N-(2-(1H-吲哚-3-基)乙基)-N-异丙烷-2-胺 | 14780-24-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: N-(2-(1H-吲哚-3-基)乙基)-N-异丙烷-2-胺
• 英文名称: (-)-DIPT
• 英文别名: diisopropyltryptamine；N,N-Diisopropyltryptamine；N-[2-(1H-indol-3-yl)ethyl]-N-propan-2-ylpropan-2-amine
• CAS: 14780-24-6
• 化学式: C₁₆H₂₄N₂
• 分子量: 244.38
• InChiKey: ZRVAAGAZUWXRIP-UHFFFAOYSA-N

物化性质

• 沸点：
  376.4±25.0 °C(Predicted)
• 密度：
  1.010±0.06 g/cm3(Predicted)
• 溶解度：
  DMF：10mg/mL； DMSO：14mg/mL； DMSO:PBS(pH7.2)(1:1)：0.3mg/ml；乙醇：5mg/mL；甲醇：1mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  19
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2933990090

制备方法与用途

用途
DiPT 是一种全球被滥用的致幻类迷幻药。它非正式地被称为“oxy”，能强烈抑制多巴胺、血清素和去甲肾上腺素的再摄取。DiPT 是一种与 5-MeO-DiPT 相关但不常见的致幻药物。本产品仅用于法医和研究应用。

反应信息

• 作为试剂：
  描述：

  (4S,5R)-4-(Dimethylphenylsilyl)-5-[(phenylmethoxy)methyl]-1-cyclopentene-1-methanol 、 叔丁基过氧化氢 在 titanium(IV) isopropylate 、 N-(2-(1H-吲哚-3-基)乙基)-N-异丙烷-2-胺 1-L 、 氩 、 peroxide 、 sodium hydrogensulfite 、 碳酸氢钠 、 solution 、 Brine 作用下， 以 二氯甲烷 为溶剂， 反应 5.83h， 以to give the crude title compound (60 g, >100% material balance) as an oil的产率得到3-(Dimethylphenylsilyl)-2-((phenylmethoxy)methyl]-6-oxabicyclo[3.1.0]hexane-1-methanol
  参考文献：
  名称：

  Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta )]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one

  摘要：

  本发明揭示了制备抗病毒药物恩替卡韦的工艺。还揭示了用于分离和纯化恩替卡韦的树脂吸附工艺。还揭示了制备恩替卡韦有用的各种中间体。

  公开号：

  US07034152B2

文献信息

• METHOD FOR PREPARING FUROFURAN LIGNAN COMPOUND
  申请人：Cho Si Young

  公开号：US20150073158A1

  公开（公告）日：2015-03-12

  The present invention relates to a method for preparing a furofuran lignan compound, comprising a step of selecting and alkylating an epoxy alcohol compound and an optical isomer thereof. (+)-furofuran lignan and (−)-furofuran lignan, as well as an optical isomer thereof, can be selectively prepared by means of the method.

  本发明涉及一种用于制备呋喃木质素化合物的方法，包括选择和烷基化环氧醇化合物及其光学异构体的步骤。通过该方法可以选择性地制备（+）-呋喃木质素和（-）-呋喃木质素，以及它们的光学异构体。
• [EN] METHODS OF TREATING PSYCHOLOGICAL CONDITIONS<br/>[FR] PROCÉDÉS DE TRAITEMENT DE TROUBLES PSYCHOLOGIQUES
  申请人：UNIV OKLAHOMA STATE

  公开号：WO2010151258A1

  公开（公告）日：2010-12-29

  A method and composition for inducing in a subject a tolerance to a psychoactive substance or for treating an abnormal mental condition in a subject. The composition used in the method comprises in one embodiment a 5-HT2B receptor agonist disposed within a pharmaceutically-acceptable vehicle or carrier.

