| 247078-21-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 247078-21-3
• 化学式: C₅₉H₇₀N₆O₃₀S
• 分子量: 1375.29
• InChiKey: QMYNYRCNJKXUAE-RVXSFWKESA-N

反应信息

• 作为反应物：
  描述：

  在 palladium on activated charcoal sodium hydroxide 、 氢气 、 三氧化硫吡啶 作用下， 以 水 、 叔丁醇 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  A synthetic heparan sulfate pentasaccharide, exclusively containing l -iduronic acid, displays higher affinity for FGF-2 than its d -glucuronic acid-containing isomers

  摘要：

  It has been suggested that the FGF-2 binding site on heparan sulfate chains is a trisulfated pentasaccharide containing three hexuronic acid units. The configuration at C-5 of two of them being undetermined, we have synthesized the four possible pentasaccharides, and have evaluated their FGF-2 binding affinity through in vitro biological assays. The pentasaccharide containing L-iduronic acid as the sole hexuronic acid showed higher affinity for FGF-2 than the other pentasaccharides, where one hexuronic acid unit at least is D-glucuronic acid. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00106-6
• 作为产物：
  描述：

  在 lithium hydroxide 、 双氧水 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 20.0h， 以100%的产率得到
  参考文献：
  名称：

  A synthetic heparan sulfate pentasaccharide, exclusively containing l -iduronic acid, displays higher affinity for FGF-2 than its d -glucuronic acid-containing isomers

  摘要：

  It has been suggested that the FGF-2 binding site on heparan sulfate chains is a trisulfated pentasaccharide containing three hexuronic acid units. The configuration at C-5 of two of them being undetermined, we have synthesized the four possible pentasaccharides, and have evaluated their FGF-2 binding affinity through in vitro biological assays. The pentasaccharide containing L-iduronic acid as the sole hexuronic acid showed higher affinity for FGF-2 than the other pentasaccharides, where one hexuronic acid unit at least is D-glucuronic acid. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00106-6