[C-11]-D-mannitol | 214275-68-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [C-11]-D-mannitol
• 英文别名: D-<1-11C>mannitol；D-[1-11C]mannitol
• CAS: 214275-68-0
• 化学式: C₆H₁₄O₆
• 分子量: 181.163
• InChiKey: FBPFZTCFMRRESA-PTGVCDCYSA-N

反应信息

• 作为反应物：
  描述：

  [C-11]-D-mannitol 在 tris-buffer 、 β-烟酰胺腺嘌呤二核苷酸 、 D-mannitol dehydrogenase 作用下， 反应 0.12h， 生成 D-[1-11C]fructose
  参考文献：
  名称：

  Oegren, M.; Langstroem, B., Journal of labelled compounds and radiopharmaceuticals, 1997, vol. 40, p. 798 - 800

  摘要：

  DOI：
• 作为产物：
  描述：

  3,4:5,6-di-O-isopropylidene-D-<1-11C>-mannitol 在 盐酸 作用下， 以 水 为溶剂， 反应 0.08h， 生成 [C-11]-D-mannitol
  参考文献：
  名称：

  Synthesis of D-[1-11C]Mannitol and its Enzymatic Oxidation to D-[1/6-11C]Fructose.

  摘要：

  D-[1-C-11]Mannitol was synthesised from [C-11]methyl iodide using a Wittig reaction in combination with an asymmetric dihydroxylation (AD) followed by acid hydrolysis of the protecting groups. Unreacted triphenylphosphine was quenched by the addition of an oxidant, N-methylmorpholine N-oxide, prior to the AD. In the synthesis of D-[1-C-11]fructose, tris(hydroxymethyl) aminomethane buffer was used as the solvent and D-mannitol dehydrogenase and nicotinamide adenine dinucleotide were added after pH adjustment. The enzyme was denatured and the solution was filtered prior to injection into a semi-preparative HPLC-system. Starting from 9.8 GBq [C-11]methyl iodide, the yield was 0.37 GBq D-[1-11C]mannitol and 0.12 GBq D-[1-C-11]fructose in 60 and 70 min, respectively. The radiochemical decay-corrected yield was 29% in the synthesis of D-[1-11C]mannitol and 15% for the synthesis of D-[1-C-11]fructose. The radiochemical purities exceeded 97% for the two C-11-labelled monosaccharides. A mixed C-11/C-13-experiment was performed in order to confirm the labelling positions with C-13 nuclear magnetic resonance spectroscopy.

  DOI：

  10.3891/acta.chem.scand.52-1137

文献信息

• Dence, C. S.; Powers, W. J.; Welch, M. J., Journal of labelled compounds and radiopharmaceuticals, 2001, vol. 44, p. S137 - S139
  作者：Dence, C. S.、Powers, W. J.、Welch, M. J.

  DOI：——

  日期：——