benzo[h]quinoline-4-carboxaldehyde | 855285-41-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: benzo[h]quinoline-4-carboxaldehyde
• 英文别名: benzo[h]quinoline-4-carbaldehyde；Benzo[h]chinolin-4-carbaldehyd；Benzo[h]quinoline-4-carbaldehyde
• CAS: 855285-41-5
• 化学式: C₁₄H₉NO
• 分子量: 207.232
• InChiKey: VOIFQHAXPMJUAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  benzo[h]quinoline-4-carboxaldehyde 在 potassium permanganate 、 丙酮 作用下， 生成 benzo[h]quinoline-4-carboxylic acid
  参考文献：
  名称：

  Derivatives of Benzo (h) quinoline

  摘要：

  DOI：

  10.1021/ja01220a002
• 作为产物：
  描述：

  7,8-苯并喹啉 在 叔丁基过氧化氢 、 ferrous(II) sulfate heptahydrate 、 硫酸 、 三氟乙酸 作用下， 以 乙腈 为溶剂， 反应 17.0h， 生成 benzo[h]quinoline-4-carboxaldehyde
  参考文献：
  名称：

  Synthesis and anti-norovirus activity of pyranobenzopyrone compounds

  摘要：

  During the last decade, noroviruses have gained media attention as the cause of large scale outbreaks of gastroenteritis on cruise ships, dormitories, nursing homes, etc. Although noroviruses do not multiply in food or water, they can cause large outbreaks because approximately 10-100 virions are sufficient to cause illness in a healthy adult. Recently, it was shown that the activity of acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT1) enzyme may be important in norovirus infection. In search of anti-noroviral agents based on the inhibition of ACAT1, we synthesized and evaluated the inhibitory activities of a class of pyranobenzopyrone molecules containing amino, pyridine, substituted quinolines, or 7,8-benzoquinoline nucleus. Three of the sixteen evaluated compounds possess ED50 values in the low micrometer range. 2-Quinolylmethyl derivative 3A and 4-quinolylmethyl derivative 4A showed ED50 values of 3.4 and 2.4 mu M and TD50 values of >200 and 96.4 mu M, respectively. The identified active compounds are suitable for further modification for the development of anti-norovirus agents. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.03.084

文献信息

• PHOSPHORESCENT POLYMER COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME
  申请人：Showa Denko K.K.

  公开号：EP2196517A1

  公开（公告）日：2010-06-16

  Phosphorescent polymer compounds of the invention have high light-emitting efficiency and long luminescent life. Organic electroluminescence devices have the phosphorescent polymer compounds. The phosphorescent polymer compounds include a structural unit that is derived from a compound of Formula (1) below in which L1 and L2 are specific ligands and are selected to satisfy the specific condition.

  本发明的磷光聚合物化合物发光效率高，发光寿命长。有机电致发光器件具有这种磷光聚合物化合物。 磷光聚合物化合物包括一个结构单元，该结构单元由下式（1）化合物衍生而来，其中 L1 和 L2 为特定配体，并根据特定条件进行选择。
• PHOSPHORESCENT POLYMER COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME
  申请人：Showa Denko K.K.

  公开号：EP2196517B1

  公开（公告）日：2012-07-25
• US8426038B2
  申请人：——

  公开号：US8426038B2

  公开（公告）日：2013-04-23
• Synthesis and anti-norovirus activity of pyranobenzopyrone compounds
  作者：Laxman Pokhrel、Yunjeong Kim、Thi D.T. Nguyen、Allan M. Prior、Jianyu Lu、Kyeong-Ok Chang、Duy H. Hua

  DOI：10.1016/j.bmcl.2012.03.084

  日期：2012.5

  During the last decade, noroviruses have gained media attention as the cause of large scale outbreaks of gastroenteritis on cruise ships, dormitories, nursing homes, etc. Although noroviruses do not multiply in food or water, they can cause large outbreaks because approximately 10-100 virions are sufficient to cause illness in a healthy adult. Recently, it was shown that the activity of acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT1) enzyme may be important in norovirus infection. In search of anti-noroviral agents based on the inhibition of ACAT1, we synthesized and evaluated the inhibitory activities of a class of pyranobenzopyrone molecules containing amino, pyridine, substituted quinolines, or 7,8-benzoquinoline nucleus. Three of the sixteen evaluated compounds possess ED50 values in the low micrometer range. 2-Quinolylmethyl derivative 3A and 4-quinolylmethyl derivative 4A showed ED50 values of 3.4 and 2.4 mu M and TD50 values of >200 and 96.4 mu M, respectively. The identified active compounds are suitable for further modification for the development of anti-norovirus agents. (C) 2012 Elsevier Ltd. All rights reserved.
• Derivatives of Benzo (h) quinoline
  作者：Richard J. Gobeil、Cliff S. Hamilton

  DOI：10.1021/ja01220a002

  日期：1945.4