BOC-3-氨基-5-(FMOC-氨基)苯甲酸 | 779335-06-7

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 环羧酸
• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 中文名称: BOC-3-氨基-5-(FMOC-氨基)苯甲酸
• 英文名称: 3-(tert-butoxycarbonylamino)-5-(9H-fluoren-9-ylmethoxycarbonylamino)benzoic acid
• 英文别名: 3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxycarbonylamino]benzoic acid
• CAS: 779335-06-7
• 化学式: C₂₇H₂₆N₂O₆
• 分子量: 474.513
• InChiKey: KNYZSHDTFJANSS-UHFFFAOYSA-N

物化性质

• 沸点：
  596.3±50.0 °C(Predicted)
• 密度：
  1.337±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  BOC-3-氨基-5-(FMOC-氨基)苯甲酸 在 哌啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (4-nitrophenyl)sulfonyl 4-methoxybenzoate
  参考文献：
  名称：

  Microwave-Assisted Synthesis of Aryl Amide Bonds on Solid Phase

  摘要：

  A novel microwave-assisted synthesis of a library of triarylamides has been undertaken on the solid-phase.

  DOI：

  10.1080/00397910903370618
• 作为产物：
  描述：

  二碳酸二叔丁酯 、 3-amino-5-(9H-fluoren-9-ylmethoxycarbonylamino)benzoic acid 在 N,N-二异丙基乙胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 4.0h， 以51%的产率得到BOC-3-氨基-5-(FMOC-氨基)苯甲酸
  参考文献：
  名称：

  Microwave-Assisted Synthesis of Aryl Amide Bonds on Solid Phase

  摘要：

  A novel microwave-assisted synthesis of a library of triarylamides has been undertaken on the solid-phase.

  DOI：

  10.1080/00397910903370618

文献信息

• COMPOUNDS USEFUL IN PREPARING HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE
  申请人：Capon, Daniel J.

  公开号：EP3701971A1

  公开（公告）日：2020-09-02

  The present invention provides intermediate compounds containing a triazine or trans-cyclooctene group, useful in the preparation of compounds having the structure:         A-B-----Z wherein A is a biologically active structure of the compound; wherein Z is a protein component of the compound, which protein component comprises one or more polypeptides, wherein at least one of the one or more polypeptides comprises consecutive amino acids which (i) are identical to a stretch of consecutive amino acids present in a chain of an Fc domain of an antibody; (ii) bind to an Fc receptor; and (iii) have at their N-terminus a sequence selected from the group consisting of a cysteine or selenocysteine; wherein the dashed line between B and Z represents a peptidyl linkage; and wherein the solid line between A and B represents a nonpeptidyl linkage.

  本发明提供了含有三嗪或反式环辛烯基团的中间体化合物，可用于制备具有以下结构的化合物： A-B-----Z 其中，A 是化合物的生物活性结构；Z 是化合物的蛋白质成分，该蛋白质成分包括一个或多个多肽，其中一个或多个多肽中至少有一个多肽包括连续氨基酸，这些连续氨基酸(i) 与抗体 Fc 结构域链中存在的一段连续氨基酸相同；(ii)与 Fc 受体结合；以及(iii)在其 N 端具有选自半胱氨酸或硒半胱氨酸组成的组的序列；其中 B 和 Z 之间的虚线代表肽基连接；而 A 和 B 之间的实线代表非肽基连接。
• Hybrid immunoglobulin containing non-peptidyl linkage
  申请人：Biomolecular Holdings LLC

  公开号：US11066459B2

  公开（公告）日：2021-07-20

  The present invention provides a compound having the structure: A-B - - - Z wherein A is a biologically active structure of the compound; wherein Z is a protein component of the compound, which protein component comprises one or more polypeptides, wherein at least one of the one or more polypeptides comprises consecutive amino acids which (i) are identical to a stretch of consecutive amino acids present in a chain of an Fc domain of an antibody; (ii) bind to an Fc receptor; and (iii) have at their N-terminus a sequence selected from the group consisting of a cysteine or selenocysteine; wherein the dashed line between B and Z represents a peptidyl linkage; and wherein the solid line between A and B represents a nonpeptidyl linkage, as well as intermediates dimers thereof, and processes of producing the compounds of the invention.

  本发明提供了一种具有以下结构的化合物： A-B - - Z 其中 A 是该化合物的生物活性结构；其中 Z 是该化合物的蛋白质组分，该蛋白质组分包括一个或多个多肽，其中一个或多个多肽中的至少一个多肽包括连续氨基酸，这些连续氨基酸(i) 与抗体的 Fc 结构域链中存在的一段连续氨基酸相同；(ii)与 Fc 受体结合；(iii)在其 N 端具有选自由半胱氨酸或硒半胱氨酸组成的组的序列；其中 B 和 Z 之间的虚线表示肽基连接；A 和 B 之间的实线表示非肽基连接，以及其中间体二聚体，以及生产本发明化合物的工艺。
• Multidrug multiligand conjugates for targeted drug delivery
  申请人：——

  公开号：US20030082192A1

  公开（公告）日：2003-05-01

  Described is a multi drug multiligand conjugate for targeted drug delivery. The MDML conjugate contains a plurality of tripartite molecules linked to a central scaffold moiety, with each tripartite molecule comprising a targeting molecule, a therapeutic agent and a scaffold binding element. The MDML conjugate allows for more efficient delivery of therapeutic agents to the cells resulting in enhanced therapeutic efficiency. A model MDL conjugate is disclosed as well as method for the synthesis of the model conjugate.

  所述的是一种用于靶向给药的多药物多配体共轭物。MDML 共轭物包含多个与中心支架分子相连的三方分子，每个三方分子包括靶向分子、治疗剂和支架结合元件。MDML 共轭物能更有效地将治疗剂输送到细胞，从而提高治疗效率。本文公开了一种 MDL 结合物模型以及合成该结合物模型的方法。
• HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE
  申请人：Capon, Daniel J.

  公开号：EP2968495B1

  公开（公告）日：2019-07-03
• MULTIDRUG MULTILIGAND CONJUGATES FOR TARGETED DRUG DELIVERY
  申请人：Safavy Ahmad

  公开号：US20080167370A1

  公开（公告）日：2008-07-10

  Described is a multi drug multiligand conjugate for targeted drug delivery. The MDML conjugate contains a plurality of tripartite molecules linked to a central scaffold moiety, with each tripartite molecule comprising a targeting molecule, a therapeutic agent and a scaffold binding element. The MDML conjugate allows for more efficient delivery of therapeutic agents to the cells resulting in enhanced therapeutic efficiency. A model MDL conjugate is disclosed as well as method for the synthesis of the model conjugate.