13-[4-(2-fluorobenzyloxy)phenyl]-7,13-dihydro-12H-benzo[f]indeno[1,2-b]quinolin-12-one | 447456-63-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 13-[4-(2-fluorobenzyloxy)phenyl]-7,13-dihydro-12H-benzo[f]indeno[1,2-b]quinolin-12-one
• 英文别名: 13-{4-[(2-fluorobenzyl)oxy]phenyl}-7,13-dihydro-12H-benzo[f]indeno[1,2-b]quinolin-12-one；12-[4-[(2-fluorophenyl)methoxy]phenyl]-2-azapentacyclo[11.8.0.03,11.04,9.014,19]henicosa-1(13),3(11),4,6,8,14,16,18,20-nonaen-10-one
• CAS: 447456-63-5
• 化学式: C₃₃H₂₂FNO₂
• 分子量: 483.542
• InChiKey: QGUYZJWCMUQQLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  37
• 可旋转键数：
  4
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  13-[4-(2-fluorobenzyloxy)phenyl]-7,13-dihydro-12H-benzo[f]indeno[1,2-b]quinolin-12-one 以 硝基苯 为溶剂， 反应 8.0h， 以79%的产率得到13-[4-(2-fluorobenzyloxy)phenyl]-12H-benzo[f]indeno[1,2-b]quinolin-12-one
  参考文献：
  名称：

  Condensation of fluorosubstituted benzaldehydes with amines and cyclic 1,3-diketones

  摘要：

  Condensation of fluorosubstituted benzaldehydes with 2-naphthyl or 6-quinolylamine and cyclic beta-diketones (,3-cyclohexanedione, dimedone, and 1,3-indandione) provided new fluoroderivatives of benzo[a]acridine, 4,7-phenanthroline, and benzo[f]indeno[1,2-b]quinoline. Forming in the course of the reaction fluorophenylmethylene-2-naphthyl-(or 6-quinolyl)amines, arylbis(cyclohexane-1,3-dion-2-yl)methanes, and 2-(fluorophenylmethylene)- 1,3-indandiones were isolated.

  DOI：

  10.1134/s107042800611011x
• 作为产物：
  描述：

  4-(2-氟苄氧基)苯甲醛 以 正丁醇 为溶剂， 反应 8.0h， 生成 13-[4-(2-fluorobenzyloxy)phenyl]-7,13-dihydro-12H-benzo[f]indeno[1,2-b]quinolin-12-one
  参考文献：
  名称：

  Condensation of fluorosubstituted benzaldehydes with amines and cyclic 1,3-diketones

  摘要：

  Condensation of fluorosubstituted benzaldehydes with 2-naphthyl or 6-quinolylamine and cyclic beta-diketones (,3-cyclohexanedione, dimedone, and 1,3-indandione) provided new fluoroderivatives of benzo[a]acridine, 4,7-phenanthroline, and benzo[f]indeno[1,2-b]quinoline. Forming in the course of the reaction fluorophenylmethylene-2-naphthyl-(or 6-quinolyl)amines, arylbis(cyclohexane-1,3-dion-2-yl)methanes, and 2-(fluorophenylmethylene)- 1,3-indandiones were isolated.

  DOI：

  10.1134/s107042800611011x

文献信息

• Condensation of fluorosubstituted benzaldehydes with amines and cyclic 1,3-diketones
  作者：N. G. Kozlov、K. N. Gusak

  DOI：10.1134/s107042800611011x

  日期：2006.11

  Condensation of fluorosubstituted benzaldehydes with 2-naphthyl or 6-quinolylamine and cyclic beta-diketones (,3-cyclohexanedione, dimedone, and 1,3-indandione) provided new fluoroderivatives of benzo[a]acridine, 4,7-phenanthroline, and benzo[f]indeno[1,2-b]quinoline. Forming in the course of the reaction fluorophenylmethylene-2-naphthyl-(or 6-quinolyl)amines, arylbis(cyclohexane-1,3-dion-2-yl)methanes, and 2-(fluorophenylmethylene)- 1,3-indandiones were isolated.