9-methylene-10-methylacridan | 41922-16-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-methylene-10-methylacridan
• 英文别名: 10-methyl-9-methylideneacridine
• CAS: 41922-16-1
• 化学式: C₁₅H₁₃N
• 分子量: 207.275
• InChiKey: MIVKFKJDCRDGFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  9-methylene-10-methylacridan 在 亚甲兰 氧气 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 10-methylspiro[acridine-9,3'-dioxetane]
  参考文献：
  名称：

  CHEMILUMINESCENCE OF 9-METHYLENEACRIDANS IN MICELLAR AND MEMBRANOUS SYSTEMS

  摘要：

  衍生自 9-亚甲基-10-十二烷基吖啶丹的 1,2-二氧杂环丁烷在水溶液中未检测到化学发光，但在胶束和膜系统中检测到。膜（2C1615G 和 2C1630G）系统中的量子产率和化学发光衰减速率受到链熔化转变的影响。结果表明，化学发光受微环境影响敏感。

  DOI：

  10.1246/cl.1981.1523
• 作为产物：
  描述：

  9,10-二甲基吖啶鎓硫酸甲酯盐 在 potassium tert-butylate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 生成 9-methylene-10-methylacridan
  参考文献：
  名称：

  CHEMILUMINESCENCE OF 9-METHYLENEACRIDANS IN MICELLAR AND MEMBRANOUS SYSTEMS

  摘要：

  衍生自 9-亚甲基-10-十二烷基吖啶丹的 1,2-二氧杂环丁烷在水溶液中未检测到化学发光，但在胶束和膜系统中检测到。膜（2C1615G 和 2C1630G）系统中的量子产率和化学发光衰减速率受到链熔化转变的影响。结果表明，化学发光受微环境影响敏感。

  DOI：

  10.1246/cl.1981.1523

文献信息

• Macrocyclic oximyl hepatitis C protease inhibitors
  申请人：Sun Ying

  公开号：US20070281884A1

  公开（公告）日：2007-12-06

  The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明揭示了化合物I的公式，或其药用可接受的盐、酯或前药：这些化合物抑制丝氨酸蛋白酶活性，特别是乙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰了乙型肝炎病毒的生命周期，同时也可用作抗病毒剂。本发明还涉及包含上述化合物的药物组合物，用于治疗患有HCV感染的受试者。该发明还涉及通过给患者投予含有本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
• CARBOCYCLIC OXIME HEPATITIS C VIRUS SERINE PROTEASE INHIBITORS
  申请人：Liu Dong

  公开号：US20090149491A1

  公开（公告）日：2009-06-11

  The present invention discloses compounds of formula I, II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. More specifically, the invention relates to oxime compounds containing a carbocyclic P2 unit. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明揭示了化合物I、II的结构，或其药用可接受的盐、酯或前药：这些化合物抑制丝氨酸蛋白酶活性，特别是乙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰了乙型肝炎病毒的生命周期，并且还可用作抗病毒剂。更具体地，本发明涉及含有环戊二烯基P2单元的肟化合物。本发明还涉及包括上述化合物的药物组合物，用于给患有HCV感染的受试者。该发明还涉及通过给予含有本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
• [EN] SYNTHESIS OF SUBSTITUTED ACRIDINES<br/>[FR] SYNTHÈSE D'ACRIDINES SUBSTITUÉES
  申请人：UNIV OF ST THOMAS

  公开号：WO2018217538A1

  公开（公告）日：2018-11-29

  Disclosed is a method of making substituted acridines. The method includes the step of reacting a bis(halophenyl) amine with an alkyne for a time and at a temperature to yield a substituted acridine.

  公开了一种制备取代吖啶的方法。该方法包括将双(卤苯基)胺与炔烃反应，经过一定时间和温度后生成取代吖啶。
• FLUORESCENT DYES BASED ON ACRIDINE AND ACRIDINIUM DERIVATIVES
  申请人：Almac Sciences (Scotland) Limited

  公开号：US20140349297A1

  公开（公告）日：2014-11-27

  The present invention relates to fluorescent dyes based on acridine and acridinium derivatives and use of such dyes in for example, biochemical and/or cell-based assays.

  本发明涉及基于吖啶和吖啶盐衍生物的荧光染料及其在生物化学和/或基于细胞的分析中的应用。
• Assay methods utilizing induced luminescence
  申请人：BEHRINGWERKE Aktiengesellschaft

  公开号：EP0515194A2

  公开（公告）日：1992-11-25

  Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises treating a medium suspected of containing an analyte under conditions such that the analyte; if present, causes a photosensitizer and a chemiluminescent compound to come into close proximity. The photosensitizer generates singlet oxygen and activates the chemiluminescent compound when it is in close proximity. The activated chemiluminescent compound subsequently produces light. The amount of light produced is related to the amount of analyte in the medium. Preferably, at least one of the photosensitizer and chemiluminescent compound is associated with a surface which is usually a suspendible particle, and a specific binding pair member is bound thereto. Another method comprises providing (1) a medium suspected of containing the analyte, (2) a label reagent comprising a first specific binding pair (sbp) member associated with a photochemically activatable chemiluminescent compound wherein the first sbp member is capable of binding to the analyte or to a second sbp member to form a complex related to the presence of the analyte. This method further comprises photochemically activating the chemiluminescent compound. The amount of luminescence generated by the chemiluminescent compound is detected. The amount thereof is related to the amount of analyte in the medium. Compositions and kits are also disclosed.

  本发明公开了测定疑似含有分析物的介质中分析物的方法。 其中一种方法包括处理疑似含有分析物的介质，处理条件是分析物（如果存在）会导致光敏剂和化学发光化合物接近。光敏剂产生单线态氧，并在靠近时激活化学发光化合物。被激活的化学发光化合物随后产生光。产生的光量与介质中分析物的含量有关。光敏剂和化学发光化合物中的至少一种最好与表面（通常是可悬浮颗粒）相关联，并与特定的结合对成员结合。 另一种方法包括：(1) 提供疑似含有分析物的介质；(2) 标签试剂，包括与光化学可激活的化学发光化合物相关的第一特异性结合对（sbp）成员，其中第一 sbp 成员能够与分析物或第二 sbp 成员结合，形成与分析物存在相关的复合物。该方法还包括光化学激活化学发光化合物。检测化学发光化合物产生的发光量。其数量与介质中分析物的数量相关。 此外，还公开了组合物和试剂盒。