N-Z-Glutamylphenylalanin | 987-84-8

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 苯丙氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Z-Glutamylphenylalanin
• 英文别名: N-(N-benzyloxycarbonyl-α-glutamyl)-phenylalanine；N-Benzyloxycarbonyl-α-glutamyl=>phenylalanin；N-(N-Benzyloxycarbonyl-α-glutamyl)-phenylalanin；3-Phenyl-N-(N-((phenylmethoxy)carbonyl)-L-alpha-glutamyl)-L-alanine；5-[(1-carboxy-2-phenylethyl)amino]-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acid
• CAS: 987-84-8
• 化学式: C₂₂H₂₄N₂O₇
• 分子量: 428.442
• InChiKey: ZORDBMVWKMEZAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  31
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  142
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-Z-Glutamylphenylalanin 在 甲醇 、 钯 、 溶剂黄146 作用下， 生成 N-glutamyl phenylalanine
  参考文献：
  名称：

  Lautsch; Schroeder, Monatshefte fur Chemie, 1957, vol. 88, p. 432,456

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 生成 N-Z-Glutamylphenylalanin
  参考文献：
  名称：

  Lautsch; Schroeder, Monatshefte fur Chemie, 1957, vol. 88, p. 432,456

  摘要：

  DOI：

文献信息

• Novel antibacterial agents
  申请人：Christensen G. Burton

  公开号：US20070134729A1

  公开（公告）日：2007-06-14

  This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

  本发明涉及一种新型多结合化合物（药剂），其为抗菌剂。该发明的多结合化合物由2-10个配体通过连接剂或连接剂共价连接而成，其中每个单价（即未连接的）配体具有与细胞壁生物合成和代谢中的酶、合成细菌细胞壁和/或细菌细胞表面的前体有结合能力，从而干扰细胞壁的合成和/或代谢。特别地，本发明的多结合化合物由2-10个配体通过连接剂或连接剂共价连接而成，其中每个配体具有能够结合青霉素结合蛋白、横向肽酶酶、横向肽酶酶底物、β-内酰胺酶、青霉素酶、头孢菌素酶、横向转移酶酶或横向转移酶酶底物的配体结构域。优选地，配体选自β-内酰胺类或糖肽类抗菌剂。
• GPCR Ligands Identified by Computational Modeling
  申请人：Parrill-Baker Abby L.

  公开号：US20090029949A1

  公开（公告）日：2009-01-29

  Disclosed are pharmacophores for developing and screening compounds having G-protein-coupled receptor antagonist activity, including LPA 1 , LPA 2 , LPA 3 and S1P antagonists. These compositions have therapeutic benefit in the fields of cancer chemotherapy, cardiovascular disease prevention, and fertility protective agents during radiation and chemotherapy.
• Lautsch; Schroeder, Monatshefte fur Chemie, 1957, vol. 88, p. 432,456
  作者：Lautsch、Schroeder

  DOI：——

  日期：——