3-(2-norbornyl)amino-1-propanesulfonic acid | 720699-40-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3-(2-norbornyl)amino-1-propanesulfonic acid
• 英文别名: 3-(2-Bicyclo[2.2.1]heptanylamino)propane-1-sulfonic acid
• CAS: 720699-40-1
• 化学式: C₁₀H₁₉NO₃S
• 分子量: 233.332
• InChiKey: BGZJQENTTIDTBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,3-丙烷磺内酯 、 双环[2.2.1]-2-庚胺 以 丁酮 为溶剂， 反应 1.0h， 以53%的产率得到3-(2-norbornyl)amino-1-propanesulfonic acid
  参考文献：
  名称：

  [EN] METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES
  [FR] METHODES ET COMPOSITIONS POUR TRAITER LES MALADIES LIEES A L'AMYLOIDE

  摘要：

  公开号：

  WO2004113275A3

文献信息

• Methods and compositions for treating amyloid-related diseases
  申请人：Kong Xianqi

  公开号：US20050096385A1

  公开（公告）日：2005-05-05

  Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

  本文描述了用于治疗或预防与淀粉样蛋白相关疾病的方法、化合物、药物组合物和试剂盒。
• METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES
  申请人：Kong Xianqi

  公开号：US20100113591A1

  公开（公告）日：2010-05-06

  Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

  本发明涉及用于治疗或预防淀粉样蛋白相关疾病的方法、化合物、制药组合物和试剂盒。
• IONICALLY HYDROPHILIZED POLYISOCYANATES WITH IMPROVED DRYING
  申请人：Covestro Deutschland AG

  公开号：EP3599255A1

  公开（公告）日：2020-01-29

  The invention relates to a polyisocyanate mixture comprising a polyisocyanate component A) having aliphatically and/or cycloaliphatically bonded isocyanate groups and a polyisocyanate component B) having araliphatically and/or aromatically bonded isocyanate groups, characterized in that the polyisocyanate component A) comprises at least 0.85% by weight of sulfonate groups (calculated as SO3; molar weight = 80 g/mol) in chemically bonded form and the proportion of the polyisocyanate component B) is 7 to 43% by weight of the total amount of the components A) and B). The invention further relates to the use thereof and also coating compositions comprising the polyisocyanate mixture and also the substrates coated with these coating compositions.

  本发明涉及一种多异氰酸酯混合物，包括具有脂肪族和/或环脂肪族键合异氰酸酯基团的多异氰酸酯组分 A)和具有芳香族和/或芳香族键合异氰酸酯基团的多异氰酸酯组分 B)，其特征在于多异氰酸酯组分 A)包括至少 0.85%(重量)的磺酸基团(以 SO3 计算；摩尔重量 = 80 g/mol)以化学键形式结合，多异氰酸酯组分 B)的比例为组分 A)和 B)总量的 7%至 43%(重量)。本发明还涉及其用途、包含该多异氰酸酯混合物的涂料组合物以及涂有这些涂料组合物的基材。
• Ionically hydrophilized polyisocyanates, water content
  申请人：Covestro Intellectual Property GmbH & Co. KG

  公开号：US11365277B2

  公开（公告）日：2022-06-21

  The invention relates to a process for producing polyisocyanates containing sulfonate groups, the products obtainable or obtained by said process and also to the use thereof as starting component for producing polyurethane plastics. The invention further relates to coating compositions comprising polyisocyanates containing sulfonate groups and also to the substrates coated with said coating compositions.

  本发明涉及一种生产含磺酸盐基团的多异氰酸酯的工艺、通过所述工艺可获得或得到的产品，以及将其用作生产聚氨酯塑料的起始组分。本发明还涉及包含含磺酸盐基团的多异氰酸酯的涂料组合物，以及用所述涂料组合物涂覆的基材。
• Therapeutic formulations for the treatment of beta-amyloid related diseases
  申请人：Gervais Francine

  公开号：US20060135403A1

  公开（公告）日：2006-06-22

  The method is used for preventing or treating an amyloid-β related disease in a subject. The method comprises administering to a subject in need thereof an effective amount of a first agent that prevents or treats amyloid-β related disease, and a second agent that is (i) a peptide or peptidomimetic that modulates amyloid-β fibril formulation or induces a prophylactic or therapeutic immune response against amyloid-β fibril formulation, or (ii) an immune system modulator that pi-events or inhibits amyloid-β fibril formulation.

  该方法用于预防或治疗受试者的淀粉样蛋白-β相关疾病。 该方法包括向有需要的受试者施用有效量的预防或治疗淀粉样蛋白-β相关疾病的第一种制剂和第二种制剂，第二种制剂是(i)调节淀粉样蛋白-β纤维制剂或诱导针对淀粉样蛋白-β纤维制剂的预防性或治疗性免疫应答的肽或仿肽制剂，或(ii)可诱导或抑制淀粉样蛋白-β纤维制剂的免疫系统调节剂。