2,3-difluoro-4-heptylanisole | 601478-99-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,3-difluoro-4-heptylanisole
• 英文别名: 2,3-Difluoro-1-heptyl-4-methoxybenzene
• CAS: 601478-99-3
• 化学式: C₁₄H₂₀F₂O
• 分子量: 242.309
• InChiKey: KAOIKZPXWYXTOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,3-difluoro-4-heptylanisole 在 palladium diacetate 吡啶 、 1,1'-双(二苯基膦)二茂铁 、 正丁基锂 、 甲酸 、 氢溴酸 、 溶剂黄146 、 三乙胺 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 、 环己烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 37.0h， 生成 2,3-difluoro-4-heptyl-6-methylphenylboronic acid
  参考文献：
  名称：

  Application of the Suzuki Reaction as the Key Step in the Synthesis of a Novel Atropisomeric Biphenyl Derivative for Use as a Liquid Crystal Dopant

  摘要：

  A heavily functionalized atropisomeric biphenyl derivative (4), which is designed to possess a large lateral dipole moment, has been synthesized with use of a Suzuki coupling as the key step and resolved by chiral HPLC. The final coupling reaction is complicated by rapid hydrolytic deboronation of the sterically hindered, electron poor boronate 22. Rigorously anhydrous conditions are therefore necessary to achieve the coupling.

  DOI：

  10.1021/jo034652s
• 作为产物：
  描述：

  sodium methylate 、 2,3-difluoro-4-heptyl-1-iodobenzene 在 copper(l) iodide 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以54%的产率得到2,3-difluoro-4-heptylanisole
  参考文献：
  名称：

  Application of the Suzuki Reaction as the Key Step in the Synthesis of a Novel Atropisomeric Biphenyl Derivative for Use as a Liquid Crystal Dopant

  摘要：

  A heavily functionalized atropisomeric biphenyl derivative (4), which is designed to possess a large lateral dipole moment, has been synthesized with use of a Suzuki coupling as the key step and resolved by chiral HPLC. The final coupling reaction is complicated by rapid hydrolytic deboronation of the sterically hindered, electron poor boronate 22. Rigorously anhydrous conditions are therefore necessary to achieve the coupling.

  DOI：

  10.1021/jo034652s

文献信息

• US8945420B2
  申请人：——

  公开号：US8945420B2

  公开（公告）日：2015-02-03
• Application of the Suzuki Reaction as the Key Step in the Synthesis of a Novel Atropisomeric Biphenyl Derivative for Use as a Liquid Crystal Dopant
  作者：Andrew N. Cammidge、Karen V. L. Crépy

  DOI：10.1021/jo034652s

  日期：2003.8.1

  A heavily functionalized atropisomeric biphenyl derivative (4), which is designed to possess a large lateral dipole moment, has been synthesized with use of a Suzuki coupling as the key step and resolved by chiral HPLC. The final coupling reaction is complicated by rapid hydrolytic deboronation of the sterically hindered, electron poor boronate 22. Rigorously anhydrous conditions are therefore necessary to achieve the coupling.