7-Chloro-3-(2,4-dichloro-phenyl)-10-hydroxy-2-methyl-3,4-dihydro-2H,10H-acridine-1,9-dione | 102146-50-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-Chloro-3-(2,4-dichloro-phenyl)-10-hydroxy-2-methyl-3,4-dihydro-2H,10H-acridine-1,9-dione
• 英文别名: 7-chloro-3-(2,4-dichlorophenyl)-10-hydroxy-2-methyl-3,4-dihydro-2H-acridine-1,9-dione
• CAS: 102146-50-9
• 化学式: C₂₀H₁₄Cl₃NO₃
• 分子量: 422.695
• InChiKey: ZUZNTCRLGKBFRH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  偏二甲肼 、 7-Chloro-3-(2,4-dichloro-phenyl)-10-hydroxy-2-methyl-3,4-dihydro-2H,10H-acridine-1,9-dione 以50%的产率得到
  参考文献：
  名称：

  WERBEL, L. M.;HUNG, J.;MCNAMARA, D.;ORTWINE, D. F., EUR. J. MED. CHEM., 1985, 20, N 4, 363-370

  摘要：

  DOI：
• 作为产物：
  描述：

  5-(2,4-dichlorophenyl)-4-methyl-1,3-cyclohexanedione 、 邻硝基苯甲醛 在 盐酸 、 溶剂黄146 作用下， 反应 4.0h， 以45%的产率得到7-Chloro-3-(2,4-dichloro-phenyl)-10-hydroxy-2-methyl-3,4-dihydro-2H,10H-acridine-1,9-dione
  参考文献：
  名称：

  Antimalarial drugs. 64. Synthesis and antimalarial properties of 1-imino derivatives of 7-chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and related structures

  摘要：

  To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-[(alkylamino)alkylene]imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates. Among structural modifications prepared, including N-10-alkyl and C2-substituted analogs, removal of the C-9 oxygen, and introduction of an imino side chain at C-9, the imines of the N-10-H acridinediones were the most active compounds obtained. The [3-(NN-dimethylamino)propyl]imino derivative of 7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.

  DOI：

  10.1021/jm00097a001