| 1101835-04-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1101835-04-4
• 化学式: C₂₆H₄₀O₁₀Si
• 分子量: 540.683
• InChiKey: DPERNHHIYSOIAH-RYWAYVEBSA-N

反应信息

• 作为反应物：
  描述：

  在 Jones reagent 作用下， 以 丙酮 为溶剂， 以19%的产率得到(2S,3R,4R,5S,6S)-3,4,5-triacetoxy-6-(3,6-dioxocyclohexa-1,4-dienyl)-tetrahydro-2H-pyran-2-carboxylic acid
  参考文献：
  名称：

  β-C-Glycosiduronic acids and β-C-glycosyl compounds: New PTP1B inhibitors

  摘要：

  beta-C-Glycosiduronic acid quinones and beta-C-glycosyl compounds have been synthesized as sugar-based PTP1B inhibitors. Benzoyl protected quinone derivatives (14 and 35) as well as aryl beta-C-glycosyl compounds (18, 22, 23 and 34) showed IC50 values of 0.77-5.27 mu M against PTP1B, with compounds 18 and 23 bearing an acidic function being the most potent. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.091
• 作为产物：
  描述：

  、 乙酸酐 生成
  参考文献：
  名称：

  β-C-Glycosiduronic acids and β-C-glycosyl compounds: New PTP1B inhibitors

  摘要：

  beta-C-Glycosiduronic acid quinones and beta-C-glycosyl compounds have been synthesized as sugar-based PTP1B inhibitors. Benzoyl protected quinone derivatives (14 and 35) as well as aryl beta-C-glycosyl compounds (18, 22, 23 and 34) showed IC50 values of 0.77-5.27 mu M against PTP1B, with compounds 18 and 23 bearing an acidic function being the most potent. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.091