N-异丙基噻唑烷硫酮 | 6328-13-8

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: N-异丙基噻唑烷硫酮
• 中文别名: 3-异丙基噻唑烷-2-硫酮
• 英文名称: 3-isopropylthiazolidine-2-thione
• 英文别名: 3-isopropyl-thiazolidine-2-thione；N-Isopropylthiazolin-2-thion；2-Thiazolidinethione, 3-isopropyl-；3-propan-2-yl-1,3-thiazolidine-2-thione
• CAS: 6328-13-8
• 化学式: C₆H₁₁NS₂
• 分子量: 161.292
• InChiKey: VHIUJZKOEFEDAF-UHFFFAOYSA-N

物化性质

• 沸点：
  220℃
• 密度：
  1.18
• 闪点：
  87℃

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  60.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-巯基噻唑啉 、 2-溴丙烷 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以66%的产率得到N-异丙基噻唑烷硫酮
  参考文献：
  名称：

  Reaction of 2-thiazolidinethione with halohydrocarbon: synthesis of novel N-alkylated 2-thiazolidinethione and S-alkylated thiazoline derivatives

  摘要：

  Reaction of 2-thiazolidinethione with halohydrocarbon in ethanol gave a series of N-alkylated 2-thiazolidinethione and S-alkylated thiazoline derivatives in excellent yields. The reaction was carried out under mild conditions using NaOH as a base and it did not require protection from air.

  DOI：

  10.1515/hc.2010.015

文献信息

• INTERMEDIATES FOR PREPARING HALICHONDRIN COMPOUNDS AND PREPARATION METHOD THEREFOR
  申请人：Beijing Tienyi Lufu Pharmatech Co. Ltd.

  公开号：EP3686208A1

  公开（公告）日：2020-07-29

  The invention relates to intermediates useful in the preparation of halichondrin compounds, methods for preparing the same and use thereof, such as halichondrins, eribulin, or their analogs. The intermediates, the methods and use thereof are used for the synthensis of the C20-C26 fragment of halichondrin compounds. The raw materials in the synthetic route of the invention are cheap and easily obtained, the sources and the qualities of the raw materials are reliable. The choice of the methods useful in the synthesis of chiral central structures are based on the structural characteristics of the reactants, thus effectively improving the synthesis efficiency, reducing the difficulties and risks of product quality control, and avoiding the use of highly toxic and expensive organotin catalysts to significantly decrease costs and improve environmental friendliness.

  本发明涉及可用于制备卤虫菊酯化合物的中间体、制备方法及其用途，如卤虫菊酯、麦饭石菊酯或其类似物。这些中间体、制备方法及其用途用于合成卤代糖化合物的 C20-C26 片段。本发明合成路线中的原料便宜且容易获得，原料来源和质量可靠。根据反应物的结构特征选择有用的方法合成手性中心结构，从而有效地提高了合成效率，降低了产品质量控制的难度和风险，避免了剧毒和昂贵的有机锡催化剂的使用，大大降低了成本，提高了环境友好性。
• Macrocyclic HOPO chelators
  申请人：LUMIPHORE, INC.

  公开号：US10352938B2

  公开（公告）日：2019-07-16

  The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability.

  本发明提供了一类新型大环化合物以及金属（如镧系元素）离子与本发明化合物之间形成的配合物。优选的配合物在水介质中表现出高稳定性和高镧系离子发光量子产率，无需使用二级活化剂。优选化合物在其大环结构中包含羟基吡啶壬基，其特点是与抗体和蛋白质等多种多肽的非特异性结合率低得出奇，并且具有很高的动力学稳定性。
• Bafford,R.A. et al., Bulletin de la Societe Chimique de France, 1973, p. 971 - 977
  作者：Bafford,R.A. et al.

  DOI：——

  日期：——
• Verfahren zur Herstellung von Thiazolidin-2-thionen
  申请人：BAYER AG

  公开号：EP0017039B1

  公开（公告）日：1983-01-12
• ENANTIOMERIC CYNEMICIN ANALOGS, PREPARATION AND USE THEREOF
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：EP0641207A1

  公开（公告）日：1995-03-08