  一种用于诱导受试者对精神活性物质产生耐受性或用于治疗受试者异常精神状况的方法和组合物。该方法中使用的组合物在一个实施例中包括一个5-HT2B受体激动剂，该激动剂被置于药学上可接受的载体或载体中。
• TRYPTAMINE PRODRUGS
  申请人：Field Trip Psychedelics Inc.

  公开号：US20210403425A1

  公开（公告）日：2021-12-30

  The present invention provides a tryptamine prodrug compound. A compound represented by the formula (I) where each symbol is as described in the specification, or a salt or zwitterion thereof, is converted to an active which has 5HT2A receptor agonist activity, and is useful as an agent for the treatment of depression.

  本发明提供了一种色胺前药化合物。化合物由公式(I)表示，其中每个符号如说明书中所述，或其盐或离子，被转化为具有5HT2A受体激动剂活性的活性物质，并用作抗抑郁剂的药物。
• COMPOSITION FOR PREVENTING OR TREATING HEART DISEASE
  申请人：AMOREPACIFIC CORPORATION

  公开号：US20150283110A1

  公开（公告）日：2015-10-08

  The present invention relates to a composition for preventing or treating heart disease, and more particularly, to a composition for preventing or treating heart disease, comprising (+)-syringaresinol. Specifically, (+)-syringaresinol as an active ingredient may exhibit excellent effect of preventing or improving heart disease by promoting SIRT1 expression and suppressing death of cardiomyocytes induced by reactive oxygen species. Accordingly, the composition according to the present disclosure may be used to prevent, improve or treat heart diseases including cardiovascular diseases.

  本发明涉及一种用于预防或治疗心脏疾病的组合物，更具体地，涉及一种包含(+)-丁香酚的预防或治疗心脏疾病的组合物。具体而言，(+)-丁香酚作为活性成分，可以通过促进SIRT1表达和抑制由活性氧引起的心肌细胞死亡，展现出预防或改善心脏疾病的卓越效果。因此，根据本公开的组合物可用于预防、改善或治疗包括心血管疾病在内的心脏疾病。
• PESTICIDAL COMPOSITION COMPRISING INDOLE DERIVATES
  申请人：Bednarek Pawel

  公开号：US20090028796A1

  公开（公告）日：2009-01-29

  The present invention is directed to pesticidal compositions comprising indole derivatives. These indole derivatives are especially active against phytopathogenic fungi. Furthermore, the invention relates to the use of indole derivatives for the production of pesticides and the use of the compositions according to the invention as pesticides. The present invention is also directed to a process for producing a pesticidal composition and to pesticidal compositions prepared by this process. In addition, the invention relates to a process for preventing or combating pests and to a process for protecting plants against pests, especially against phytopathogenic fungi. Further, the invention is directed to plants or seeds as well as objects or materials which have been protected against pests by treatment with a composition according to the invention. Further, the invention is directed to a method for identifying a substance having pesticidal activity. Further, the invention is directed to a method of identifying the mode of action of and/or of providing binding proteins for a pesticidal compound of the present invention. Finally, the invention is directed to a method for diagnosing pest infection of a plant and to the use of a pesticidal compound of the present invention as diagnostic markers.

  本发明涉及包含吲哚衍生物的杀虫组合物。这些吲哚衍生物特别对植物病原真菌具有活性。此外，本发明涉及使用吲哚衍生物制备杀虫剂以及使用本发明中的组合物作为杀虫剂。本发明还涉及制备杀虫组合物的过程以及通过该过程制备的杀虫组合物。此外，本发明还涉及预防或对抗害虫的过程以及保护植物免受害虫，特别是植物病原真菌的过程。此外，本发明还涉及经过本发明中的组合物处理后受到保护的植物或种子以及物体或材料。本发明还涉及识别具有杀虫活性的物质的方法。此外，本发明还涉及识别本发明中杀虫化合物的作用方式和/或提供结合蛋白的方法。最后，本发明涉及诊断植物害虫感染的方法以及使用本发明中的杀虫化合物作为诊断标记的方法。