9-Benzylamino-1,4-methano-1,2,3,4-tetrahydroacridine | 164347-19-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-Benzylamino-1,4-methano-1,2,3,4-tetrahydroacridine
• 英文别名: N-benzyl-3-azatetracyclo[10.2.1.02,11.04,9]pentadeca-2,4,6,8,10-pentaen-10-amine
• CAS: 164347-19-7
• 化学式: C₂₁H₂₀N₂
• 分子量: 300.403
• InChiKey: NSAHZTLHPJYIMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吗啉 、 1,4-Methano-N-(phenylmethylene)-1,2,3,4-tetrahydro-9-acridinamine 、 1,4-Methano-1,2,3,4-tetrahydro-9-acridinamine 在 sodium hydroxide 、 NaCNBH3 、 苯甲醛 作用下， 以 溶剂黄146 、 甲苯 为溶剂， 生成 9-Benzylamino-1,4-methano-1,2,3,4-tetrahydroacridine
  参考文献：
  名称：

  9-amino-1,4ethano-1,2,3,4-tetrahydroacridine and related compounds

  摘要：

  已披露的化合物具有以下结构式##STR1##其中R为氢、较低烷基或较低烷基羰基；R.sub.1为氢、较低烷基、较低烷基羰基、芳基、二较低烷基氨基较低烷基、芳基较低烷基、二芳基较低烷基、氧桥芳基较低烷基或氧桥二芳基较低烷基；R.sub.2和R.sub.3独立地为H或CH.sub.3；X为氢、较低烷基、环烷基、较低烷氧基、卤素、羟基、硝基、三氟甲基、甲酰基、较低烷基羰基、芳基羰基、--SH、较低烷基硫基、--NHCOR.sub.4或--NR.sub.5 R.sub.6，其中R.sub.4为氢或较低烷基，R.sub.5和R.sub.6独立地为氢、较低烷基或环烷基；Y和Z独立地为直接键、CR.sub.7 R.sub.8或CR.sub.7 R.sub.8--CR.sub.9 R.sub.10；L和Q独立地为CR'.sub.7 R'.sub.8、CR'.sub.7 R'.sub.8--CR'.sub.9 R'.sub.10、CR'.sub.7.dbd.CR'.sub.9或CR'.sub.7 R'.sub.8--CR'.sub.9 R'.sub.10--CR.sub.11 R.sub.12，其中R.sub.7至R.sub.12和R'.sub.7至R'.sub.10中的每个独立地为H或CH.sub.3；其立体、光学和几何异构体，以及其药学上可接受的酸盐，用于增强记忆。

  公开号：

  US05401749A1

文献信息

• 9-Amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds, intermediates and a process for the preparation thereof and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0278499A2

  公开（公告）日：1988-08-17

  There are disclosed compounds having the formula wherein R is hydrogen, loweralkyl or loweralkylcarbonyl; R₁ is hydrogen, loweralkyl, loweralkylcarbonyl, aryl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, oxygen-bridged arylloweralkyl or oxygen-bridged diarylloweralkyl; R₂ and R₃ are independently H or CH₃; X is hydrogen, loweralkyl, cycloalkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, formyl, loweralkylcarbonyl, arylcarbonyl, -SH, loweralkylthio, -NHCOR₄ or -NR₅R₆ where R₄ is hydrogen or loweralkyl, and R₅ and R₆ are independently hydrogen, loweralkyl or cycloalkyl; Y and Z are independently a direct bond, CR₇R₈ or CR₇R₈-CR₉R₁₀; and P and Q are independently CR₇ʹR₈ʹ, CR₇ʹR₈ʹ-CR₉ʹR₁₀ʹ or CR₇ʹR₈ʹ-CR₉ʹR₁₀ʹ-CR₁₁R₁₂, where each of R₇ through R₁₂ and R₇ʹ through R₁₀ʹ is independently H or CH₃; stereo, optical and geometrical isomers thereof, and pharmaceutically acceptable acid addition salts thereof, which are useful for enhancing memory.

