intermedeol | 90129-04-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: intermedeol
• 英文别名: ent-Intermedeol；(1R,4aR,7S,8aR)-1,4a-dimethyl-7-prop-1-en-2-yl-2,3,4,5,6,7,8,8a-octahydronaphthalen-1-ol
• CAS: 90129-04-7
• 化学式: C₁₅H₂₆O
• 分子量: 222.371
• InChiKey: DPQYOKVMVCQHMY-GBJTYRQASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  14-hydroxy-4,5-dihydro-β-caryophyllene 在 sodium periodate 、 四氧化锇 作用下， 以 甲醇 、 水 为溶剂， 反应 0.33h， 以20 mg的产率得到intermedeol
  参考文献：
  名称：

  Bohlmann, Ferdinand; Zdero, Christa; King, Robert M., Liebigs Annalen der Chemie, 1984, # 3, p. 503 - 511

  摘要：

  DOI：

文献信息

• UTILISATION D'HUILE ESSENTIELLE D'ORIGAN OU DE BOIS DE ROSE DANS LE TRAITEMENT DES KERATOSES ACTINIQUES
  申请人：L'Oréal

  公开号：EP2538932B1

  公开（公告）日：2017-11-22
• UTILISATION D'HUILE ESSENTIELLE D'ORIGAN OU DE BOIS DE ROSE DANS LE TRAITEMENT DES KERATOSES CANCÉREUSES
  申请人：L'Oréal

  公开号：EP2538933A2

  公开（公告）日：2013-01-02
• L'HUILE ESSENTIELLE D'ORIGAN POUR LE TRAITEMENT DES KERATOSES CANCÉREUSES
  申请人：L'Oréal

  公开号：EP2538933B1

  公开（公告）日：2016-10-19
• USE OF ESSENTIAL OIL OF OREGANO AND OF ROSEWOOD, OR CONSTITUENTS THEREOF, IN THE THERAPEUTIC TREATMENT OF KERATOSES
  申请人：Marrot Laurent

  公开号：US20130059921A1

  公开（公告）日：2013-03-07

  The present invention concerns various compositions comprising the essential oil of Origanum compactum or of Aniba rosaeodora or one of their constituents, preferably a major constituent, for use in the targeted treatment and prevention of keratoses in the transformation phase and of carcinomas originating from these keratoses, and more particularly of keratoses induced by solar radiation on the skin of a subject. More particularly, the present invention concerns compositions based on the essential oil of oregano or of rosewood, or on linalool, thymol or carvacrol.
• USE OF ESSENTIAL OIL OF OREGANO OR OF ROSEWOOD, OR CONSTITUENTS THEREOF, IN THE COSMETIC TREATMENT OF KERATOSES
  申请人：Marrot Laurent

  公开号：US20150150929A1

  公开（公告）日：2015-06-04

  The present invention concerns various cosmetic uses of compositions comprising an essential oil or one of its constituents, preferably a major constituent, in the targeted treatment and prevention of benign keratoses, and more particularly keratoses induced by solar radiation on the skin of a subject. More particularly, the present invention concerns compositions based on the essential oil of oregano or of rosewood, or on linalool, thymol or carvacrol. The present invention also concerns therapeutic applications of a composition as described in the prevention or targeted treatment of actinic keratoses, essentially for prophylactic purposes.