(6R,7S,10S)-6,7-bisallyl-10-isopropenyl-7-methylspiro[4.5]dec-2-en-8-one | 1046789-46-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (6R,7S,10S)-6,7-bisallyl-10-isopropenyl-7-methylspiro[4.5]dec-2-en-8-one
• 英文别名: (6S,9S,10R)-9-methyl-6-prop-1-en-2-yl-9,10-bis(prop-2-enyl)spiro[4.5]dec-2-en-8-one
• CAS: 1046789-46-1
• 化学式: C₂₀H₂₈O
• 分子量: 284.442
• InChiKey: CMOMTZLDQYZYTG-LNLFQRSKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (6R,7S,10S)-6,7-bisallyl-10-isopropenyl-7-methylspiro[4.5]dec-2-en-8-one 在 Grubbs catalyst first generation 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以100%的产率得到(1S,4S,6R)-4-isopropenyl-1-methylbicyclo[4.4.0]decanespiro[5.1']cyclopenta-8,3'-dien-2-one
  参考文献：
  名称：

  A rapid and efficient enantiospecific synthesis of the functionalized ABC-ring system of tetranortriterpene dumsins and their analogues

  摘要：

  A rapid and enantiospecific synthesis of the ABC ring system of tetranortriterpene dumsin and its analogues, starting from the readily available monoterpene (R)-carvone employing two RCM reactions as key steps, is described. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.05.015
• 作为产物：
  描述：

  (10S)-6-allyl-10-isopropenyl-7-methylspiro[4.5]deca-2,7-dien-8-one 、 3-溴丙烯 在 氨 、 lithium 作用下， 以 四氢呋喃 、 叔丁醇 为溶剂， 反应 3.42h， 以44%的产率得到(6R,10S)-6-allyl-10-isopropenyl-7-methyl-8-(prop-2-enyloxy)spiro[4.5]deca-2,7-diene
  参考文献：
  名称：

  A rapid and efficient enantiospecific synthesis of the functionalized ABC-ring system of tetranortriterpene dumsins and their analogues

  摘要：

  A rapid and enantiospecific synthesis of the ABC ring system of tetranortriterpene dumsin and its analogues, starting from the readily available monoterpene (R)-carvone employing two RCM reactions as key steps, is described. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.05.015

文献信息

• A rapid and efficient enantiospecific synthesis of the functionalized ABC-ring system of tetranortriterpene dumsins and their analogues
  作者：Adusumilli Srikrishna、Vijendra H. Pardeshi、Pinnu Thriveni

  DOI：10.1016/j.tetasy.2008.05.015

  日期：2008.6

  A rapid and enantiospecific synthesis of the ABC ring system of tetranortriterpene dumsin and its analogues, starting from the readily available monoterpene (R)-carvone employing two RCM reactions as key steps, is described. (C) 2008 Elsevier Ltd. All rights reserved.