| 958310-21-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 958310-21-9
• 化学式: C₄₁H₆₄N₂O₂₂Si
• 分子量: 965.045
• InChiKey: IZKQKRPASROINV-JLKYCOBYSA-N

反应信息

• 作为反应物：
  描述：

  在 sodium methylate 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 以94%的产率得到D-Fuc(a1-3)[GalNAc(b1-4)]GlcNAc(b)-O-EtTMS
  参考文献：
  名称：

  Synthesis and biological activities of glycosphingolipid analogues from marine sponge Aplysinella rhax

  摘要：

  A novel glycosphingolipid, P-D-GalNAcp(l -> 4)[alpha-D- Fucp(1 -> 3)]-beta-D-GIcNAcp(1 -> 3)Cer(1), isolated from the marine sponge Aplysinella rhax, has a unique structure, with D-fucose and N-acetyl-D-galactosamine attached to a reducing-end N-acetyl-D-glucosamine through an alpha 1 -> 3 and beta 1 -> 4 linkage, respectively. We synthesized glycolipid analogues carrying a 2-branched fatty alkyl residue or a 2-trimethylsilyl ethyl residue in place of ceramide (2 and 3), non-natural type trisaccharide analogue containing an L-fucose residue (4), and other analogues (5 and 6). Among these prepared compounds, 2 showed the most potent nitric oxide (NO) production inhibitory activity against LPS-activated J774.1 cells. In addition, their structure-activity relationships were established. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.07.108
• 作为产物：
  描述：

  、 乙酸酐 在 吡啶 作用下， 生成
  参考文献：
  名称：

  Synthesis and biological activities of glycosphingolipid analogues from marine sponge Aplysinella rhax

  摘要：

  A novel glycosphingolipid, P-D-GalNAcp(l -> 4)[alpha-D- Fucp(1 -> 3)]-beta-D-GIcNAcp(1 -> 3)Cer(1), isolated from the marine sponge Aplysinella rhax, has a unique structure, with D-fucose and N-acetyl-D-galactosamine attached to a reducing-end N-acetyl-D-glucosamine through an alpha 1 -> 3 and beta 1 -> 4 linkage, respectively. We synthesized glycolipid analogues carrying a 2-branched fatty alkyl residue or a 2-trimethylsilyl ethyl residue in place of ceramide (2 and 3), non-natural type trisaccharide analogue containing an L-fucose residue (4), and other analogues (5 and 6). Among these prepared compounds, 2 showed the most potent nitric oxide (NO) production inhibitory activity against LPS-activated J774.1 cells. In addition, their structure-activity relationships were established. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.07.108