(6Z)-6-[[2-[[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]ethylamino]methylidene]cyclohexa-2,4-dien-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (6Z)-6-[[2-[[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]ethylamino]methylidene]cyclohexa-2,4-dien-1-one
• 化学式: C₁₆H₁₆N₂O₂
• 分子量: 268.31
• InChiKey: RQHVNNWVDLRULK-HEEUSZRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  copper(II) acetate 、 (6Z)-6-[[2-[[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]ethylamino]methylidene]cyclohexa-2,4-dien-1-one 在 氩 作用下， 以 乙醇 为溶剂， 反应 24.0h， 生成 二水杨醛缩乙二胺铜
  参考文献：
  名称：

  Metal-conjugated microporous polymers

  摘要：

  一种催化剂，可在0~180℃，0.1~8.0 MPa下催化CO2和烷基环氧化物的环加成反应，生成相应的环碳酸酯，以及其制备方法。该催化剂是一种共轭微孔大分子聚合物，与钴、铬、锌、铜或铝形成配合物。通过使用不同金属配合的大分子催化剂在常温常压下催化CO2和烷基环氧化物的反应，可以获得35%~90%的相应环碳酸酯收率。该催化剂易于回收，重复使用不影响收率；此外，通过控制反应条件，收率可以达到90%以上。

  公开号：

  US20160251331A1
• 作为产物：
  描述：

  水杨醛 、 乙二胺 以 乙醇 、 水 为溶剂， 反应 17.08h， 以to yield 25.733 g (95.9%) of salen的产率得到(6Z)-6-[[2-[[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]ethylamino]methylidene]cyclohexa-2,4-dien-1-one
  参考文献：
  名称：

  Chiral catalysts and catalytic epoxidation catalyzed thereby

  摘要：

  本发明公开了使用手性催化剂对原始手性烯烃进行对映选择性环氧化和对映选择性氧化原始手性硫化物的方法。根据本发明的一个方面，所使用的催化剂是具有以下一般结构的萨伦衍生物：##STR1## 根据本发明的另一个方面，公开了使用手性催化剂制备环氧色酮的方法。根据该方法，在所需的条件和时间下，将色酮衍生物、氧原子来源和手性催化剂反应，以使色酮衍生物环氧化。根据本发明的另一个方面，公开了对顺式肉桂酸衍生物进行对映选择性环氧化以制备紫杉醇或其类似物的方法。根据另一个方面，公开了使用本发明的催化剂进行过氧化氢不均化的方法。

  公开号：

  US05637739A1

文献信息

• Process for treating textile materials
  申请人：——

  公开号：US20010023238A1

  公开（公告）日：2001-09-20

  A process for preventing the redeposition of migrant dyes in a washing liquor by adding to each liter of the washing liquor, which comprises a peroxide-containing detergent, from 0.5 to 150 mg of one or more asymmetric manganese complexes of the salen type.

  一种防止迁移染料在洗涤液中重新沉淀的方法，是向每升含有过氧化物的洗涤剂的洗涤液中添加0.5至150毫克一种或多种不对称的Salen型锰配合物。
• Chiral catalysts and epoxidation reactions
  申请人：Research Corporation Technologies, Inc.

  公开号：US05663393A1

  公开（公告）日：1997-09-02

  Chiral catalysts for enantioselectively epoxidizing a prochiral olefin and for enantioselectively oxidizing a prochiral sulfide are disclosed, together with methods of using such catalysts. In accordance with one aspect of the invention, the catalyst is a salen derivative which has the following general structure: ##STR1## In accordance with another aspect of the present invention is a method of, producing an epoxychroman using a chiral catalyst. In accordance with this method, a chromene derivative, an oxygen atom source, and a chiral catalyst are reacted under such conditions and for such time as is needed to epoxidize said chromene derivative. In accordance with yet another aspect of this invention is a method of enantioselectively epoxidizing a cis-cinnamate derivative to make taxol or an analog thereof. In accordance with another aspect a method of disproportionation of hydrogen peroxide using the catalysts of the present invention is disclosed.

  本发明揭示了用于对拟手性烯烃进行对映选择性环氧化和对拟手性硫醚进行对映选择性氧化的手性催化剂，以及使用这种催化剂的方法。根据本发明的一个方面，催化剂是一个萨林衍生物，具有以下一般结构：##STR1## 根据本发明的另一个方面，揭示了使用手性催化剂制备环氧色酮的方法。根据这种方法，将色酮衍生物、氧原子源和手性催化剂在所需的条件和时间下反应，以使色酮衍生物环氧化。根据本发明的另一方面，揭示了一种对顺式肉桂酸衍生物进行对映选择性环氧化以制备紫杉醇或其类似物的方法。根据另一个方面，揭示了使用本发明的催化剂进行过氧化氢的不均化反应的方法。
• Method for producing optically active lactone compounds by using salen cobalt complexes having a cis-beta structure
  申请人：Kyushu University

  公开号：US20030120091A1

  公开（公告）日：2003-06-26

  A method for producing an optically active lactone compound by Baeyer-Villiger oxidation of a cyclic ketone compound with at least one kind of oxidants selected from the group consisting of hydrogen peroxide and urine-hydrogen peroxide adduct (UHP) using a cobalt(salen) complex having a cis-&bgr; structure expressed by the following formula (I) or (II) as a catalyst. 1 in which X and Y independently denote H, a t-butyl group or an electron-withdrawing substituting group and W is a halogen element. 2 in which X and Y independently denote H, a t-butyl group or an electron-withdrawing substituting group and Z − is a monovalent anion. The optically active lactone compounds can be used for the synthesis of medicines and argochemicals.

