1-((1S,7aR)-1,6,6-Trimethyl-2,3,5,6,7,7a-hexahydro-1H-inden-4-yl)-ethanone | 200625-30-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-((1S,7aR)-1,6,6-Trimethyl-2,3,5,6,7,7a-hexahydro-1H-inden-4-yl)-ethanone
• 英文别名: 1-[(1S,7aR)-1,6,6-trimethyl-1,2,3,5,7,7a-hexahydroinden-4-yl]ethanone
• CAS: 200625-30-5
• 化学式: C₁₄H₂₂O
• 分子量: 206.328
• InChiKey: DKVKITJFDLKBRG-JOYOIKCWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  甲基锂 、 1-((1S,7aR)-1,6,6-Trimethyl-2,3,5,6,7,7a-hexahydro-1H-inden-4-yl)-ethanone 以 乙醚 为溶剂， 反应 1.0h， 以80%的产率得到1H-茚-4-甲醇,2,3,5,6,7,7a-六氢-a,a,1,6,6-五甲基-,(1R,7aS)-
  参考文献：
  名称：

  A very short and efficient synthesis of (+)-conocephalenol

  摘要：

  The synthesis of (+)-conocephalenol, a brasilane sesquiterpenoid alcohol, was achieved in seven steps from (R)-pulegone with an overall yield of 15%. The key steps were a radical addition of a tertiary radical to the electrophilic radicophile, (R)-3-methyl-2-methylenecyclopentanone, and an aldol cyclization under acidic conditions. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10391-4
• 作为产物：
  描述：

  5-甲基-5-己烯-2-酮 在 偶氮二异丁腈 、 硫酸 、 氢溴酸 、 三正丁基氢锡 作用下， 以 乙醚 、 溶剂黄146 、 苯 为溶剂， 反应 3.0h， 生成 1-((1S,7aR)-1,6,6-Trimethyl-2,3,5,6,7,7a-hexahydro-1H-inden-4-yl)-ethanone
  参考文献：
  名称：

  A very short and efficient synthesis of (+)-conocephalenol

  摘要：

  The synthesis of (+)-conocephalenol, a brasilane sesquiterpenoid alcohol, was achieved in seven steps from (R)-pulegone with an overall yield of 15%. The key steps were a radical addition of a tertiary radical to the electrophilic radicophile, (R)-3-methyl-2-methylenecyclopentanone, and an aldol cyclization under acidic conditions. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10391-4

文献信息

• TORI, MOTOO;SONO, MASAKAZU;NAKASHIMA, KATSUYUKI;NAKAKI, YOKO;ASAKAWA, YOS+, J. CHEM. SOC. PERKIN TRANS. PT 1,(1991) N, C. 447-450
  作者：TORI, MOTOO、SONO, MASAKAZU、NAKASHIMA, KATSUYUKI、NAKAKI, YOKO、ASAKAWA, YOS+

  DOI：——

  日期：——
• A very short and efficient synthesis of (+)-conocephalenol
  作者：Janine Cossy、Samir BouzBouz、Abdelhak Hakiki

  DOI：10.1016/s0040-4039(97)10391-4

  日期：1997.12

  The synthesis of (+)-conocephalenol, a brasilane sesquiterpenoid alcohol, was achieved in seven steps from (R)-pulegone with an overall yield of 15%. The key steps were a radical addition of a tertiary radical to the electrophilic radicophile, (R)-3-methyl-2-methylenecyclopentanone, and an aldol cyclization under acidic conditions. (C) 1997 Elsevier Science Ltd.