copper(II) acetate | 19955-76-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: copper(II) acetate
• 英文别名: copper diacetate；Bis(acetato-|EO,|EO inverted exclamation marka)copper；copper;diacetate
• CAS: 19955-76-1
• 化学式: C₄H₆CuO₄
• 分子量: 181.635
• InChiKey: OPQARKPSCNTWTJ-UHFFFAOYSA-L

物化性质

• 熔点：
  115 °C
• 蒸气密度：
  6.9 (vs air)
• 物理描述：
  Cupric acetate appears as a blue-green crystalline solid. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. It is used as an insecticide, in the preparation of other chemicals, as a fungicide, and mildew preventive.
• 颜色/状态：
  Blue-green hydroscopic powder
• 密度：
  1.9 at 68 °F (USCG, 1999)
• 分解：
  When heated to decomposition it emits acrid smoke & irritating fumes.

计算性质

• 辛醇/水分配系数(LogP)：
  -2.49
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。 肾毒素 - 该化学品在职业环境中可能对肾脏有毒。 高铁血红蛋白血症 - 血液中高铁血红蛋白含量增加；该化合物被归类为第二级毒性效应。 溶血性贫血 - 血红蛋白或红细胞数量减少。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting. Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect Hemolytic anemia - Decreased hemoglobin or number of red blood cells.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 相互作用

铜乙酸对大鼠二甲基亚硝胺诱导的肝致癌作用的影响进行了研究。在仅给予饮用水中二甲基亚硝胺（25 ppm）的组中，存活的大鼠在26周时被处死，发现16只大鼠中有12只发展出了肝肿瘤。在给予二甲基亚硝胺和铜乙酸的组中，22只大鼠中有7只发展出了肝肿瘤。因此，给予二甲基亚硝胺和铜乙酸的大鼠肝肿瘤的发生率仅为单独给予二甲基亚硝胺的大鼠的大约40%。在给予盐水或单独铜乙酸的组中没有观察到肿瘤。铜乙酸给药显著抑制了给予二甲基亚硝胺的大鼠肝DNA中胸腺嘧啶的掺入。铜乙酸皮下注射也显著抑制了给予单次剂量二甲基亚硝胺的大鼠肝DNA的甲基化；O6-甲基鸟嘌呤和7-甲基鸟嘌呤的形成都减少了。这个结果提示，铜乙酸的皮下注射可能对肝脏致癌作用的起始阶段具有抑制作用。

The effect of cupric acetate on dimethylnitrosamine induced hepatocarcinogenesis in rats was investigated. The surviving rats in the group given dimethylnitrosamine (25 ppm) in the drinking water alone were killed at 26 wk and it was found that 12 of 16 rats had developed liver tumors. In the group given dimethylnitrosamine and cupric acetate (sc injections of 2 copper/kg once a week for 26 wk), 7 of 22 rats developed liver tumors. The incidence of liver tumors in rats given dimethylnitrosamine and cupric acetate was thus only about 40% of that in rats given dimethylnitrosamine alone. No tumor was observed in the group given saline or cupric acetate alone. The thymidine incorporation into the liver DNA of rats given dimethylnitrosamine was significantly suppressed by the administration of cupric acetate. The methylation of liver DNA in rats given a single dose of dimethylnitrosamine was also significantly suppressed by sc injection of cupric acetate; the formation of both O6-methylguanine and 7-methylguanine was reduced. This result suggests that sc injection of cupric acetate may have a suppressive effect on the initiation of carcinogenesis in the liver.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

D- L- 乙硫氨酸在大鼠肝脏病变中可显著增加血清黄嘌呤脱氢酶活性。醋酸铜是黄嘌呤脱氢酶活性的强效抑制剂（Ki = 3.42 × 10（-6）M）。乙硫氨酸通过形成一种与游离乙硫氨酸行为不同的铜复合物，从而抵抗醋酸铜的抑制作用。

Hepatic lesions by D-L-ethionine in rats produce a significant increase in the blood serum xanthine dehydrogenase activity. Cupric acetate is a potent inhibitor (Ki = 3.42 X 10(-6) M) of the xanthine dehydrogenase activity. Ethionine protects against the inhibitory effect of cupric acetate by formation of a copper complex with behaviour different from that of free ethionine.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

铜乙酸和黄曲霉毒素膳食补充剂对雄性大鼠血清维生素A和E、白蛋白、胆固醇和血液形成元素的影响进行了研究。铜乙酸的膳食补充剂量为0.5%，黄曲霉毒素的膳食补充剂量为7.8 ppm。无论是哪种补充剂，维生素A和E、红细胞计数（RBC）、平均细胞体积（MCV）、平均细胞血红蛋白含量（MCHC）和血细胞比容（Hct）均未显著改变，而接受铜乙酸或黄曲霉毒素的组的白蛋白和胆固醇显著升高。在接受黄曲霉毒素+铜乙酸补充剂的动物中，血清血红蛋白（HBG）降低，而在接受铜乙酸的两组中，白细胞（WBC）计数降低，而黄曲霉毒素没有影响。