  所公开的化合物具有以下式子 其中 R 是氢、低级烷基或低级烷基羰基；R₁ 是氢、低级烷基、低级烷基羰基、芳基、稀释烷基氨基低级烷基、芳基低级烷基、二芳基低级烷基、氧桥接芳基低级烷基或氧桥接二芳基低级烷基；R₂ 和 R₃ 独立地是 H 或 CH₃；X 是氢、低级烷基、环烷基、低级烷氧基、卤素、羟基、硝基、三氟甲基、甲酰基、低级烷基羰基、芳基羰基、-SH、低级烷硫基、-NHCOR₄或 -NR₅R₆，其中 R₄ 是氢或低级烷基，R₅ 和 R₆ 独立地是氢、低级烷基或环烷基；Y 和 Z 独立地为直接键、CR₇R₈ 或 CR₇R₈-CR𠢙R₁₀ ；P和Q独立地为CR₇ʹR₈ʹ，CR₇ʹR₈ʹ-CR₉ʹR₁₀ʹ或CR₇ʹR₈ʹ-CR₉ʹR₁₀ʹ-CR₁₁R₁₂，其中R₇至R₁₂和R₇ʹ至R₁₀ʹ各自独立地为H或CH₃；立体异构体、光学异构体和几何异构体及其药学上可接受的酸加成盐，可用于增强记忆力。
• US4897400A
  申请人：——

  公开号：US4897400A

  公开（公告）日：1990-01-30
• US5401749A
  申请人：——

  公开号：US5401749A

  公开（公告）日：1995-03-28
• 9-amino-1,4ethano-1,2,3,4-tetrahydroacridine and related compounds
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US05401749A1

  公开（公告）日：1995-03-28

  There are disclosed compounds having the formula ##STR1## wherein R is hydrogen, loweralkyl or loweralkylcarbonyl; R.sub.1 is hydrogen, loweralkyl, loweralkylcarbonyl, aryl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, oxygen-bridged arylloweralkyl or oxygen-bridged diarylloweralkyl; R.sub.2 and R.sub.3 are independently H or CH.sub.3 ; X is hydrogen, loweralkyl, cycloalkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, formyl, loweralkylcarbonyl, arylcarbonyl, --SH, loweralkylthio, --NHCOR.sub.4 or --NR.sub.5 R.sub.6 where R.sub.4 is hydrogen or loweralkyl, and R.sub.5 and R.sub.6 are independently hydrogen, loweralkyl or cycloalkyl; Y and Z are independently a direct bond, CR.sub.7 R.sub.8 or CR.sub.7 R.sub.8 --CR.sub.9 R.sub.10 ; and L and Q are independently CR'.sub.7 R'.sub.8, CR'.sub.7 R'.sub.8 --CR'.sub.9 R'.sub.10, CR'.sub.7 .dbd.CR'.sub.9 or CR'.sub.7 R'.sub.8 --CR'.sub.9 R'.sub.10 --CR.sub.11 R.sub.12, where each of R.sub.7 through R.sub.12 and R'.sub.7 through R'.sub.10 is independently H or CH.sub.3 ; a stereo, optical and geometrical isomers thereof, and pharmaceutically acceptable acid addition salts thereof, which are useful for enhancing memory.

  已披露的化合物具有以下结构式##STR1##其中R为氢、较低烷基或较低烷基羰基；R.sub.1为氢、较低烷基、较低烷基羰基、芳基、二较低烷基氨基较低烷基、芳基较低烷基、二芳基较低烷基、氧桥芳基较低烷基或氧桥二芳基较低烷基；R.sub.2和R.sub.3独立地为H或CH.sub.3；X为氢、较低烷基、环烷基、较低烷氧基、卤素、羟基、硝基、三氟甲基、甲酰基、较低烷基羰基、芳基羰基、--SH、较低烷基硫基、--NHCOR.sub.4或--NR.sub.5 R.sub.6，其中R.sub.4为氢或较低烷基，R.sub.5和R.sub.6独立地为氢、较低烷基或环烷基；Y和Z独立地为直接键、CR.sub.7 R.sub.8或CR.sub.7 R.sub.8--CR.sub.9 R.sub.10；L和Q独立地为CR'.sub.7 R'.sub.8、CR'.sub.7 R'.sub.8--CR'.sub.9 R'.sub.10、CR'.sub.7.dbd.CR'.sub.9或CR'.sub.7 R'.sub.8--CR'.sub.9 R'.sub.10--CR.sub.11 R.sub.12，其中R.sub.7至R.sub.12和R'.sub.7至R'.sub.10中的每个独立地为H或CH.sub.3；其立体、光学和几何异构体，以及其药学上可接受的酸盐，用于增强记忆。