2-bicyclo[2.2.1]heptanyl formate | 90199-27-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-bicyclo[2.2.1]heptanyl formate
• CAS: 90199-27-2
• 化学式: C₈H₁₂O₂
• mdl: MFCD00066690
• 分子量: 140.182
• InChiKey: SGXIEZNAOCVSKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-bicyclo[2.2.1]heptanyl formate 在 水 、 sodium hydroxide 作用下， 生成 双环[2.2.1]-2-庚醇
  参考文献：
  名称：

  [EN] CHEMICAL PROCESS
  [FR] PROCÉDÉ CHIMIQUE

  摘要：

  The present invention provides, inter alia, a process for preparing a compound of formula (I) wherein the substituents are as defined in claim 1.

  公开号：

  WO2023213926A1
• 作为产物：
  描述：

  降冰片烯 、 甲酸 以83 %的产率得到2-bicyclo[2.2.1]heptanyl formate
  参考文献：
  名称：

  [EN] CHEMICAL PROCESS
  [FR] PROCÉDÉ CHIMIQUE

  摘要：

  The present invention provides, inter alia, a process for preparing a compound of formula (I) wherein the substituents are as defined in claim 1.

  公开号：

  WO2023213926A1

文献信息

• Conversion of Alkyl Halides into Alcohols via Formyloxylation Reaction with DMF Catalyzed by Silver Salts
  作者：Antonio Abad、Consuelo Agulló、Ana C. Cuñat、Ismael Navarro

  DOI：10.1055/s-2005-918453

  日期：——

  transformation of alkyl halides into alcohols via a two-step process based on the reaction with DMF catalyzed by Ag(I) salts followed by acid or basic hydrolysis of the intermediate formate ester has been evaluated. The results show that a large variety of primary and some secondary alkyl halides can be transformed efficiently into the corresponding alcohols, making this alkyl halide to alcohol interconversion

  已经评估了通过两步法将卤代烷转化为醇，该方法基于与 DMF 的反应，由 Ag(I) 盐催化，然后是中间体甲酸酯的酸或碱水解。结果表明，多种伯和一些仲卤代烷可以有效地转化为相应的醇，使这种卤代烷到醇的相互转化成为现有程序的有价值的替代品，特别是在具有不稳定官能团的分子中，这些分子通常参与多步合成。
• Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
  申请人：Henriksson Martin

  公开号：US20060142357A1

  公开（公告）日：2006-06-29

  The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

  本发明涉及具有式（I），（II），（III）或（IV）的化合物：其中R1，R2，R3，R4，R5，R6，R7，X和Z如本文所定义，并且还涉及包含该化合物的制药组合物，以及使用该化合物治疗与人类11-β-羟基类固醇脱氢酶1型酶相关的疾病和制备作用于人类11-β-羟基类固醇脱氢酶1型酶的药物的方法。
• Inhibitors of 11-Beta-Hydroxy Steroid Dehydrogenase Type 1
  申请人：Henriksson Martin

  公开号：US20070281938A1

  公开（公告）日：2007-12-06

  The present invention relates to compounds with the formula (I) wherein R 1 , R 2 , R 3 , R 4 , and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

  本发明涉及化合物式（I），其中R1、R2、R3、R4和Z的定义如本文所述，以及包含该化合物的制药组合物，以及该化合物在医学上的使用和用于制备对人类11-β-羟基类固醇脱氢酶1型酶起作用的药物。
• INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1
  申请人：Henriksson Martin

  公开号：US20110082107A1

  公开（公告）日：2011-04-07

  The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

  本发明涉及具有式（I），（II），（III）或（IV）的化合物：其中R1，R2，R3，R4，R5，R6，R7，X和Z如本文所定义，并且还涉及包含这些化合物的制药组合物，以及使用这些化合物治疗与人类11-β-羟基类固醇脱氢酶1型酶相关的疾病的方法，以及用于制备对人类11-β-羟基类固醇脱氢酶1型酶起作用的药物的方法。
• Homologation of carbonyloxy containing compounds and catalyst therefor
  申请人：UNION CARBIDE CORPORATION

  公开号：EP0064287A1

  公开（公告）日：1982-11-10

  This invention produces higher homologs, i.e., differing by at least a -CH2- unit, of carbonyloxy-containing compounds by treating the carbonyloxy-containing compounds with carbon monoxide and hydrogen in the presence of a ruthenium-containing compound, a proton donor, an iodide promoter, and optionally, a manganese-containing compound.

  本发明通过在含钌化合物、质子供体、碘化促进剂和可选的含锰化合物的存在下，用一氧化碳和氢气处理含碳酰氧基化合物，制备含碳酰氧基化合物的高级同系物，即至少有一个-CH2-单元不同的同系物。