The effects of copper acetate and aflatoxin dietary supplements on serum vitamins A and E, albumin, cholesterol and the formed elements of blood in male rats were investigated. CuAc and aflatoxin dietary supplements were 0.5% and 7.8 ppm, respectively. Vitamins A and E, red blood cell count (RBC), mean cell volume (MCV), mean cell Hb content (MCHC) and hematocrit (Hct) were not significantly altered by either supplement while albumin and cholesterol was significantly elevated in groups receiving CuAc or aflatoxin. Serum Hb (HBG) was depressed in animals receiving aflatoxin + CuAc supplement while the WBC (white blood cell) count was depressed in both groups receiving CuAc while aflatoxin had no effect.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

慢性铜醋酸中毒对大鼠的影响（饮水中含0.125%，持续30天）在形态学上或通过血清转氨酶的测量没有检测到肝坏死，但在肝脏的分离和灌注过程中，发现了胆汁和溴磺酚绿的分泌能力降低。因此，在明显的结构损伤变得明显之前，肝细胞中铜的积累可能会损害肝脏功能。

Chronic poisoning of rats with copper acetate (0.125% in the drinking water for 30 days) caused no liver necrosis that could be detected morphologically or by measurement of serum transaminases, but upon isolation and perfusion of the liver, reduced bile and bromsulfalein secreting capacities were found. Accumulation of copper in the hepatocytes may thus impair liver function before overt structural damage becomes evident.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

关于实验动物中铜毒性的数据有限。在给予含5,000 ppm醋酸铜的饮食16个月的大鼠中，观察到肝脏和肾脏中铜的严重积累。在饮用含1250 ppm单水合醋酸铜的饮用水长达902天的大鼠的肝脏、肾脏、大脑以及大小肠中也看到了类似的沉积物。

There are limited data concerning toxicity of copper in experimental animals. Heavy accumulation of copper was observed in the liver and kidneys of rats maintained for 16 mo on a diet supplemented with 5,000 ppm copper acetate. Similar depositions were seen in the liver and kidney as well as the brain and the large and small bowel in rats exposed to 1250 ppm cupric acetate monohydrate in the drinking water for up to 902 days.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险品标志：
  Xn,N
• 安全说明：
  S26,S60,S61
• 危险类别码：
  R22
• 海关编码：
  2915299011
• 危险品运输编号：
  UN 3077 9/PG 3

反应信息

• 作为反应物：
  描述：

  copper(II) acetate 以31%的产率得到
  参考文献：
  名称：

  HOOD, J. N. C.;LLOYD, D.;MACDONALD, W. A.;SHEPHERD, T. M., TETRAHEDRON, 1982, 38, N 22, 3355-3358

  摘要：

  DOI：
• 作为产物：
  描述：

  溶剂黄146 生成 copper(II) acetate
  参考文献：
  名称：

  PALFY, ANTON

  摘要：

  DOI：
• 作为试剂：
  描述：

  谷胱甘肽 、 顺丁烯二酸 、 碘 、 在 reaction mixture 碘 、 copper(II) acetate 、 乙醇 、 铜 、 water ethanol 、 水 、 硫化氢 、 硫化铜,一水 作用下， 以 水 为溶剂， 反应 12.0h， 以Thus is obtained about 9 g of the title compound as white amorphous crystals (hygroscopic)的产率得到S-(1,2-二甲酰基乙基)谷胱甘肽
  参考文献：
  名称：

  Anticataract composition

  摘要：

  该发明提供了一种抗白内障组合物，其中包含以下式子的化合物##STR1## [其中Rs相同或不同，每个表示氢原子或低碳基]或其药理学上可接受的盐。本发明的抗白内障组合物对于预防和治疗各种类型的白内障包括老年性白内障和糖尿病性白内障非常有用。

  公开号：

  US05212159A1

文献信息

• Unexpected Formation of the Mixed Ligand Complexes [Cu(OAc)(bipy)2]Cl·4H2O·1/2MeOH and [Co(OH2)2(phen)2](OAc)2·6H2O, and their Crystal Structures
  作者：R. Carballo、B. Covelo、E. M. Vázquez-López、E. García-Martínez

  DOI：10.1002/zaac.200390039

  日期：2003.2

  /2MeOH und [Co(OH2)2(phen)2](OAc)2·6H2O und ihre Kristallstrukturen Die einkernigen Verbindungen [Cu(OAc)(bipy)2]Cl·4H2O·1/2MeOH (1) und [Co(OH2)2(phen)2](OAc)2·6H2O (2) wurden unerwartert als Einkristalle aus Mutterlaugen der erwarteten Produkte der Reaktion von Cu(OAc)2, Benzylsaure und 2, 2′-Bipyridin (fur 1) und Co(OAc)2, D, L-Mandelsaure und 1, 10-Phenanthrolin (fur 2) in Ethanol erhalten. Die

