N-acetyl-2,4-di-O-acetyl-5a-carba-3,6-di-O-(2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyl)-α-D-mannopyranosylamine | 142967-99-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetyl-2,4-di-O-acetyl-5a-carba-3,6-di-O-(2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyl)-α-D-mannopyranosylamine
• CAS: 142967-99-5
• 化学式: C₈₁H₇₃NO₂₅
• 分子量: 1460.46
• InChiKey: KMAYJCBKOHLMLI-QEOISGLASA-N

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 N-acetyl-2,4-di-O-acetyl-5a-carba-3,6-di-O-(2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyl)-α-D-mannopyranosylamine 在 吡啶 、 sodium methylate 作用下， 生成 5a-carba-3,6-di-O-(α-D-mannopyranosyl)-α-D-mannopyranosylamine undeca-N,O-acetate
  参考文献：
  名称：

  Synthesis of 2-O-(2-acetamido-2-deoxy-β-spD- glucopyranosyl)-5a-carba-α-spD-mannopyranose, and 5a-carba-2O- and 3,6-di-O-(α-d-mannopyranosyl)- α-spD-mannopyranoses

  摘要：

  Protected derivatives of the title carba-trisaccharide 1, and carba-disaccharides 4 and 6 have been synthesised by conventional glycosylation of the precursors 8, 9, or 22 of 5a-carba-alpha-D-mannopyranose with sugar halides. These are carba-sugar analogues of the oligosaccharide chains frequently occurring as structural units in biologically important glycoconjugates, and could be utilised as the building blocks for construction of higher carba-oligosaccharides of biological interest.

  DOI：

  10.1016/s0008-6215(00)90484-1
• 作为产物：
  描述：

  乙酸酐 、 1D-(1,2,4/3,6)-1,3-di-O-acetyl-6-azido-2,7-di-O-(2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyl)-4-(hydroxymethyl)cyclohexane-1,2,3-triol 在 镍 氢气 、 溶剂黄146 作用下， 以 乙醇 、 乙酸乙酯 为溶剂， 反应 48.0h， 以68%的产率得到N-acetyl-2,4-di-O-acetyl-5a-carba-3,6-di-O-(2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyl)-α-D-mannopyranosylamine
  参考文献：
  名称：

  Synthesis of 2-O-(2-acetamido-2-deoxy-β-spD- glucopyranosyl)-5a-carba-α-spD-mannopyranose, and 5a-carba-2O- and 3,6-di-O-(α-d-mannopyranosyl)- α-spD-mannopyranoses

  摘要：

  Protected derivatives of the title carba-trisaccharide 1, and carba-disaccharides 4 and 6 have been synthesised by conventional glycosylation of the precursors 8, 9, or 22 of 5a-carba-alpha-D-mannopyranose with sugar halides. These are carba-sugar analogues of the oligosaccharide chains frequently occurring as structural units in biologically important glycoconjugates, and could be utilised as the building blocks for construction of higher carba-oligosaccharides of biological interest.

  DOI：

  10.1016/s0008-6215(00)90484-1