(1R,2S)-3,3-Dimethoxy-cyclobutane-1,2-dicarboxylic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester | 139012-63-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1R,2S)-3,3-Dimethoxy-cyclobutane-1,2-dicarboxylic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester
• 英文别名: Bis[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl] (1R,2S)-3,3-dimethoxycyclobutane-1,2-dicarboxylate；bis[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] (1R,2S)-3,3-dimethoxycyclobutane-1,2-dicarboxylate
• CAS: 139012-63-8
• 化学式: C₂₈H₄₈O₆
• 分子量: 480.686
• InChiKey: DGWBEODODXRBHL-OBLMWKTISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,1-二甲氧基乙烯 、 di-L-menthyl fumarate 生成 (1S,2R)-3,3-Dimethoxy-cyclobutane-1,2-dicarboxylic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester 、 (1R,2S)-3,3-Dimethoxy-cyclobutane-1,2-dicarboxylic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester
  参考文献：
  名称：

  An efficient and diastereoselective [2+2] cycloaddition: convenient and enantioselective route to trans-2′,3′-dihydroxymethylcyclobutane nucleoside analogs

  摘要：

  An efficient route to (2S-trans)-2,3-bis[(benzoyloxy)methyl]cyclobutanone (3a), a key intermediate in the synthesis of cyclobutane nucleoside analogs, via a novel asymmetric [2 + 2] cycloaddition, is described.

  DOI：

  10.1016/0040-4039(91)85023-x

文献信息

• An efficient and diastereoselective [2+2] cycloaddition: convenient and enantioselective route to trans-2′,3′-dihydroxymethylcyclobutane nucleoside analogs
  作者：Saleem Ahmad

  DOI：10.1016/0040-4039(91)85023-x

  日期：1991.11

  An efficient route to (2S-trans)-2,3-bis[(benzoyloxy)methyl]cyclobutanone (3a), a key intermediate in the synthesis of cyclobutane nucleoside analogs, via a novel asymmetric [2 + 2] cycloaddition, is described.