  单核化合物[Cu(OAc)(bipy)2]Cl·4H2O·1/2MeOH(1)和[Co(OH2)2(phen)2](OAc)2·6H2O(2)意外地以单晶形式获得从反应的预期产物分离后留下的母液中，在乙醇中的 Cu(OAc)2、苄酸和 2, 2'-联吡啶（对于 1）和 Co(OAc)2、D、L-扁桃酸和1、10-菲咯啉（2）。配合物在室温下通过元素分析、红外和电子光谱以及磁测量表征，并通过单晶 X 射线分析确定其结构。在 1 中，五配位铜原子具有基本的方形金字塔配位多面体，而在 2 中，钴原子具有扭曲的八面体环境。在这两种情况下，复合物都是通过氢键和芳香-芳香相互作用连接起来的。Unerwartete Bildung der Gemischtligand-Komplexe [Cu(OAc)(bipy)2]Cl·4H2O-·1/2MeOH 和 [Co(OH2)2(phen)2](OAc)2·6H2O
• Barrier layer arrangement for conductive layers on silicon substrates
  申请人：Eastman Kodak Company

  公开号：US04908348A1

  公开（公告）日：1990-03-13

  A barrier layer triad intended to protect a silicon substrate and an overlying conductive layer from mutual contamination is disclosed as well as a process for its preparation. The barrier layer triad is comprised of a first triad layer located adjacent the silicon substrate consisting essentially of silica, a third triad layer remote from the silicon substrate consisting essentially of at least one Group 4 heavy metal oxide, and a second triad layer interposed between the first and third triad layers consisting essentially of a mixture of silica and at least one Group 4 heavy metal oxide.

  本发明揭示了一种用于保护硅衬底和上层导电层不互相污染的屏障层三元组，以及其制备方法。该屏障层三元组由三个层组成，第一个三元组层位于硅衬底旁边，主要由二氧化硅组成；第三个三元组层远离硅衬底，主要由至少一种第四族重金属氧化物组成；第二个三元组层位于第一个和第三个三元组层之间，主要由二氧化硅和至少一种第四族重金属氧化物的混合物组成。
• Copper containing ballistic additives
  申请人：The United States of America as represented by the Secretary of the Air

  公开号：US04391660A1

  公开（公告）日：1983-07-05

  This invention concerns itself with the addition of certain copper salts and chelates to solid propellant formulations as burning rate modifiers. The additives increase the burning rate of the propellant while simultaneously decreasing its pressure exponent.

  这项发明涉及将某些铜盐和螯合物添加到固体推进剂配方中作为燃速修饰剂。这些添加剂可以增加推进剂的燃烧速率，同时降低其压力指数。
• Process for forming metal oxide superconductors from a precursor
  申请人：Akzo America Inc.

  公开号：US04923849A1

  公开（公告）日：1990-05-08

  Metal oxide superconductors of the yttrium-barium-copper type can be formed by precipitation from an aqueous solution of the salts of the metals using an oxalate precipitation reagent under basic pH conditions to form a fireable precursor only partly in the form of the oxalate salts of these metals.

  采用草酸沉淀试剂，在碱性pH条件下，从金属盐的水溶液中沉淀，形成钇钡铜型金属氧化物超导体的可烧性前体，该前体仅部分以这些金属的草酸盐形式存在。
• Catalyst and method for producing carbonic diesters
  申请人：Daicel Chemical Industries, Ltd.

  公开号：US05405986A1

  公开（公告）日：1995-04-11

  A catalyst for synthesizing a carbonic diester includes at least one copper compound selected from among copper oxides, copper hydroxides, a salt of copper with a weak acid consisting of the elements other than halogen such as copper borates, and complexes or complex salts consisting of the elements other than halogen and formed with copper or a copper compound a and ligand. The catalyst has a high activity, a high reaction selectivity and excellent stability with a minimal risk of corroding equipment. The catalyst can include, as a co-catalyst component, a platinum-group metal such as palladium or a halogen-free platinum-group metal compound such as palladium acetate. The catalyst component may be supported on a carrier, for example, an activated carbon. A carbonic diester is advantageously produced by allowing an alcohol to react with carbon monoxide and oxygen in the presence of the catalyst. The corrosion due to the catalyst is considerably inhibited so that a dimethyl carbonate can be produced with an excellent stability for a long duration.

  合成碳酸二酯的催化剂包括至少一种铜化合物，选自氧化铜、氢氧化铜、铜与弱酸盐（由除卤素以外的元素组成的酸盐，例如铜硼酸盐）以及由铜或铜化合物和配体组成的元素（除卤素）的配合物或配合物盐。该催化剂具有高活性、高反应选择性和优异的稳定性，并具有对设备腐蚀风险最小的特点。该催化剂可以包括铂族金属（如钯）或无卤铂族金属化合物（如乙酸钯）作为共催化剂组分。催化剂组分可以负载在载体上，例如活性炭。在催化剂存在下，通过让醇与一氧化碳和氧反应，可以优势地生产碳酸二酯。由于催化剂的腐蚀作用得到了显著抑制，因此可以在很长时间内产生具有优异稳定性的二甲基碳酸酯。