2^A-O-(6-hydroxyhexyl)-per-O-methylated α-CD | 1400566-06-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2^A-O-(6-hydroxyhexyl)-per-O-methylated α-CD
• CAS: 1400566-06-4
• 化学式: C₅₉H₁₀₆O₃₁
• 分子量: 1311.47
• InChiKey: HJLIXAWWRVINFC-ZTWVEVBXSA-N

反应信息

• 作为反应物：
  描述：

  2^A-O-(6-hydroxyhexyl)-per-O-methylated α-CD 、 乙酸酐 在 吡啶 作用下， 反应 18.0h， 以90%的产率得到2^A-O-(6-acetyloxyhexyl)-per-O-methylated α-CD
  参考文献：
  名称：

  Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors

  摘要：

  An alpha-cyclodextrin-[60] fullerene conjugate with a flexible linker at the secondary face of alpha-cyclodextrin has been prepared, which displays significant water solubility and, more importantly, acts as a new class of HCV entry inhibitor with IC50 at 0.17 mu M level. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.07.029
• 作为产物：
  描述：

  2^A-O-(6-benzyloxyhexyl)-per-O-methylated α-CD 在 10% Pd/C 、 氢气 作用下， 以 甲醇 为溶剂， 反应 16.0h， 以95%的产率得到2^A-O-(6-hydroxyhexyl)-per-O-methylated α-CD
  参考文献：
  名称：

  Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors

  摘要：

  An alpha-cyclodextrin-[60] fullerene conjugate with a flexible linker at the secondary face of alpha-cyclodextrin has been prepared, which displays significant water solubility and, more importantly, acts as a new class of HCV entry inhibitor with IC50 at 0.17 mu M level. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.07.029