N-((1-(6-methoxy-2-methylquinolin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)cyclopentanamine | 1247135-51-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-((1-(6-methoxy-2-methylquinolin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)cyclopentanamine
• 英文别名: N-[[1-(6-methoxy-2-methylquinolin-4-yl)triazol-4-yl]methyl]cyclopentanamine
• CAS: 1247135-51-8
• 化学式: C₁₉H₂₃N₅O
• 分子量: 337.425
• InChiKey: FZFUWVOSHDHPRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  64.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-叠氮基-6-甲氧基-2-甲基喹啉 、 N-propargylcyclopentylamine 在 copper(l) iodide 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 N-((1-(6-methoxy-2-methylquinolin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)cyclopentanamine
  参考文献：
  名称：

  Design, synthesis and antimicrobial activities of some new quinoline derivatives carrying 1,2,3-triazole moiety

  摘要：

  A new series of [1-(6-methoxy-2-methylquinolin-4-y1)-1H-1,2,3-triazol-4-yl] methanamine derivatives were synthesized starting from 4-methoxyaniline through multi-step reactions. The title compounds 5a-y were prepared by treating the azide intermediate 4 with propargyl bromide and different alkyl/heterocyclic amines in a sequential three component synthesis. All the new compounds were characterized by spectral and elemental analyses. The newly synthesized final compounds were evaluated for their in vitro antibacterial and antifungal activities against pathogenic strains. The preliminary screening results indicated that most of the compounds demonstrated moderate to very good antibacterial and antifungal activities, comparable to the first-line drugs. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.05.030

文献信息

• Design, synthesis and antimicrobial activities of some new quinoline derivatives carrying 1,2,3-triazole moiety
  作者：K.D. Thomas、Airody Vasudeva Adhikari、N. Suchetha Shetty

  DOI：10.1016/j.ejmech.2010.05.030

  日期：2010.9

  A new series of [1-(6-methoxy-2-methylquinolin-4-y1)-1H-1,2,3-triazol-4-yl] methanamine derivatives were synthesized starting from 4-methoxyaniline through multi-step reactions. The title compounds 5a-y were prepared by treating the azide intermediate 4 with propargyl bromide and different alkyl/heterocyclic amines in a sequential three component synthesis. All the new compounds were characterized by spectral and elemental analyses. The newly synthesized final compounds were evaluated for their in vitro antibacterial and antifungal activities against pathogenic strains. The preliminary screening results indicated that most of the compounds demonstrated moderate to very good antibacterial and antifungal activities, comparable to the first-line drugs. (C) 2010 Elsevier Masson SAS. All rights reserved.