D-核糖醇-5-磷酸 | 35320-17-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: D-核糖醇-5-磷酸
• 英文名称: D-ribitol 5-phosphate
• 英文别名: D-ribitol-5-phosphate；ribitol-5-phosphate；ribitol-5P；L-O¹-phosphono-ribitol；Phosphorsaeure-mono-(L-ribo-2,3,4,5-tetrahydroxy-pentylester)；L-O¹-Phosphono-ribit；[(2R,3S,4S)-2,3,4,5-tetrahydroxypentyl] dihydrogen phosphate
• CAS: 35320-17-3
• 化学式: C₅H₁₃O₈P
• 分子量: 232.127
• InChiKey: VJDOAZKNBQCAGE-LMVFSUKVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  148
• 氢给体数：
  6
• 氢受体数：
  8

安全信息

• 海关编码：
  2919900090

反应信息

• 作为反应物：
  描述：

  D-核糖醇-5-磷酸 在 sodium hydroxide 、 Dowex resin (NH₄(+) form) 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 重水 为溶剂， 反应 2.0h， 以80%的产率得到NH4(+) salt of D-ribitol-4,5-cyclophosphate
  参考文献：
  名称：

  Structural studies and chemistry of bacterial capsular polysaccharides. Investigations of phosphodiester-linked capsular polysaccharides isolated from Haemophilus influenzae types a, b, c, and f: NMR spectroscopic identification and chemical modification of end groups and the nature of base-catalyzed hydrolytic depolymerization

  摘要：

  DOI：

  10.1021/ja00374a033
• 作为产物：
  描述：

  (2,3,4-三羟基-5-氧代戊基)磷酸二氢酯 在 硼酸三钠 、 水 作用下， 生成 D-核糖醇-5-磷酸
  参考文献：
  名称：

  Baddiley et al., Journal of the Chemical Society, 1956, p. 4583,4588

  摘要：

  DOI：

文献信息

• Isoprenoid biosynthesis
  申请人：——

  公开号：US07122331B1

  公开（公告）日：2006-10-17

  The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More specifically, the present invention relates to screening methods for detecting such inhibitors, and to enzymatically active proteins for performing said methods as well as purified isolated DNA coding for such proteins. Moreover, the present invention relates to novel inhibitors detectable by said screening methods as well as compositions and processes for inhibiting the synthesis of isoprenoids and for controlling the growth of organisms based on said inhibiors. The invention relates also to the development of inhibitor-resistant plant enzymes and plants, plant tissues, plant seeds and plant cells.

  本发明涉及参与异戊二烯生物合成的酶活性，以及用于异戊二烯生物合成酶的抑制剂，尤其是除草剂。更具体地，本发明涉及用于检测此类抑制剂的筛选方法，以及用于执行该方法的酶活性蛋白质和编码该类蛋白质的纯化分离DNA。此外，本发明还涉及通过上述筛选方法检测到的新型抑制剂，以及用于抑制异戊二烯合成和基于该类抑制剂控制生物生长的组合物和过程。本发明还涉及开发抑制剂耐受植物酶和植物、植物组织、植物种子和植物细胞。
• Synthesis of arabinitol 1-phosphate and its use for characterization of arabinitol–phosphate dehydrogenase
  作者：Nikolai V. Soroka、Anna A. Kulminskaya、Elena V. Eneyskaya、Konstantin A. Shabalin、Andrei V. Uffimtcev、Mira Povelainen、Andrei N. Miasnikov、Kirill N. Neustroev

  DOI：10.1016/j.carres.2004.11.030

  日期：2005.3

  D-Arabinitol 1-phosphate (Ara-oll-P), a substrate for D-arabinitol-phosphate dehydrogenase (APDH), was chemically synthesized from D-arabinonic acid in five steps (O-acetylation, chlorination, reduction, phosphorylation, and de-O-acetylation). Ara-oll-P was used as a substrate for the characterization of APDH from Bacillus halodurans. APDH converts Ara-oll-P to xylulose 5-phosphate in the oxidative reaction; both NAD(+) and NADP(+) were accepted as co-factors. Kinetic parameters for the oxidative and reductive reactions are consistent with a ternary complex mechanism. (c) 2004 Elsevier Ltd. All rights reserved.
• Baddiley et al., Journal of the Chemical Society, 1957, p. 4058,4062
  作者：Baddiley et al.

  DOI：——

  日期：——
• Levene; Harris; Stiller, Journal of Biological Chemistry, 1934, vol. 105, p. 154
  作者：Levene、Harris、Stiller

  DOI：——

  日期：——