p-<(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-propenyl>-2-methyl-benzoic acid ethylester | 71441-12-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: p-<(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-propenyl>-2-methyl-benzoic acid ethylester
• 英文别名: p-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]-2-methyl-benzoic acid ethyl ester；ethyl 2-methyl-4-[(E)-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]benzoate
• CAS: 71441-12-8
• 化学式: C₂₇H₃₄O₂
• 分子量: 390.566
• InChiKey: KNXSPRQSYPCLHC-OBGWFSINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(5,5,8,8-四甲基-5,6,7,8-四氢萘-2-基)乙烷-1-酮 在 吡啶 四氢呋喃 、 sodium tetrahydroborate 、 三溴化磷 作用下， 以 甲醇 、 乙醚 、 正己烷 、 xylene 为溶剂， 反应 64.0h， 生成 p-<(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-propenyl>-2-methyl-benzoic acid ethylester
  参考文献：
  名称：

  Loeliger; Bollag; Mayer, European Journal of Medicinal Chemistry, 1980, vol. 15, # 1, p. 9 - 15

  摘要：

  DOI：

文献信息

• Stilbene derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US04326055A1

  公开（公告）日：1982-04-20

  This invention is directed to 5,6,7,8-tetrahydro-naphthyl or indanyl stilbene derivatives which are useful as tumor inhibiting agents, in the treatment of neoplasms, dermatological conditions and rheumatic illnesses.

  本发明涉及5,6,7,8-四氢萘基或茚基苯乙烯衍生物，其可用作肿瘤抑制剂，在治疗肿瘤、皮肤病和风湿病方面具有用途。
• Method to incorporate N-(4-hydroxyphenyl) retinamide in liposomes
  申请人：Board of Regents, The University of Texas System

  公开号：US20020143062A1

  公开（公告）日：2002-10-03

  Disclosed herein are simple and unique methods of methods of preparing liposomal compositions of N-(4-hydroxyphenyl) retinamide (4HPR) and/or other retinoids. Also disclosed are liposomal 4HPR compositions prepared by such methods, and use of such compositions in the treatment of diseases, such as breast cancer. This invention further provides methods for improving the efficacy of N-(4-hydroxyphenyl) retinamide (4HPR) as a chemopreventive agent in the presence of agents that potentiates its ability increase the expression of inducible nitric oxide synthase (iNOS, and NO production in cells.

  本文披露了制备N-(4-羟基苯基)视黄酰胺（4HPR）和/或其他视黄醇脂质体组合物的简单且独特的方法。还披露了通过这些方法制备的脂质体4HPR组合物，并将这种组合物用于治疗疾病，如乳腺癌。本发明还提供了一种方法，通过增强诱导型一氧化氮合酶（iNOS）和细胞内NO产生的能力，提高N-(4-羟基苯基)视黄酰胺（4HPR）作为化学预防剂的功效。
• A METHOD TO INCORPORATE N-(4-HYDROXYPHENYL) RETINAMIDE IN LIPOSOMES
  申请人：Board of Regents, The University of Texas System

  公开号：EP1328262A2

  公开（公告）日：2003-07-23
• US4326055A
  申请人：——

  公开号：US4326055A

  公开（公告）日：1982-04-20
• [EN] A METHOD TO INCORPORATE N-(4-HYDROXYPHENYL) RETINAMIDE IN LIPOSOMES<br/>[FR] PROCEDE SERVANT A INCORPORER DU N-(4-HYDROXYPHENYL) RETINAMIDE DANS DES LIPOSOMES
  申请人：UNIV TEXAS

  公开号：WO2002032413A2

  公开（公告）日：2002-04-25

  Disclosed herein are simple and unique methods of methods of preparing liposomal compositions of N-(4-hydroxyphenyl) retinamide (4HPR) and/or other retinoids. Also disclosed are liposomal 4HPR compositions prepared by such methods and use of such compositions in the treatment of diseases, such as breast cancer. This invention further provides methods for improving the efficacy of N-(4-hydroxyphenyl) retinamide (4HPR) as a chemopreventive agent in the presence of agents that potentiates its ability increase the expression of inducible nitric oxide synthase (iNOS), and NO production in cells.