| 1297292-50-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1297292-50-2
• 化学式: C₃₈H₅₅N₁₁O₁₅
• 分子量: 905.919
• InChiKey: ACGAYXHIRFWCQI-OXEZHCTRSA-N

反应信息

• 作为产物：
  描述：

  BOC-甘氨酸 、 Fmoc-L-丙氨酸 、 (2R)-2-[2-(9H-fluoren-9-ylmethoxy)-2-oxoethyl]-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid 、 FMOC-O-叔丁基-L-丝氨酸 、 Fmoc-L-天冬氨酸 beta-叔丁酯 、 Fmoc-O-叔丁基-L-谷氨酸 、 N-叔丁氧羰基-L-色氨酸 在 甲醇 、 N,N-二异丙基乙胺 、 4-甲基哌啶 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Antioxidant and detoxifying activities of analogues of the delta sleep inducing peptide

  摘要：

  Sixteen peptides differing in structure from the delta sleep inducing peptide (DSIP) by one to two substitutions of amino acid residues have been synthesized to study the possibility of their application in oncology. The antioxidant properties of the peptides in vitro and their detoxifying activity in vivo have been examined on a model of toxicosis caused by cisplatin, a cytostatic drug widely used in the therapy of tumor diseases. It has been shown that almost all DSIP analogues examined exhibit a direct antioxidant activity, with the activity of the ID-6 analogue being higher than that of DSIP and comparable with that of vitamin C and beta-carotene. This analogue shows the most pronounced detoxifying activity toward the action of cisplatin, which manifests itself as a decrease in the death of animals from acute toxicity to 17% compared to 50-67% in the control and the restoration of some biochemical parameters of blood, in particular, a decrease in the activity of the enzymes, aspartate and alanine aminotransferases, and the concentration of the end products of nitrogen exchange: creatinine and urea. Thus, the peptides of the DSIP family may appear promising agents for decreasing the toxic effects of cytostatics used in oncology.

  DOI：

  10.1134/s1068162014010087