5-(cyanobutanoyl)-5'-(2-cyanoethyl)-4-hydroxy-2,2',3-trimethoxydiphenyl | 283159-35-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(cyanobutanoyl)-5'-(2-cyanoethyl)-4-hydroxy-2,2',3-trimethoxydiphenyl
• 英文别名: 5-[5-[5-(2-Cyanoethyl)-2-methoxyphenyl]-2-hydroxy-3,4-dimethoxyphenyl]-5-oxopentanenitrile
• CAS: 283159-35-3
• 化学式: C₂₃H₂₄N₂O₅
• 分子量: 408.454
• InChiKey: HFFHXCRQRXOCRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5-(cyanobutanoyl)-5'-(2-cyanoethyl)-4-hydroxy-2,2',3-trimethoxydiphenyl 在 三氟化硼乙醚 sodium cyanoborohydride 作用下， 以 四氢呋喃 为溶剂， 反应 56.0h， 以64%的产率得到5-[5'-(2-Cyano-ethyl)-4-hydroxy-5,6,2'-trimethoxy-biphenyl-3-yl]-pentanenitrile
  参考文献：
  名称：

  Isolation of Macrocyclic Metacyclophanes From the Attempted Synthesis of [7.0]Metacyclophanes of the Myricanone Series by Thorpe-Ziegler - Intramolecular Cyclization of Diaryls Substituted by ω-Cyanoalkyl Chains

  摘要：

  The syntheses of the diaryls 14 and 21, substituted by two omega-cyanoalkyl chains (one on each ring), are described. Treatment of the unsymmetrical diaryl 14 with NaN(Me)Ph in a Thorpe-Ziegler reaction failed to give any definite product. Under the same conditions the symmetrical diaryl 21 led to an isomeric mixture of dimeric enaminonitriles 24. Mild acidic hydrolysis of the latter yielded the isomeric beta-ketonitriles 25, whereas more drastic hydrolytic conditions led to the macrocyclic diketone 26.

  DOI：

  10.1002/(sici)1099-0690(200004)2000:8<1527::aid-ejoc1527>3.0.co;2-g
• 作为产物：
  描述：

  2,3,4-三甲氧基苯硼酸 在 氢氧化钾 、 四(三苯基膦)钯 三氯化铝 、 sodium carbonate 、 magnesium 作用下， 以 1,4-二氧六环 、 甲醇 、 乙二醇二甲醚 、 乙醇 、 硝基苯 为溶剂， 反应 35.0h， 生成 5-(cyanobutanoyl)-5'-(2-cyanoethyl)-4-hydroxy-2,2',3-trimethoxydiphenyl
  参考文献：
  名称：

  Isolation of Macrocyclic Metacyclophanes From the Attempted Synthesis of [7.0]Metacyclophanes of the Myricanone Series by Thorpe-Ziegler - Intramolecular Cyclization of Diaryls Substituted by ω-Cyanoalkyl Chains

  摘要：

  The syntheses of the diaryls 14 and 21, substituted by two omega-cyanoalkyl chains (one on each ring), are described. Treatment of the unsymmetrical diaryl 14 with NaN(Me)Ph in a Thorpe-Ziegler reaction failed to give any definite product. Under the same conditions the symmetrical diaryl 21 led to an isomeric mixture of dimeric enaminonitriles 24. Mild acidic hydrolysis of the latter yielded the isomeric beta-ketonitriles 25, whereas more drastic hydrolytic conditions led to the macrocyclic diketone 26.

  DOI：

  10.1002/(sici)1099-0690(200004)2000:8<1527::aid-ejoc1527>3.0.co;2-g

文献信息

• Isolation of Macrocyclic Metacyclophanes From the Attempted Synthesis of [7.0]Metacyclophanes of the Myricanone Series by Thorpe-Ziegler - Intramolecular Cyclization of Diaryls Substituted by ω-Cyanoalkyl Chains
  作者：Bénédicte Dansou、Christophe Pichon、Robert Dhal、Eric Brown、Stéphane Mille

  DOI：10.1002/(sici)1099-0690(200004)2000:8<1527::aid-ejoc1527>3.0.co;2-g

  日期：2000.4

  The syntheses of the diaryls 14 and 21, substituted by two omega-cyanoalkyl chains (one on each ring), are described. Treatment of the unsymmetrical diaryl 14 with NaN(Me)Ph in a Thorpe-Ziegler reaction failed to give any definite product. Under the same conditions the symmetrical diaryl 21 led to an isomeric mixture of dimeric enaminonitriles 24. Mild acidic hydrolysis of the latter yielded the isomeric beta-ketonitriles 25, whereas more drastic hydrolytic conditions led to the macrocyclic diketone 26.