eudeshonokiol B | 133056-10-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: eudeshonokiol B
• 英文别名: 4-[2-[[(1R,4aR,7R,8aR)-7-(2-hydroxypropan-2-yl)-1,4a-dimethyl-2,3,4,5,6,7,8,8a-octahydronaphthalen-1-yl]oxy]-5-prop-2-enylphenyl]-2-prop-2-enylphenol
• CAS: 133056-10-7
• 化学式: C₃₃H₄₄O₃
• 分子量: 488.711
• InChiKey: NGAOCYWZXSGXOS-GMWCSNPESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  eudeshonokiol B 在 三氟乙酸 作用下， 以 乙醚 、 苯 为溶剂， 反应 46.0h， 生成 4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇
  参考文献：
  名称：

  Neurotrophic sesquiterpene-neolignans from magnolia obovata: structure and neurotrophic activity

  摘要：

  Novel sesquiterpene-neolignans, audesobovatols A (1) and B (2) cudesmagnolol (3), eudeshonokiols A (4) and B (5), clovanemagnolol (6), and caryolanemagnolol (7), have been isolated from the bark of Magnolia obovata. Their structures were elucidated to be sesquiterpenes (eudesmol, 4,4,8-trimethyltricyclo [6.3.1.0(2,5)] dodecane-1,9-diol, and clovanediol) combined through ether bond with neolignans such as obovatol, honokiol, and magnolol on the basis of spectral data, degradation, and/or synthesis. Compounds I, 6, and 7 were found to exhibit interesting neurotrophic activity on a neuronal cell culture system derived from fetal rat hemisphere.

  DOI：

  10.1016/s0040-4020(01)89002-5

文献信息

• COMPOSITIONS COMPRISING EXTRACTS OF APLINIA AND OTHER PLANTS FOR IMPROVING JOINT HEALTH AND TREATING ARTHRITIS
  申请人：Unigen, Inc.

  公开号：EP4100034A1

  公开（公告）日：2022-12-14
• Compositions and Methods for Regulating Homeostasis of Chondrocytes, Extracellular Matrix, Articular Cartilage, and Phenotype of Arthritis
  申请人：Unigen, Inc.

  公开号：US20220000964A1

  公开（公告）日：2022-01-06

  Medicinal plant extracts and their bioactives from Alpinia, Magnolia, Kochia and Piper /Pepper are disclosed herein in combination or alone in regulating homeostasis of chondrocytes, extracellular matrix, articular cartilage, and phenotype of arthritis that lead to enhanced anabolic functions of chondrocytes, increased renewal/rebuilding/regeneration of extracellular matrix and articular cartilage, and improved phenotype of osteoarthritis and rheumatoid arthritis.
• [EN] COMPOSITIONS COMPRISING EXTRACTS OF APLINIA AND OTHER PLANTS FOR IMPROVING JOINT HEALTH AND TREATING ARTHRITIS<br/>[FR] COMPOSITIONS COMPRENANT DES EXTRAITS D'APLINIA ET D'AUTRES PLANTES POUR AMÉLIORER LA SANTÉ ARTICULAIRE ET TRAITER L'ARTHRITE
  申请人：UNIGEN INC

  公开号：WO2021159042A1

  公开（公告）日：2021-08-12

  Medicinal plant extracts and their bioactives from Alpinia, Magnolia, Kochia and Piper/Pepper are disclosed herein in combination or alone in regulating homeostasis of chondrocytes, extracellular matrix, articular cartilage, and phenotype of arthritis that lead to enhanced anabolic functions of chondrocytes, increased renewal/rebuilding/regeneration of extracellular matrix and articular cartilage, and improved phenotype of osteoarthritis and rheumatoid arthritis.
• Neurotrophic sesquiterpene-neolignans from magnolia obovata: structure and neurotrophic activity
  作者：Yoshiyasu Fukuyama、Yukio Otoshi、Kumi Miyoshi、Kazuhiko Nakamura、Mitsuaki Kodama、Masakazu Nagasawa、Takashi Hasegawa、Hiroshi Okazaki、Michiharu Sugawara

  DOI：10.1016/s0040-4020(01)89002-5

  日期：——

  Novel sesquiterpene-neolignans, audesobovatols A (1) and B (2) cudesmagnolol (3), eudeshonokiols A (4) and B (5), clovanemagnolol (6), and caryolanemagnolol (7), have been isolated from the bark of Magnolia obovata. Their structures were elucidated to be sesquiterpenes (eudesmol, 4,4,8-trimethyltricyclo [6.3.1.0(2,5)] dodecane-1,9-diol, and clovanediol) combined through ether bond with neolignans such as obovatol, honokiol, and magnolol on the basis of spectral data, degradation, and/or synthesis. Compounds I, 6, and 7 were found to exhibit interesting neurotrophic activity on a neuronal cell culture system derived from fetal rat hemisphere.