3-amino-5-(9H-fluoren-9-ylmethoxycarbonylamino)benzoic acid | 212118-78-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 3-amino-5-(9H-fluoren-9-ylmethoxycarbonylamino)benzoic acid
• 英文别名: 3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-aminobenzoic acid
• CAS: 212118-78-0
• 化学式: C₂₂H₁₈N₂O₄
• 分子量: 374.396
• InChiKey: ZXZLIDHPHFIAIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  102
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  二碳酸二叔丁酯 、 3-amino-5-(9H-fluoren-9-ylmethoxycarbonylamino)benzoic acid 在 N,N-二异丙基乙胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 4.0h， 以51%的产率得到BOC-3-氨基-5-(FMOC-氨基)苯甲酸
  参考文献：
  名称：

  Microwave-Assisted Synthesis of Aryl Amide Bonds on Solid Phase

  摘要：

  A novel microwave-assisted synthesis of a library of triarylamides has been undertaken on the solid-phase.

  DOI：

  10.1080/00397910903370618
• 作为产物：
  描述：

  3-nitro-5-(9H-fluoren-9-ylmethoxycarbonylamino)benzoic acid 在 tin(II) chloride dihdyrate 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以81%的产率得到3-amino-5-(9H-fluoren-9-ylmethoxycarbonylamino)benzoic acid
  参考文献：
  名称：

  Microwave-Assisted Synthesis of Aryl Amide Bonds on Solid Phase

  摘要：

  A novel microwave-assisted synthesis of a library of triarylamides has been undertaken on the solid-phase.

  DOI：

  10.1080/00397910903370618

文献信息

• Combinatorial libraries based on a novel and readily accessible “centroid” scaffold
  作者：Bernard R. Neustadt、Elizabeth M. Smith、Terry Nechuta、Yongzheng Zhang

  DOI：10.1016/s0040-4039(98)01076-4

  日期：1998.7

  A convenient large-scale preparation of the trifunctional acid 1 has been developed. This acid serves as a useful scaffold for construction of combinatorial libraries incorporating three variable elements in a centro-symmetric array. (C) 1998 Elsevier Science Ltd. All rights reserved.
• EP1446163A4
  申请人：——

  公开号：EP1446163A4

  公开（公告）日：2006-01-04
• MULTIDRUG MULTILIGAND CONJUGATES FOR TARGETED DRUG DELIVERY
  申请人：THE UAB RESEARCH FOUNDATION

  公开号：EP1446163A2

  公开（公告）日：2004-08-18
• [EN] MULTIDRUG MULTILIGAND CONJUGATES FOR TARGETED DRUG DELIVERY<br/>[FR] CONJUGUES MULTIMEDICAMENTS MULTILIGANDS PERMETTANT UNE ADMINISTRATION CIBLEE DE MEDICAMENTS
  申请人：UAB RESEARCH FOUNDATION

  公开号：WO2003035011A2

  公开（公告）日：2003-05-01

  Described is a multi drug multiligand conjugate for targeted drug delivery. The MDML conjugate contains a plurality of tripartite molecules linked to a central scaffold moiety, with each tripartite molecule comprising a targeting molecule, a therapeutic agent and a scaffold binding element. The MDML conjugate allows for more efficient delivery of therapeutic agents to the cells resulting in enhanced therapeutic efficiency. A model MDL conjugate is disclosed as well as method for the synthesis of the model conjugate.
• Microwave-Assisted Synthesis of Aryl Amide Bonds on Solid Phase
  作者：Philip A. Helliwell、Ruth E. Fake、Kevin G. Kerr、Barbara Santry、Austen Speakman、Anne Routledge

  DOI：10.1080/00397910903370618

  日期：2010.9.20

  A novel microwave-assisted synthesis of a library of triarylamides has been undertaken on the solid-phase.