  一种通过使用氢过氧化物或尿素-氢过氧化物加合物（UHP）中至少一种氧化剂，利用具有以下式（I）或（II）所表示的具有顺式β结构的钴（salen）配合物作为催化剂，对环状酮化合物进行Baeyer-Villiger氧化而制备光学活性内酯化合物的方法。 式（I）和（II）中，X和Y独立地表示氢，叔丁基基团或电子提取取代基，W为卤素元素，Z-为一价阴离子。这些光学活性内酯化合物可用于合成药物和农药。
• Rigidified Compounds for Modulating Heparanase Activity
  申请人：Gelder M. Van Joel

  公开号：US20080039456A1

  公开（公告）日：2008-02-14

  Disclosed are novel rigidified compounds having a rhodanine-like residue and at least one aryl or heteroaryl residue linked to the rhodanine-like residue, whereby a core structure of these compounds, as defined in the specification, is characterized as having one or zero free-to-rotate bonds. Also disclosed are pharmaceutical compositions containing these rigidified compounds and uses thereof for modulating the activity of heparanase and hence in the treatment of heparanase-associated diseases and disorders, and uses thereof for modulating the activity of heparin-binding proteins and hence in the treatment of heparin-binding proteins-associated diseases and disorders as well as in the treatment of medical conditions that are at least partially treatable by rhodanine or a rhodanine analog.

  本发明涉及一种新颖的硬化化合物，其具有类罗丹明残基和至少一个连接到类罗丹明残基的芳基或杂环芳基残基，其中这些化合物的核心结构定义在规范中，其具有一个或零个可自由旋转的键。本发明还涉及含有这些硬化化合物的制药组合物及其在调节肝素酶活性和因此治疗肝素酶相关疾病和疾病方面的用途，以及其在调节肝素结合蛋白活性和因此治疗肝素结合蛋白相关疾病和疾病方面的用途，以及在至少部分可通过罗丹明或罗丹明类似物治疗的医疗条件方面的用途。
• Method for monitoring the stereoselectivity and relative rate of organic chemical reactions
  申请人：Berkowitz B. David

  公开号：US20060263895A1

  公开（公告）日：2006-11-23

  A method for monitoring the stereoselectivity of at least one organic chemical reaction and the relative rate of at least one organic chemical reaction, wherein the reaction produces a product that can exist as at least two stereoisomers, the process comprising: providing a first reaction zone containing (1) an organic phase comprising the reaction mixture for producing the product and (2) an aqueous phase adjacent to, but substantially immiscible with the organic phase, the aqueous phase containing at least one first sensing agent that preferentially acts on a first stereoisomer in the product to produce a monitorable change, the product being diffusible into the aqueous layer (2). providing a second reaction zone containing (A) an organic phase also comprising the reaction mixture for producing the product and (B) an aqueous phase adjacent to, but substantially immiscible with the organic phase, the aqueous phase containing at least one sensing agent that is different from the first sensing agent and that [i] also preferentially acts on the first stereoisomer in the product, but with a different stereoselectivity for the stereoisomers formed in the product than the first sensing agent to produce a monitorable change or [ii] acts at equal rates on both formed stereoisomers of the product to produce a monitorable change or [iii] preferentially acts on a second stereoisomer in the product to produce a monitorable change, the product being diffusible into the aqueous layer (B), conducting the reactions in the organic phases (1) and (A) to produce the products, allowing the products to diffuse into the aqueous phases (2) and (B) and react with the first and second sensing agents, monitoring the changes caused by the reactions with the first and second sensing agents and determining from the changes the relative rate and stereoselectivity of the organic chemical reaction in the organic phases (1) and (2). Also disclosed are methods for identifying and preparing catalysts for the above reactions.

  一种用于监测至少一种有机化学反应的立体选择性和至少一种有机化学反应的相对速率的方法，其中该反应产生的产物可以存在至少两个立体异构体，该过程包括：提供第一反应区，其中包含（1）用于产生产物的反应混合物的有机相和（2）与有机相相邻但与有机相不相混的水相，水相含有至少一种第一感应剂，该感应剂优先作用于产物中的第一立体异构体以产生可监测的变化，产物可扩散到水层（2）；提供第二反应区，其中包含（A）也包括用于产生产物的反应混合物的有机相和（B）与有机相相邻但与有机相不相混的水相，水相含有至少一种感应剂，该感应剂与第一感应剂不同，并且[i] 也优先作用于产物中的第一立体异构体，但其立体选择性与第一感应剂形成的产物的立体异构体不同，以产生可监测的变化，或者[ii] 在产物的两个形成的立体异构体上以相等的速率作用，以产生可监测的变化，或者[iii] 优先作用于产物中的第二立体异构体以产生可监测的变化，产物可扩散到水层（B）；在有机相（1）和（A）中进行反应以产生产物，使产物扩散到水相（2）和（B）并与第一和第二感应剂反应，监测由第一和第二感应剂反应引起的变化，并从变化中确定有机化学反应在有机相（1）和（2）中的相对速率和立体选择性。还公开了用于识别和制备上述反应的催化剂的方法。