(Me)R (Ar = Mes, Ph; R = Me, Et) together with other products. An initial cleavage of the HMPA by the MeLi, followed by addition of the formed anionic species (Me2N)2PO-, Me2N-, or MeN-Et to the diarylketene, is proposed.

  DOI：

  10.1021/jo00013a031

文献信息

• Formation of .alpha.-[bis(dimethylamino)phosphoryl]-substituted stable enols and N,N-dialkyl diarylacetamides from diarylketenes and methyllithium in hexamethyl phosphoric triamide
  作者：Ella B. Nadler、Elana S. Zipory、Zvi Rappoport

  DOI：10.1021/jo00013a031

  日期：1991.6

  The reaction of an MeLi/HMPA mixture in ether with dimesityl- and mesitylphenylketene yielded the enols MesC(Ar) = C(OH)PO(NMe2)2 and MesC(Ar) = CHOH and the amides MesCH(Ar)CON(Me)R (Ar = Mes, Ph; R = Me, Et) together with other products. An initial cleavage of the HMPA by the MeLi, followed by addition of the formed anionic species (Me2N)2PO-, Me2N-, or MeN-Et to the diarylketene, is proposed.