Condelphine | 7633-69-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Condelphine
• 英文别名: [(1S,2R,3R,4S,5R,6S,8S,9S,13S,16S,17R)-11-ethyl-8,16-dihydroxy-6-methoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] acetate
• CAS: 7633-69-4
• 化学式: C₂₅H₃₉NO₆
• 分子量: 449.6
• InChiKey: ZEBMMHUDQRRILP-WZSMAATHSA-N

物化性质

• 熔点：
  158～159℃

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  88.5
• 氢给体数：
  2
• 氢受体数：
  7

安全信息

• 危险品运输编号：
  UN 1544 6.1/PG 2
• 安全说明：
  S22,S36/37/39,S45

文献信息

• METHODS AND COMPOSITIONS FOR TREATING INFECTION
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US20150238473A1

  公开（公告）日：2015-08-27

  Provided herein are compositions and methods for treating or preventing infection.

  本文提供了用于治疗或预防感染的组合物和方法。
• PARAKERATOSIS INHIBITOR, PORE-SHRINKING AGENT AND SKIN PREPARATION FOR EXTERNAL USE
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP1550459A1

  公开（公告）日：2005-07-06

  It is intended to provide a substance having an effect of shrinking pores by analyzing the mechanism of making pores perceptible and compositions such as a skin preparation for external use which exerts the above effect to thereby make pores imperceptible. As means for solving these problems, there are provided a parakeratosis inhibitor and a pore-shrinking agent comprising an antagonist to an excitatory cell receptor, for example, a glutamate receptor such as N-methyl-D-aspartic acid receptor or an ATP receptor such as P2X receptor, or an agonist to an inhibitory cell receptor such as a γ-aminobutyrate receptor such as bicuculline-sensitive receptor having the Cl-channel therein or glycine receptor, as well as a skin preparation for external use aiming at inhibiting parakeratosis and a skin preparation for external use aiming at shrinking pores each containing such an antagonist to an excitatory cell receptor or an agonist to an inhibitory cell receptor as described above. Owing to the effects of inhibiting parakeratosis and shrinking pores, the skin can be maintained in a healthy state without perceptible pores.

  本发明旨在提供一种通过分析使毛孔可感知的机理而具有收缩毛孔效果的物质，以及可发挥上述效果从而使毛孔不可感知的外用皮肤制剂等组合物。作为解决这些问题的方法，提供了一种角化抑制剂和毛孔收缩剂，其中包括兴奋性细胞受体的拮抗剂，例如谷氨酸受体，如 N-甲基-D-天冬氨酸受体或 ATP 受体，如 P2X 受体、或抑制性细胞受体的激动剂，如γ-氨基丁酸受体，如具有 Cl-通道的双谷氨酸敏感受体或甘氨酸受体，以及旨在抑制角化不全的外用皮肤制剂和旨在收缩毛孔的外用皮肤制剂，每种制剂都含有上述兴奋性细胞受体的拮抗剂或抑制性细胞受体的激动剂。由于具有抑制角化不全和收缩毛孔的作用，皮肤可以保持健康状态，不会出现明显的毛孔。
• Methods and compositions for treating infection
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US10004701B2

  公开（公告）日：2018-06-26

  Provided herein are compositions and methods for treating or preventing infection.

  本文提供了用于治疗或预防感染的组合物和方法。
• Compositions and methods for treating anxiety
  申请人：Miwa Julie M.

  公开号：US10603304B1

  公开（公告）日：2020-03-31

  A method of treating anxiety in a subject having a mutation in the lynx2 gene and suffering from anxiety, includes administering to the subject an effective amount of a nicotinic blocker and/or an effective amount of a selective antagonist of the nicotinic acetylcholine receptor alpha-7 (nAChR α7) subunit.

  一种治疗具有猞猁2基因突变并患有焦虑症的受试者的焦虑症的方法，包括向受试者施用有效量的烟碱阻断剂和/或有效量的烟碱乙酰胆碱受体α-7（nAChR α7）亚基选择性拮抗剂。
• Parakeratosis inhibitor, pore-shrinking agent and skin preparation for external use
  申请人：Katsuta Yuji

  公开号：US20050152930A1

  公开（公告）日：2005-07-14

  It is intended to provide a substance having an effect of shrinking pores by analyzing the mechanism of making pores perceptible and compositions such as a skin preparation for external use which exerts the above effect to thereby make pores imperceptible. As means for solving these problems, there are provided a parakeratosis inhibitor and a pore-shrinking agent comprising an antagonist to an excitatory cell receptor, for example, a glutamate receptor such as N-methyl-D-aspartic acid receptor or an ATP receptor such as P2X receptor, or an agonist to an inhibitory cell receptor such as a γ-aminobutyrate receptor such as bicuculline-sensitive receptor having the Cl— channel therein or glycine receptor, as well as a skin preparation for external use aiming at inhibiting parakeratosis and a skin preparation for external use aiming at shrinking pores each containing such an antagonist to an excitatory cell receptor or an agonist to an inhibitory cell receptor as described above. Owing to the effects of inhibiting parakeratosis and shrinking pores, the skin can be maintained in a healthy state without perceptible pores.

  本发明旨在提供一种通过分析使毛孔可感知的机理而具有收缩毛孔效果的物质，以及可发挥上述效果从而使毛孔不可感知的外用皮肤制剂等组合物。作为解决这些问题的方法，提供了一种角化抑制剂和毛孔收缩剂，其中包括兴奋性细胞受体的拮抗剂，例如谷氨酸受体，如 N-甲基-D-天冬氨酸受体或 ATP 受体，如 P2X 受体、或抑制性细胞受体的激动剂，如γ-氨基丁酸受体，如具有 Cl- 通道的双谷氨酸敏感受体或甘氨酸受体，以及旨在抑制角化病的外用皮肤制剂和旨在收缩毛孔的外用皮肤制剂，每种制剂都含有上述兴奋性细胞受体的拮抗剂或抑制性细胞受体的激动剂。由于具有抑制角化不全和收缩毛孔的作用，皮肤可以保持健康状态，不会出现明显的毛孔。