(R)-(+)-1,2-dicyclohexylethanol | 1162674-57-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-(+)-1,2-dicyclohexylethanol
• CAS: 1162674-57-8
• 化学式: C₁₄H₂₆O
• 分子量: 210.36
• InChiKey: KLKJCYNCADGMQJ-CQSZACIVSA-N

物化性质

• 熔点：
  81-82 °C(Solvent: Hexane)
• 沸点：
  292.2±8.0 °C(predicted)
• 密度：
  0.947±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  (R)-(+)-1,2-dicyclohexylethanol 在 迭氮酸 、 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 甲苯 为溶剂， 反应 1.25h， 以81%的产率得到(S)-(-)-1-azido-1,2-dicyclohexylethane
  参考文献：
  名称：

  NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds

  摘要：

  We resolved 1,2-diphenylethylamine (DPEA) into its (S)- and (R)- enantiomer and used them as precursors for synthesis of (S)- and (R)-1-(1,2-diphenylethyl)piperidine,flexible homeomorphs of the NMDA channel blocker MK-801. We also describe the synthesis of the dicyclohexyl analogues of DPEA. These and related compounds were tested as inhibitors of [(3)H]MK-801 binding to rat brain membranes. Stereospecificity ranged between factors of 0.5 and 50. Some blockers exhibited stereospecific sensitivity to the modulator spermine. Our results may help to elucidate in more detail the NMDA channel pharmacophore. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.03.025
• 作为产物：
  描述：

  (R)-(+)-1,2-dicyclohexylethyl 4-nitrobenzoate 在 甲醇 、 sodium methylate 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以87%的产率得到(R)-(+)-1,2-dicyclohexylethanol
  参考文献：
  名称：

  NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds

  摘要：

  We resolved 1,2-diphenylethylamine (DPEA) into its (S)- and (R)- enantiomer and used them as precursors for synthesis of (S)- and (R)-1-(1,2-diphenylethyl)piperidine,flexible homeomorphs of the NMDA channel blocker MK-801. We also describe the synthesis of the dicyclohexyl analogues of DPEA. These and related compounds were tested as inhibitors of [(3)H]MK-801 binding to rat brain membranes. Stereospecificity ranged between factors of 0.5 and 50. Some blockers exhibited stereospecific sensitivity to the modulator spermine. Our results may help to elucidate in more detail the NMDA channel pharmacophore. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.03.025