1-(4-chloro-2,6-dimethylquinolin-3-yl)propan-2-one | 957220-43-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(4-chloro-2,6-dimethylquinolin-3-yl)propan-2-one
• CAS: 957220-43-8
• 化学式: C₁₄H₁₄ClNO
• 分子量: 247.724
• InChiKey: PYOQVTDJMIDZOV-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  1-(4-chloro-2,6-dimethylquinolin-3-yl)propan-2-one 在 sodium hydroxide 作用下， 以 丙酮 为溶剂， 反应 1.5h， 生成 1-(2,6-dimethyl-4-thioxo-1,4-dihydroquinolin-3-yl)propan-2-one
  参考文献：
  名称：

  Synthesis of substituted 2,4-dimethylthieno[3,2-c]quinolines

  摘要：

  A procedure was developed for the synthesis of substituted 2,4-dimethylthieno[3,2-c]quinolines via intramolecular cyclization and subsequent arornatization of 3-(2-chloroprop-2-en-1-yl)- and 3-(2-oxopropyl)-2methylquinoline-4-thiols. The latter were obtained by alkaline hydrolysis of the corresponding thiuroniurn salts which were prepared in turn by reactions of 4-chloro-3-(2-chloroprop-2-en-1-yi)- and 4-chloro-3-(2-oxopropyl)-2-methylquinolines with thiourea.

  DOI：

  10.1134/s1070428007030165
• 作为产物：
  描述：

  4-chloro-3-(2-chloroprop-2-en-1-yl)-2,6-dimethylquinoline 在 硫酸 作用下， 以97%的产率得到1-(4-chloro-2,6-dimethylquinolin-3-yl)propan-2-one
  参考文献：
  名称：

  Synthesis of substituted 2,4-dimethylthieno[3,2-c]quinolines

  摘要：

  A procedure was developed for the synthesis of substituted 2,4-dimethylthieno[3,2-c]quinolines via intramolecular cyclization and subsequent arornatization of 3-(2-chloroprop-2-en-1-yl)- and 3-(2-oxopropyl)-2methylquinoline-4-thiols. The latter were obtained by alkaline hydrolysis of the corresponding thiuroniurn salts which were prepared in turn by reactions of 4-chloro-3-(2-chloroprop-2-en-1-yi)- and 4-chloro-3-(2-oxopropyl)-2-methylquinolines with thiourea.

  DOI：

  10.1134/s1070428007030165