(4aR,6R,7R,8S,8aR)-6-[(2R,3R,4S,5R,6S)-6-((1R,2R,3S,4R,5R)-3,4-Dimethoxy-6,8-dioxa-bicyclo[3.2.1]oct-2-yloxy)-4,5-dimethoxy-2-methoxymethyl-tetrahydro-pyran-3-yloxy]-7,8-dimethoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine | 214406-27-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4aR,6R,7R,8S,8aR)-6-[(2R,3R,4S,5R,6S)-6-((1R,2R,3S,4R,5R)-3,4-Dimethoxy-6,8-dioxa-bicyclo[3.2.1]oct-2-yloxy)-4,5-dimethoxy-2-methoxymethyl-tetrahydro-pyran-3-yloxy]-7,8-dimethoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine
• CAS: 214406-27-6
• 化学式: C₃₂H₄₈O₁₅
• 分子量: 672.724
• InChiKey: ZWOWMOHKLJMBTD-WJVQFFONSA-N

物化性质

• 沸点：
  713.685±60.00 °C(Press: 760.00 Torr)(predicted)
• 密度：
  1.298±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  (4aR,6R,7R,8S,8aR)-6-[(2R,3R,4S,5R,6S)-6-((1R,2R,3S,4R,5R)-3,4-Dimethoxy-6,8-dioxa-bicyclo[3.2.1]oct-2-yloxy)-4,5-dimethoxy-2-methoxymethyl-tetrahydro-pyran-3-yloxy]-7,8-dimethoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine 在 溶剂黄146 作用下， 反应 6.0h， 以86%的产率得到(2R,3R,4S,5R,6R)-6-[(2R,3R,4S,5R,6S)-6-((1R,2R,3S,4R,5R)-3,4-Dimethoxy-6,8-dioxa-bicyclo[3.2.1]oct-2-yloxy)-4,5-dimethoxy-2-methoxymethyl-tetrahydro-pyran-3-yloxy]-2-hydroxymethyl-4,5-dimethoxy-tetrahydro-pyran-3-ol
  参考文献：
  名称：

  Biological properties of synthetic glycoconjugate mimics of heparin comprising different molecular spacers

  摘要：

  The in vitro antithrombotic activity of synthetic glycoconjugates I and II, comprising a flexible polyethylene glycol type and a rigid polyglucose type spacer, respectively, are compared to heparin. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00382-5
• 作为产物：
  描述：

  (4aR,6R,7R,8R,8aS)-6-[(2R,3S,4R,5R,6S)-6-((1R,2R,3S,4R,5R)-3,4-Dimethoxy-6,8-dioxa-bicyclo[3.2.1]oct-2-yloxy)-4,5-dihydroxy-2-hydroxymethyl-tetrahydro-pyran-3-yloxy]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol 、 碘甲烷 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 (4aR,6R,7R,8S,8aR)-6-[(2R,3R,4S,5R,6S)-6-((1R,2R,3S,4R,5R)-3,4-Dimethoxy-6,8-dioxa-bicyclo[3.2.1]oct-2-yloxy)-4,5-dimethoxy-2-methoxymethyl-tetrahydro-pyran-3-yloxy]-7,8-dimethoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine
  参考文献：
  名称：

  Biological properties of synthetic glycoconjugate mimics of heparin comprising different molecular spacers

  摘要：

  The in vitro antithrombotic activity of synthetic glycoconjugates I and II, comprising a flexible polyethylene glycol type and a rigid polyglucose type spacer, respectively, are compared to heparin. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00382-5