4-methyl-3-oxo-pentanoic acid (3-acetylphenyl)-amide | 805241-33-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methyl-3-oxo-pentanoic acid (3-acetylphenyl)-amide
• 英文别名: N-(3-Acetylphenyl)-4-methyl-3-oxopentanamide；N-(3-acetylphenyl)-4-methyl-3-oxopentanamide
• CAS: 805241-33-2
• 化学式: C₁₄H₁₇NO₃
• 分子量: 247.294
• InChiKey: MLBQMWFZLYGXIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  63.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-methyl-3-oxo-pentanoic acid (3-acetylphenyl)-amide 、 苯甲醛 在 溶剂黄146 、 β-丙氨酸 作用下， 以13%的产率得到
  参考文献：
  名称：

  [EN] SUBSTITUTED PYRROLE DERIVATIVES AND THEIR USE AS HMG-CO INHIBITORS
  [FR] DERIVES PYRROLIQUES SUBSTITUES

  摘要：

  公开号：

  WO2004106299A3
• 作为产物：
  描述：

  异丁酰醋酸甲酯 、 间氨基苯乙酮 以 xylene 为溶剂， 以49%的产率得到4-methyl-3-oxo-pentanoic acid (3-acetylphenyl)-amide
  参考文献：
  名称：

  [EN] SUBSTITUTED PYRROLE DERIVATIVES AND THEIR USE AS HMG-CO INHIBITORS
  [FR] DERIVES PYRROLIQUES SUBSTITUES

  摘要：

  公开号：

  WO2004106299A3

文献信息

• Substituted pyrrole derivatives and their use as HMG-CO inhibitors
  申请人：Ranbaxy Laboratories Limited

  公开号：EP2319843A1

  公开（公告）日：2011-05-11

  The present invention relates to substituted pyrrole derivatives, which can be used as 2-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms.

  本发明涉及可用作 2-羟基-3-甲基戊二酰辅酶 A（HMG-CoA）还原酶抑制剂的取代吡咯衍生物。本文公开的化合物可作为降低胆固醇的药物，并可用于治疗胆固醇相关疾病及相关症状。本文提供了制备所公开化合物的工艺，以及含有所公开化合物的药物组合物和治疗胆固醇相关疾病及相关症状的方法。
• Substituted Pyrrole Derivatives and Their Use as HMG-CO Inhibitors
  申请人：SALMAN Mohammad

  公开号：US20110190369A1

  公开（公告）日：2011-08-04

  The present invention relates to substituted pyrrole derivatives, which can be used as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms.
• US7923467B2
  申请人：——

  公开号：US7923467B2

  公开（公告）日：2011-04-12
• [EN] SUBSTITUTED PYRROLE DERIVATIVES AND THEIR USE AS HMG-CO INHIBITORS<br/>[FR] DERIVES PYRROLIQUES SUBSTITUES
  申请人：RANBAXY LAB LTD

  公开号：WO2004106299A3

  公开（公告）日：2005-04-28